Protein
Putative endoplasmic reticulum mannosidase MNL2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
Putative mannosidase involved in glycoprotein quality control since it is involved in the targeting of misfolded glycoproteins for ER-associated protein degradation (ERAD).
Similarity
Belongs to the glycosyl hydrolase 47 family.
Sequence
MSIARLVYSLFRRVRSVLLLFITISLLFYYTFQNEIDILNSYALNDSLPSINNYEHNTEGSSKLDPPDLSSTGSDRIATDKENGNVAVDLSDPATLREKNKYFPLLLKGSSHQIGSNLPISSLLTYKEKYPVLFEYSSPSLTSISQNDVHKIQPAMQLPPDVDMIKQIKDIFMKSWNQEQLLLKSNLRRESTWPIDLIDSLDTLYLCGETKLFQDSVNIIEDFDFRVPPLAMEVIDIPDITTRVLEGLLSAYELSMDKRLLNKAKHVADFILRSFDTPNRIPILKYFWKSDLRNRFPDRTVPSGQLTTMALAFIRLSQLTRLNKYFDAVERVFTTIRQSYNEFDMEFMLPDVVDASGCQLLTQEEIENGAHLKGSSIMKSINENFKFVHCQQLGKFLNPPIDDNSLQEQSQYQAYRINEKTVPILENLFKINDLFQSSYDILDGSSKNANAATMDPSIGSEVEAVDEIIEKRNFKDGTKKDSTKNTVGDKSLIDSQTFLTNSISNIFKFMTFRPMLPKQTENKKFNFLNSILTKSQFMPTTNELDVTIRKSYDVSLYSCRLGGILGLSSRVPHRGGVNTKYILPSSLLEMSEIITESCFMLMEEFDGLLPQKFELDPCTDETNGNCEFNGETKSRMIANGEYETFENDLDVGIKVSNYGKGGNDQKAKRNVLSKDGITETQNIKGDTVGSSKSIAEIDGDEVTQIRRVFTLGKDIKPHITTDDTMGSQWKNHPDWPFWVNKVESRRLLDSNIIESIFYMYRISGEQKWRSMGKQSFGILMQELMELNSGAKGLWQIKEFYENGEKVNNDLPSYWFSRTLKYYLLLFSDGDKVSLDKHILTQGGHIIKKK