About Products Protein Database Contact

MT-RNR1

Gene
MT-RNR1
Protein
Mitochondrial-derived peptide MOTS-c
Organism
Homo sapiens
Length
16 amino acids
Function
Regulates insulin sensitivity and metabolic homeostasis. Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity.
Mass
2.175 kDa
Sequence
MRWQEMGYIFYPRKLR