Protein
Molybdenum cofactor biosynthesis protein 1
Organism
Dictyostelium discoideum
Function
Isoform mocs1a and isoform mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
Similarity
In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.
Sequence
MTNIIKSFITRNTYLNKLSPSPYQFNKYYSNSISTPPTHSYEKKQQPIQNVDDKKYILTDRFNRHHTYLRISLTERCNLRCKYCMPEEGVMLSQADKILTTDEIIRLSKLFVSAGVNKIRFTGGEPLVRKDVEPLIEEVGKIKGLQKIGITTNGILLSRKLDRLHKAGVNLLNISLDTLNSDKFTLITRRLGWDRVFQSIDNALKLDNIKVKVNCVIMKGLNDMEICDFVEMTRDKSVEIRFIEYMPFDGNLWSDKKFLSYTDMIKIIHEKYPTFKKYTIEEEEPNNTSKTYHVPGFKGKVGFITSMSEHFCSSCNRLRITADGNLKVCLFGNTEVNLRDRIRDGASDQQLLEIINAAVLKKKASHAGMYEIAQNKNRPMILIGEKSKIQINFKNKSIKQKKEVKNYLLKLINSSFINSNNNNNNNNNNNNNSKLQYIQQRNYSTNKNNQNLENNEFSHITKDGKLPTMVDISDKIITKRTAHAQSILEFPSNVLSQLLNLEKNNDIDNDNNISKNKEIVSKKGPVFATSIVAGTMAVKNTSNLIPFCHPIPIESCKIEITIIDSTSVKVDCIVSMSGKTGVEMEALTGATITSLTIYDMCKALSKDIVIKETKLISKFGGKSSSPQITK