NAPRT1

Nicotinate phosphoribosyltransferase 1

559 amino acids

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.

Belongs to the NAPRTase family.

62.421 kDa

MEKKENGLDGKQSGRVINGPTNPMVTPLLNDLYQFTMAYAYWKAGKQSERSVFDLYFRKNPFGGEYTIFAGLEECIKFLANFNLTDEEIDFVRDSLPGCEEAFCDYLRGLDCSDIEVYAISEGSVVFPKVPLLRIEGPVAVVQLLETPFLNLINYASLVATNAARHRFVAGKSKLLLEFGARRAQGPDGAISASKYCYLGGFDATSNVAAGKLFGIPLRGTHSHAFVSSFMSLDEIVDKVLRSSDGKSTCKDFICLVQTCLTKIQNSSSLQGIFSETNQSELAAFISYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNELGYKAVGIRLDSGDLAYLSTEVRKFFCAIERDLKVPDFGKMIVTASNDLNEETVDALNKQGHEVDAFGIGTNLVTCYAQAALGCVFKLVEINNQPRIKLSEDVTKVSIPCKKRTYRLFGKEGYPLVDIMTGENEPPPKVGERLLCRHPFNESKRAYVVPQRVEELLKCYWRGNADEAREELEPLKELRNRCIKQLENMRPDHMRRLNPTPYKVSVSAKLYDFIHFLWLNEAPVGELH