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MTOPVIB

Gene
MTOPVIB
Protein
Type 2 DNA topoisomerase 6 subunit B-like
Organism
Arabidopsis thaliana
Length
473 amino acids
Function
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11 (SPO11-1 and SPO11-2), mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
Similarity
Belongs to the TOP6B-like family.
Mass
53.344 kDa
Sequence
MENNAPVPKLLLQLISSAFQRCRLAEDLCRLSVLLDQSTERDPPITCISIADTGIGCNLEEFQNLRCPREFNGAKIWDGLLSVKTTCFTDDEVYYYHINLDEYIANKRLKRQPSQAKNGAKFSGTEVSLSVFGSMDVLVAPIIGFFQKIIVLQILNVTLDLMVKQGTSPGNQTQYVFAVNADKTPCFTASNLERLKSGLEDYVLRHANCLDTMCDYCFSDREHLKVGSGTVCQEDKHKRVGGTMEVVIVISDLLESTQHCSRSCNGKTEVLYFDNFLPSPVPHLALSALKKIDWKKYGLILANVNDQDGHVFLEWDNFPSYVQIQIALHWYHNQYPTRQKNGPGISLLKKGIKNALDNLKAKHEGFLLSSHSRKICSYVPDLARSIAGLIFSSTDLDFQGDCLSVLGFQTQEVERDTVENYIQRKIVTVIGMNERKPQKDQEAAPFLFFDGESETSFFEDEEVEGEYYSSSLE