Protein
Inhibitor of apoptosis protein
Organism
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)
Function
Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation. Induces also the activation of host NF-kappaB.
Similarity
Belongs to the asfivirus IAP family.
Sequence
MYPKINTIDTYISLRLFEVKPKYVGYSSVDARNKSFAIHDIKNYEKFSNAGLFYTSPTEITCYCCGMKFCNWIYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYFTNEVSVKHKNRVYTHKRLEDMGFSKSFMRFILANAFMPPYRKYIHKIILNERYFTFKFVAYLLSFHKVNLDNQITYCMTCGIEQINKDENFCNACKPLNYKHYKILNFSVKL