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MTS1

Gene
MTS1
Protein
Sphingolipid C9-methyltransferase
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
513 amino acids
Function
Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals, and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses. Not necessary for vegetative growth at low temperatures, but plays a role in hyphal formation on solid medium.
Similarity
Belongs to the CFA/CMAS family.
Mass
58.777 kDa
Sequence
MLDDVAFIKTPAAKKQPPASNECGVWTTDSPAIHNAPLPADGPGSTSFSNTILFSILALVPGYITYKLGLGFKTWVFFFLILAIPILMAYWSIMSTFSPRINEKVKYPNRPISYYLEFHTPELKAKYETSNGGKGSKIPIETFQELYFDGKVSFKGDCLDVLEYKHDWASFRFTLGLFRFFLLGMIPEVIFHSQSQDEEQVRDHYDRGDDFYTWFLGPRMIYTSGVISDITREETLEELQDNKLTVMADKIDLKKGDHVLDIGCGWGTWTTFASSKYGANVTGITLGRNQTKWGNTLLKEYGIPSDQSRIVCCDYRDAPKSSKPSGKYDKITSVEMAEHVGIRRLTAYLEQCRDALEDDGLLFLQYSGLRKNWQYEDLEWGLFMNKYIFPGADASTPLSFFASCMESVGFEIVSVDNIGVHYSATLWRWYRNWIGNKDKVVNKYGVKWYRIWEFFLGSSVVASRNGTATCYQFICRKNINSYRRIDYVPQQKGLQGPVQEGTKWAKEFTNFYD