MSH1

DNA mismatch repair protein MSH1, mitochondrial

1118 amino acids

DNA mismatch repair protein specifically involved in maintenance of mitochondrial genome configuration by controlling specific rearranged portion. Functions by suppressing asymmetric recombination at some repeat pairs.

Belongs to the DNA mismatch repair MutS family.

123.92 kDa

MHWIATRNAVVSFPKWRFFFRSSYRTYSSLKPSSPILLNRRYSEGISCLRDGKSLKRITTASKKVKTSSDVLTDKDLSHLVWWKERLQTCKKPSTLQLIERLMYTNLLGLDPSLRNGSLKDGNLNWEMLQFKSRFPREVLLCRVGEFYEAIGIDACILVEYAGLNPFGGLRSDSIPKAGCPIMNLRQTLDDLTRNGYSVCIVEEVQGPTPARSRKGRFISGHAHPGSPYVYGLVGVDHDLDFPDPMPVVGISRSARGYCMISIFETMKAYSLDDGLTEEALVTKLRTRRCHHLFLHASLRHNASGTCRWGEFGEGGLLWGECSSRNFEWFEGDTLSELLSRVKDVYGLDDEVSFRNVNVPSKNRPRPLHLGTATQIGALPTEGIPCLLKVLLPSTCSGLPSLYVRDLLLNPPAYDIALKIQETCKLMSTVTCSIPEFTCVSSAKLVKLLEQREANYIEFCRIKNVLDDVLHMHRHAELVEILKLLMDPTWVATGLKIDFDTFVNECHWASDTIGEMISLDENESHQNVSKCDNVPNEFFYDMESSWRGRVKGIHIEEEITQVEKSAEALSLAVAEDFHPIISRIKATTASLGGPKGEIAYAREHESVWFKGKRFTPSIWAGTAGEDQIKQLKPALDSKGKKVGEEWFTTPKVEIALVRYHEASENAKARVLELLRELSVKLQTKINVLVFASMLLVISKALFSHACEGRRRKWVFPTLVGFSLDEGAKPLDGASRMKLTGLSPYWFDVSSGTAVHNTVDMQSLFLLTGPNGGGKSSLLRSICAAALLGISGLMVPAESACIPHFDSIMLHMKSYDSPVDGKSSFQVEMSEIRSIVSQATSRSLVLIDEICRGTETAKGTCIAGSVVESLDTSGCLGIVSTHLHGIFSLPLTAKNITYKAMGAENVEGQTKPTWKLTDGVCRESLAFETAKREGVPESVIQRAEALYLSVYAKDASAEVVKPDQIITSSNNDQQIQKPVSSERSLEKDLAKAIVKICGKKMIEPEAIECLSIGARELPPPSTVGSSCVYVMRRPDKRLYIGQTDDLEGRIRAHRAKEGLQGSSFLYLMVQGKSMACQLETLLINQLHEQGYSLANLADGKHRNFGTSSSLSTSDVVSIL

MSH1

DNA mismatch repair protein MSH1, mitochondrial

959 amino acids

Important for mitochondrial DNA (mtDNA) stability and repair. Recognizes and binds to base-base and small insertion-deletion mismatches in mtDNA. ATP binding and hydrolysis is crucial for function. Binding to a mismatched base pair attenuates ATP hydrolysis. Also involved in proper sorting of mtDNA during mtDNA transmission.

Belongs to the DNA mismatch repair MutS family.

