Protein
Membrane-embedded CAAX protease MroQ
Organism
Staphylococcus aureus (strain USA300)
Function
Participates in the regulation of the Agr quorum sensing activity and plays thereby an important role in virulence (PubMed:30833335, PubMed:30833334). Mechanistically, elicits a protease dependent control of Agr activity without playing a role in the processing of the pheromone-precursor AgrD (PubMed:30833335).
Similarity
Belongs to the peptidase U48 family.
Sequence
MTRLWASLLTVIIYILSQFLPLLIVKKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVLTQIYGGQQVSPNTEKLIIIARKIPIFIFFVSIIGPLLEEYVFRKVIFGELFNAIKGNRIVAFIIATTVSSLIFALAHNDFKFIPVYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP