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MTM1

Gene
MTM1
Protein
Phosphatidylinositol-3-phosphatase myotubularin-1
Organism
Arabidopsis thaliana
Length
840 amino acids
Function
Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus. Required for recovery after water deprivation, via the accumulation of PtdIns5P upon dehydration; high PtdIns5P levels mediate ATX1 cytoplasmic localization, thus down-regulating the expression of ATX1-dependent genes. Confers sensitivity to soil-water-deficit stress.
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
93.378 kDa
Sequence
MTPPRPPSGRVRSLRDYSSESEKMDGTGSWDTLEWTKLDSTSGSGSFSNLSCLLESERVIVEGYGVVLINTDEAGTLLVTNFRILFLSEGTRKVIPLGTIPLATIEKFNKMVLKVQSSPRQSDKIPPRRLLQVTGKDMRIIVYGFRPRTKQRRNVFDALLKCTKPERVWDLYTFACGPSKFGNANPKERLLNEYFRLLGKSSIRASMDMIEDGAFTLSNELWRISDLNSNYNLCQTYPFAFMIPKSISDAELLQACSFRARCRLPVITWCQPGSGAVIARSSQPLVGLMMNMRSNLDEKLVAAFCSQLPGAKGERRKLYIADARPRKNALANGAMGGGSESSSNYFQSEIVFFGIDNIHAMRESFSRVRDYLDMHGTTSSDGRSSFLRHGGWTWGGGNLSSMSASVSLLGDSGWLIHIQSVLAGAAWIAARVAMESASVLVHCSDGWDRTTQLVSLACLLLDPYYRTFAGFQALVEKDWLAFGHPFSDRVGMPNISGSGNFDFPRQSSSAGSFPSSPVRQSSGSAASQSSSSSHGHNNYSPIFMQWIDSVSQLMRMYPCAFEFSPTFLVDFMDCLLSCRFGNFLCNSEKEREQCGIADACGCLWAYLTDLRSFSATSHVHCNPFYDPLKYDGPLLPPAASLAPTLWPQFHLRWACPEEAKAADIGVQCRAMTVKYSEMQKEKEAAERRVDEISFAMESLSAELLRERHLSWVARESANRATKEYAALTRAVQSLGCKINFTTSDVEDDPRSSLENNPRRRNRHGNNSDVSVSISLMPEENTSGNPKGRVCEALCPLRTREGVCRWPEVGCAHVGSQFVGLKANFDAFDRLAIYDSYFQPK

Gene
MTM1
Protein
Myotubularin
Organism
Bos taurus
Length
603 amino acids
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
70.02 kDa
Sequence
MASAPTSKYNSHSLENESIKRTSRDGVNRDVGETLPRLPGEIRITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPIFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYKLCDTYPALLVVPYRASDEDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKEDERYLDVIRETNRQVNKLTIYDARPNVNAVANKATGGGYESDDVYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADRVSSGKSSVVVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNERFLITILDHLYSCRFGTFLYNCESAREKQKVTERTVSLWSLINSNKDKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLDELQLANSAKLSDPSASPSSPSQMMPHVQTHF

Gene
MTM1
Protein
Myotubularin
Organism
Homo sapiens
Length
603 amino acids
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
69.932 kDa
Sequence
MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQTHF

Gene
Mtm1
Protein
Myotubularin
Organism
Mus musculus
Length
603 amino acids
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology (By similarity). Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:12391329). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
69.559 kDa
Sequence
MASASASKYNSHSLENESIKKVSQDGVSQDVSETVPRLPGELLITEKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILVKHAFPLAHNLPLFAFVNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRISFINKCYELCETYPALLVVPYRTSDDDLRRIATFRSRNRLPVLSWIHPENKMVIMRCSQPLVGMSGKRNKDDEKYLDVIRETNKQTSKLMIYDARPSVNAVANKATGGGYESDDAYQNSELSFLDIHNIHVMRESLKKVKDIVYPNIEESHWLSSLESTHWLEHIKLVLTGAIQVADQVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRTIEGFEILVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNEGFLITVLDHLYSCRFGTFLFNCDSARERQKLTERTVSLWSLINSNKDKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRVKQQQPNPVEQRYMELLALRDDYIKRLEELQLANSAKLADAPASTSSSSQMVPHVQTHF

Gene
MTM1
Protein
Myotubularin
Organism
Pongo abelii
Length
603 amino acids
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
69.9 kDa
Sequence
MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPAPLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQTHF

Gene
Mtm1
Protein
Myotubularin
Organism
Rattus norvegicus
Length
602 amino acids
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
69.352 kDa
Sequence
MASSSASDCDAHPVERESMRKVSQDGVRQDMSKSGPRLPGESAITDKEVIYICPFSGPVKGRLYITNYRLYLRSLETDLAPILDVPLGVISRIEKMGGVTSRGENSYGLDITCKDLRNLRFALKQEGHSRRDIFDVLTRHAFPLAYNLPLFAFVNEEKFKVDGWAIYNPVEEYRRQGLPDRHWRISFVNQRYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENRAAIMRCSQPLVGVGGKRSRDDERYLDIIRETNKQTSKLTIYDARPGVNAVANKATGGGYEGEDAYPHAELSFLDIHNIHVMRESLRRVRDIVYPHVEEAHWLSSLESTHWLEHIKLLLTGAIRVADKVASGLSSVLVHCSDGWDRTAQLTTLAMLMLDGFYRSIEGFEILVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVWQMTKQFPTAFEFNECFLVAILDHLYSCRFGTFLLNCEAARERQRLAERTVSVWSLINSNKDEFTNPFYARESNRVIYPVTSVRHLELWVNYYIRWNPRIRQQPHPMEQRYNELLALRDDYIKKLEELQLATPTKLTDSSTPPSGSAQIAPRMQTHF

