Myo1g

Unconventional myosin-Ig

1024 amino acids

Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration (PubMed:25083865). Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication (PubMed:25083865). Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes (PubMed:24310084). Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis (PubMed:23038771).

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

117.227 kDa

MLAVGRMEDEEGPEYGKPDFVLLDQLTMEDFMKNLELRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQGLHLERNPAVYNFTRQGAGLNMGVHNALDSDEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNIEFVETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHTVAEASYARDACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVELVEQPHRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSVDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLGSDRDAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWHCRRLRAIYTIMRWFRRHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCRVLFSRWRARQLVKNIPPSDMIQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHLFAEQLKALREKDGFGSVLFSSHVRKVNRFRKSRDRALLLTDRYLYKLEPGRQYRVMRAVPLEAVTGLSVTSGRDQLVVLHAQGYDDLVVCLHRSQPPLDNRIGELVGMLAAHCQGEGRTLEVRVSDCIPLSQRGARRLISVEPRPEQPEPDFQSSRSTFTLLWPSH

MYO1G

Unconventional myosin-Ig

1018 amino acids

Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

116.442 kDa

MEDEEGPEYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLARTVASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERPHRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNPTASSLFAQRLKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPDRQYRVMRAVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAHCQGEGRTLEVRVSDCIPLSHRGVRRLISVEPRPEQPEPDFRCARGSFTLLWPSR

MYO1G

Unconventional myosin-Ig

1007 amino acids

Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication.

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

114.97 kDa

MTELEGPEFGKADFVLLDEVTMEHFMENLRLRFSKGRIYTYIGEVVVAMNPYQPLELYGPSVVEQYRGRELYERPPHLFALADAAYKAMKRRAKDTCIVISGESGAGKTEASKYIMQYIAAITNPTQRAEVERVKNGLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPTGGHIYNYLLEKSRVLQQQPGERNFHSFYQLLLGAPDALLASLHLQRDPTAYCYTQQGTQGSAGGDDARGYRAVEEAMAVIGFTPEEVGAVQRILAAILHLGNVQFVAEGEVAALEAVEQLAVLAQLTGTTPEQLRQALLARTVATGGGELIEKGHSPTEAAYGRDACAKAIYERLFGWIVGRINASITARGYDVRQHGKSTVIGVLDIYGFEIFDTNSFEQFCINYCNEKLQQLFIELILRQEQAEYQREGITWQNIEYFSNEPIVELVEQPHRGILALLDEACLAVGTVTDALFLANMDARLGHHPHYSSRKLCPTDKTMEFDRDFRIKHYAGDVTYSVEGFLDKNKDTLFQDFKRLLYNSMDPVLRAMWPDGEQSITEVTKRPLTAATLFKNSIVALVENLASKEPYYVRCIKPNDQKSPVLFDEERCRHQVAYLGLLENVRVLRAGFAYRQPYDRFLQRYKMTCEYTWPNHLMATDREATQTLLEQHGFQDDVAYGHTKVFIRTPRTLFCLEQERAQLIPIIVLLLQKAWRGALARRWCRYLRAAYAIMGYYKRHKVKAYLLELIRRFQGVRSMPDFGKSLAWPEPPAVLSRFQENSQQLFRRWRARQIVKNIPPSDMAQIRAKVAAMGALHGLRKDWGCQRGWVRDYLSSASENPGLALPFAHRVQALRDKVHFGAVLFSSHVRKINRFNKSRDRAILITDQHLYKLEPRKQYRVMRELPLSMVTGLSVTSCRAQLVVFHTQNHDDLAVCLHKTQPRGDERVGELVGVLLEHCRTTKRELQVHVSDRIQLSLRGRKRLLTVETQPDVAAPDFRKSRDGFVLYWPGS