Protein
S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Function
Involved in the archaeal biosynthesis of heme. Catalyzes the methylation of carbons 2 and 7 of uroporphyrinogen-III (UROGEN) to yield precorrin-2. It does not catalyze the overmethylation of precorrin-2 to trimethylpyrrocorphin.
Similarity
Belongs to the precorrin methyltransferase family.
Sequence
MSGNYGKVYLVGSGPGDPELLTLKARRLIDSAEVIVYDQLPGKAILDSMPASAEKINVGKYAGSHTMTQAEINEVLVQKAKEGKMVVRLKGGDPYVFGRGGEEAEVLVAEEIEFEVVPGITSAIAVPAYAGIPVTHRESTSMVTFITGHEDPTKEESGLDWETLAKFGGTIVILMGVKMLGRNAEELMKHGKAPDTPVAVIERGTRADQRVTVGTLANIASLAEERKVKAPAITVVGDVVHLHDILGEQRTGVDF