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MOB2

Gene
Mob2
Protein
MOB kinase activator-like 2
Organism
Drosophila melanogaster
Length
566 amino acids
Function
Required for the normal morphogenesis of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites.
Similarity
Belongs to the MOB1/phocein family.
Mass
58.907 kDa
Sequence
MNWAISNLTGGNRVSRAILVRYSSVPLADATNDGSSTAPQTPTASTPRPSSSHSSLSSTFAATFLHASSRHIPGRAVPRQNANGQNGGKGNASGAGGGAGGGGAGGASGGTGGTGAQAAGQLSLPLDVEETVTCFCRKARRKERDGDQNSTDTKLYLEESVLERKLPEADLKALVDLPAGLDYNEWLASHTLALFEHVNLVYGTISEFCTQSGCADMTGPGNRTYLWFDEKGKKTRVAAPQYIDYVMTFTQKTVSDESIFPTKYANEFPGSFESIARKILRLQFHVIAHLYAAHFREIALLGLHTHLNLTFAHLTALHRRFNLIDEKETDVLRDLEVALRLTDDTGGCQDATSTTSSVHDHSHSGDLQHQSLQQQQQHHNSSSNSTSSAEAFHVNSQSNNGSTSASASVSLIDGDAVAPPICTQPEAGAGCKPAGSSGLLGGILGDLTSGEFGDTTRYCTSAVPQAAAAAGAGVGGTAIGATDAAALNNGAGALHLNFSNNNNNNHNLNHHHHHHHHHGHHGHHHAAQQQQQHSGLIQCNAAGGGGNATGVATGGATAAASSTTTA

Gene
MOB2
Protein
CBK1 kinase activator protein MOB2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
313 amino acids
Function
Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. The RAM network is critically required for hyphal growth as well as normal vegetative growth, and for polarization of lipid rafts and the actin cytoskeleton. It play an essential role in biofilm formation. The RAM network plays also a role in serum- and antifungal azoles-induced activation of ergosterol biosynthesis genes, especially those involved in the late steps of ergosterol biosynthesis.
Similarity
Belongs to the MOB1/phocein family.
Mass
35.384 kDa
Sequence
MSFLNTIRGLGRGSKKNKKDLEPSNNAIYSHSNLSGNGLRRTQSPTKFSPSKLSSKGAQGSAAYTSSPTKRSRTGQSLQHQDSQSSLQYQQQSGSVSPSKRSSIQTTKSTTVNADPPLFLCEPYVKTALVKGSFKTIVQLPKYVDYCEWLALNIFELFNHLNRFYGVIQEYATPEAYPTMNAGPNTNYLWVNSSGQAVNLPACQYIEYVITWVTNKLNDQSVFPTKNGGAFPPNFIKDCKNISRQMFRIFAHIYHNHFDKIIHLSLEAHWNSFFAHFISFVKEFNLIDRTEMEPLLPLIENFEQQGKITQASK

Gene
MOB2
Protein
CBK1 kinase activator protein MOB2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
287 amino acids
Function
Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.
Similarity
Belongs to the MOB1/phocein family.
Mass
33.276 kDa
Sequence
MSFFNFKAFGRNSKKNKNQPLNVAQPPAMNTIYSSPHSSNSRLSLRNKHHSPKRHSQTSFPAQKSTPQSQQLTSTTPQSQQQEASERSESQQIMFLSEPFVRTALVKGSFKTIVQLPKYVDLGEWIALNVFEFFTNLNQFYGVVAEYVTPDAYPTMNAGPHTDYLWLDANNRQVSLPASQYIDLALTWINNKVNDKNLFPTKNGLPFPQQFSRDVQRIMVQMFRIFAHIYHHHFDKIVHLSLEAHWNSFFSHFISFAKEFKIIDRKEMAPLLPLIESFEKQGKIIYN

Gene
mob2
Protein
Maintenance of ploidy protein mob2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
244 amino acids
Function
Required for coordinating polarized cell growth during interphase with the onset of mitosis.
Similarity
Belongs to the MOB1/phocein family.
Mass
28.109 kDa
Sequence
MFLLNSLSRITRGNRSKRHQNLSDASSSSGSFSKKSSTSQLVRTGSPSVEPTALYLQQPFVRTHLVKGNFSTIVSLPRFVDLDEWVALNVYELFTYLNHFYDVFATFCTVKTCPVMSAAANFDYTWLDNNRKPVHLPAPQYIEYVLAWIENRLHDQNVFPTKAGLPFPSNFLVIVKAIYKQMFRIFAHMYYAHYAEILHLSLEAHWNSFFAHFIAFGKEFQLLDKRDTAPLKDLIVVLENQGNI

Gene
MOB2
Protein
MOB kinase activator 2
Organism
Homo sapiens
Length
237 amino acids
Function
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
Similarity
Belongs to the MOB1/phocein family.
Mass
26.927 kDa
Sequence
MDWLMGKSKAKPNGKKPAAEERKAYLEPEHTKARITDFQFKELVVLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGETCQTMAVCNTQYYWYDERGKKVKCTAPQYVDFVMSSVQKLVTDEDVFPTKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYVHFILFAREFNLLDPKETAIMDDLTEVLCSGAGGVHSGGSGDGAGSGGPGAQNHVKER

Gene
Mob2
Protein
MOB kinase activator 2
Organism
Mus musculus
Length
235 amino acids
Function
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
Similarity
Belongs to the MOB1/phocein family.
Mass
26.851 kDa
Sequence
MDWLMGKSKAKPNGKKPAAEEKKVYLEPEHTKSRITDFEFKELVVLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGETCQTMAVCNTQYYWYDERGKKVKCTAPQYVDFVMSSVQKLVTDEDVFPTKYGREFPSSFESLVKKICKYLFHVLGHIYWAHFKETLALELHGHLNTLYVHFILFAREFNLLDPKETAVMDDLTEVLCSSPGNSGATGDGANSGASGAQNHVKER

Gene
mob2
Protein
MOB kinase activator-like 2
Organism
Dictyostelium discoideum
Length
217 amino acids
Similarity
Belongs to the MOB1/phocein family.
Mass
24.913 kDa
Sequence
MTLFSSLLSRVSKDGKESIRGNYKPKKHPRGSSRHTMRKSLKKNLAGGTVLKESVKCPDGEDENEWIAVNTIEIFNTMNMCYSFIQGFCTEASCPQMTGAKATYLWTDGKGKPQELSAPQYIDNLVNWISEQIDNPEIFPVDDSDFPKNYRPAVIKIISRVLRVYAHIYHAHWDHIQKLDCYQHTNTSLKHLQYFAEHFSLIGEKDLAVMKHVFDTL