Gene
mtm1
Protein
Myotubularin
Organism
Xenopus laevis
Length
602 amino acids
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
69.73 kDa
Sequence
MATSSTPKYNSNSLENSVRRSPGDGINHEQNDEISRLPGETLITDKEVIYMCPFYGPVKGRIYVTNYKLYFKGEEMEPLITFAVPLGVIARIEKMGGASSRGENSYGLDITCKDMRNLRFALKQEVHSRKQIFEDLTKYAFPLSHGLLFFAFQNEEKFPENGWAVYDAMTEFRRQGLPNDQWRITFINRNYELCDTYPPLLVVPYSASEEDLKRVAAFRSRNRIPVLSWLHPENQSAIMRCSQPLVGMSGKRNKDDERYLDIIRETNGQTSKLTIYDARPNVNAVANKATGGGYENEDAYPNAELVFLDIHNIHVMRESLKKLKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVASGKSSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIVGFEVLVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNEHFLITILDHLYSCRFGTFLYNCETIRDKEKVREKTPSLWSLISSEKSKYTNPFYTKELNRVLYPVASMRHLELWVNYYIRWNPRIRQQQPNPVEQRYMELLALRDDYVRRLEELQISNSPKINRSTTSPSSPSQMMPQVQTPF

Gene
mtm1
Protein
Myotubularin
Organism
Xenopus tropicalis
Length
602 amino acids
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
69.459 kDa
Sequence
MASNSTPKYNSNSLENSLRRSPGDGMNHEQNDEIPCLPGEALITDKDVIYMCPFYGPVKGRIHVTNYKLYFKGEEMEPLISFSVPLGVIARIEKMGGASSRGENSYGLDITCKDMRNLRFALKQEVHSRKQIFEDLTKYAFPLSHGLLLFAFQNEEKFPENGWAVYDAMTEFRRQGLPNGQWRITFINKNYELCDTYPPLLVVPYSASEEDLKKVAAFRSRNRIPVLSWLHPENQSAIMRCSQPLVGMSGKRNKDDERYLDIIRDTNGQTSKLTIYDARPNVNAVANKATGGGYESEDAYPNAELVFLDIHNIHVMRESLKKLKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVASGKSSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIVGFEVLVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNEHFLITVLDHLYSCRFGTFLYNCENIRDKEKVREKTQSLWSLISSEKSKYTNPFYTKELNRVLYPVASMRHLELWVNYYIRWNPRIRQQQPNPVEQRYMELLALRDDYVRRLEELQITNSPKMNSSTTSPSSPSQIMPQVHTPF

Gene
MTM1
Protein
Mitochondrial carrier protein MTM1
Organism
Arabidopsis thaliana
Length
413 amino acids
Function
Involved in the mitochondrial activation of MSD1 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner.
Similarity
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Mass
44.534 kDa
Sequence
MVEAERAENSWIASETSPSSSPVVIESSDFSITDGMRDVSGFGIASRPQLDKGLSENNIGFTERVFSAAGAAVLSAVTLNPLDVVKTRLQAQAAGMSYSHPLSNSIGRMAFFGPNMMFADLRCSPSCARAGVEGTVSICPPDCFQYKGTFDVFTKIIRQEGLGRLWRGTNAGLALAVPMVGIYLPFYDMFRNRLEELSREKAPAMTFCVPTVAGSLARSLACTVCYPIDLARTRMQAFKEAKAGVKPPGVFKTLVGVFSEVRTANNLESSLHNYRGLWRGLGAQLARDVPFSAICWSTLEPIKKRLLGVAGNDTNLVGVFGATFSAGFIAGSIAAAATCPLDVARTRRQIEKDPGRALMMTTRQTLIEVWRDGGMRGLFMGMGPRVARAGPSVGIVVSFYEVVKYVLHRHASS

Gene
MTM1
Protein
Mitochondrial carrier protein MTM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
366 amino acids
Function
Involved in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner. Responds to calorie restriction (CR) strength.
Similarity
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Mass
40.763 kDa
Sequence
MSDRNTSNSLTLKERMLSAGAGSVLTSLILTPMDVVRIRLQQQQMIPDCSCDGAAEVPNAVSSGSKMKTFTNVGGQNLNNAKIFWESACFQELHCKNSSLKFNGTLEAFTKIASVEGITSLWRGISLTLLMAIPANMVYFSGYEYIRDVSPIASTYPTLNPLFCGAIARVFAATSIAPLELVKTKLQSIPRSSKSTKTWMMVKDLLNETRQEMKMVGPSRALFKGLEITLWRDVPFSAIYWSSYELCKERLWLDSTRFASKDANWVHFINSFASGCISGMIAAICTHPFDVGKTRWQISMMNNSDPKGGNRSRNMFKFLETIWRTEGLAALYTGLAARVIKIRPSCAIMISSYEISKKVFGNKLHQ