109.409 kDa

MKHFFRLPTAFRPISRVSLRYSSTDTAQPKISKLKISFNKISESNSEKKDNLGSIDTRNCLSTQQDDKLSSTEPSKASLPPSLQYVRDLMDLYKDHVVLTQMGSFYELYFEQAIRYAPELNISLTNRAYSHGKVPFAGFPVHQLSRHLKMLVNNCGYSVTIAEQFKKKDVADNEANKFYRRVTRIVTPGTFIDEAFENLRENTYLLNIEFPENCMSQVADTSLKVGICWCDVSTGEIFVQQVYLRDLVSAITRIQPKEILLDERLLEFHIESGTWYPELVELKKFFIKYQKMPSQHRTIESFYGLFNLGGKEATERQLKIQFQTFTQKELAALRNTLIYVSNHLPDFSINFQIPQRQLATAIMQIDSRTSTALELHSTVRDNNKKGSLLSSIRRTVTPSGTRLLSQWLSGPSLDLKEIKKRQKIVAFFKDNRDITETLRTMLKKVNDLSRILQKFSFGRGEALELIQMARSLEVSREIRKYLLNNTSLMKATLKSQITQLTESLNFEKNLIDDILKFLNEEELAKSQDAKQNADVTRMLDIDVKDKKESNKDEIFELRDFIVNPSFNTKLRKLHDTYQGVWQKKTEYNALLKGFFVGDLGAKTFTLKERQNGEYALHVTGTASSLKKIDELISKSTEYHGSCFHILQKSSQTRWLSHKIWTDLGHELELLNLKIRNEEANIIDLFKRKFIDRSNEVRQVATTLGYLDTLSSFAVLANERNLVCPKVDESNKLEVVNGRHLMVEEGLSARSLETFTANNCELAKDNLWVITGPNMGGKSTFLRQNAIIVILAQIGCFVPCSKARVGIVDKLFSRVGSADDLYNEMSTFMVEMIETSFILQGATERSLAILDEIGRGTSGKEGISIAYATLKYLLENNQCRTLFATHFGQELKQIIDNKCSKGMSEKVKFYQSGITDLGGNNFCYNHKLKPGICTKSDAIRVAELAGFPMEALKEAREILG

msh1

MutS protein homolog 1

941 amino acids

Involved in mitochondrial DNA repair.

Belongs to the DNA mismatch repair MutS family.

106.933 kDa

MPTWRYIFSLRSKSSFTKTWVPFTQIRNSSKSPKVGQKPILQGALGPPLDFIRPKEKVTLPPLLKEVSFQQKKFADCVLLTKVGNFYEMYFEQAEKIGPLLNLRVSKKKTSKSDVSMAGFPFFKLDRYLKILVEDLKKCVALSEEVIRPVDDLSSKNMYIRSVTRVITPGTLIDENFMNPYESNYILTVVFDPNFFSSDISNQGTAEDKDCFADCKIGLSWLDLSTGEFFTQDSNLQRLAGDLTRISPREIVLDESLKSFTTHPIYSFIQERKYFLSYVENRYQSLDCWNKFLEKEIDPSFIKYCTKLEVTAGCTLISYIADRLQNSHPNIQPPIRVSLNEYMIIGESAMKGLEIRSSLYQNRYTGSLLHAINKTVTKSGSRLLTRRLCAPSTNIVEINNRLDLVEKFKLLPELCSKVINLLKKSNDTHRILQHLLMGRGNSYDLLKMADNFSITKEIHSLLSPLESSSAFRLLLLNMHPHDELKQLINNAVDENALMKQKINEEEETEVIAQEAEEILQDENAQVEIVKKSLSSEFDIRQSFKENWVVKSNFNNNLRKLHEKLQSLFASYDKLQEDLSKRLGKKATLRKSPAKLYYVHLKLSGNETIERFIKKFTQAVLFQSTKSTASFQLPGWTSLGMDLENTKLHIHQEEQRVLKSITDEIVSHHKTLRSLANALDELDISTSLATLAQEQDFVRPVVDDSHAHTVIQGRHPIVEKGLSHKLIPFTPNDCFVGNGNVNIWLITGPNMAGKSTFLRQNAIISILAQIGSFVPASNARIGIVDQIFSRIGSADNLYQQKSTFMVEMMETSFILKNATRRSFVIMDEIGRGTTASDGIAIAYGCLKYLSTINHSRTLFATHAHQLTNLTKSFKNVECYCTNLSIDRDDHTFSFDYKLKKGVNYQSHGLKVAEMAGIPKNVLLAAEEVLTLLPNTSKPTSMK