Organism
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)
Function
Interacts with the host phosphatase PP1 catalytic subunit (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and therefore restores the host translation that has been shut-down by the host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.
Similarity
Belongs to the asfivirus DP71L family.
Sequence
MSRRNKRSRRRRKKPLNTIQPGPSKPSAQDEPIKSVSHHSSKIGTNPMLAFILGGNEDLSDDSDWDEDFSLENTLMPLNEVSLKGKHDSKHFNKGFDNNTALHEVNTKWEAFYSSVKIRQRDVKVYFATDDILIKVREADDIDRKGPWEQAAVDRLRFQRRIADTEKILSAVLLRKKLNPMEHE