MMP21

Gene

MMP21

Protein

Matrix metalloproteinase-21

Organism

Cynops pyrrhogaster

Length

616 amino acids

Function

May play a role in gastrulation-related cell movement (PubMed:11606053). Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (By similarity).

Similarity

Belongs to the peptidase M10A family.

Mass

70.428 kDa

Sequence

MPTAPALGALLLLLGALTPGHQEKLFHSRDHSDLQPSPQHQAELVTDLQSAQQFLSKYGWTEPVKWEGTSSKNAAELPRYGDADLMQEGASISRYGQEFPLEPTQAPAFVEALRKFQTLNGLPATGKLDDSTIAAMNKPRCGVPDNQIGKESAIVKSNSNNVTEKASGKSLNTTTNQNPENGTSTSKIRKKRFLQMLAAPVRYKDQANQGSTVRGAFSKKLLKWRLIGEGYSSQLSIDEQRYVFKTAFRMWSEVMPLDFEEDLTSPMSLIDVKLGFGRGRHLGCTRSFDGSGQEFAHAWFLGDIHFDDDEHFTAPSSDSGISLLKVAVHEIGHVLGLSHIYQTGSIMQPNYIPQEAGFELDWTDRKAIQMLYGTCEGSFDAVFDWIWKERNQYGELVLRYNTYFFRNAWYWLYENRKNRTRYGDPVTVSLGWHGIPAEGIDAFVHVWTWTEDATYFFKGTQYWRYDSENDQAYIKDAQGNQYPRLISEGFPKIPSPINTAFFDRRDQFIYFFKDAHVYAFDVKRNMVANHYPKRIIDVFPAVVRNNHPFGNIDAAYYAYTHNSIFLFKGKEYWKVVSDKDRQQNPKLPRNGLFLKKNISEQWTDICNVHSSMLKMR

Protein

Matrix metalloproteinase-21: MMP21

Gene

mmp21

Protein

Matrix metalloproteinase-21

Organism

Xenopus laevis

Length

604 amino acids

Function

Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway.

Similarity

Belongs to the peptidase M10A family.

Mass

70.146 kDa

Sequence

MPSIKLLVWCCLCVISPRLCHSEKLFHSRDRSDLQPSAIEQAELVKDMLSAQQFLAKYGWTQPVIWDPSSTNENEPLKDFSLMQEGVCNPRQEVAEPTKSPQFIDALKKFQKLNNLPVTGTLDDATINAMNKPRCGVPDNQMAKKETEKPTAAQSLENKTKDSENVTQQNPDPPKIRRKRFLDMLMYSNKYREEQEALQKSTGKVFTKKLLKWRMIGEGYSNQLSINEQRYVFRLAFRMWSEVMPLDFEEDNTSPLSQIDIKLGFGRGRHLGCSRAFDGSGQEFAHAWFLGDIHFDDDEHFTAPSSEHGISLLKVAAHEIGHVLGLSHIHRVGSIMQPNYIPQDSGFELDLSDRRAIQNLYGSCEGPFDTAFDWIYKEKNQYGELVVRYNTYFFRNSWYWMYENRSNRTRYGDPLAIANGWHGIPVQNIDAFVHVWTWTRDASYFFKGTQYWRYDSENDKAYAEDAQGKSYPRLISEGFPGIPSPINAAYFDRRRQYIYFFRDSQVFAFDINRNRVAPDFPKRILDFFPAVAANNHPKGNIDVAYYSYTYSSLFLFKGKEFWKVVSDKDRRQNPSLPYNGLFPRRAISQQWFDICNVHPSLLKI

Protein

Matrix metalloproteinase-21: mmp21

Gene

mmp21

Protein

Matrix metallopeptidase-21

Organism

Danio rerio

Length

599 amino acids

Function

Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway.

Similarity

Belongs to the peptidase M10A family.

Mass

68.911 kDa

Sequence

MLTVIRRIFIIQTFIFITAEKIFHSRDHSDVLNNIHQAELITDTDTAQRFLSKYGFIKAAGSEESQLSESSGDLDFSLSLDLHEGGTTSGSSSSDLQFVSALRDFQRLSDLPVTGVFDDATKAAMNKPRCGVMDDDQELKDVTGSNSTRNHIRTSTNTSHNHEHQAPVRKKRHLSALLKNTSLQKRDVSKWTGHMAFSKSVLKWRLIGEGYSSQLSIQEQKYIFRLAFRMWSEISPLQFIEDLHSPLENIDIRLGFGTGRHLGCSQRFDGAGREFAHAWFLGDIHFDDDEHFTVPNTGSGISLLKVAVHEIGHVLGLPHIYRPGSIMQPSYLPQDAGFEIDWMDRKSIQRLYGVCTGRFSTVFDWIRKEQTPYGEVVVRFNTYFMRDGLYWLYENRNNRTRYGDPVAVQVGWHGLPSGGVDAYVHVWNRKTDAVYFFKGMQYWRYDSENDHVFSHAPDGRLYPRLISEDFPGVSGPLDTAYYDRRDAHIYFFKGSQVFRFDVRMRRLASSSPQEMTEVFPAIVSGDHPVRSLDAAYFSYTHNTVFLLKGSLFWRVLSGKERRRRAFLPMNGLLAHRRVHEQWFDICDVHSSSLRTTRRR

Protein

Matrix metallopeptidase-21: mmp21

Gene

MMP21

Protein

Matrix metalloproteinase-21

Organism

Homo sapiens

Length

569 amino acids

Function

Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).

Similarity

Belongs to the peptidase M10A family.

Mass

65.043 kDa

Sequence

MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM

Protein

Matrix metalloproteinase-21: MMP21

Gene

Mmp21

Protein

Matrix metalloproteinase-21

Organism

Mus musculus

Length

568 amino acids

Function

Plays a specialized role in the generation of left-right asymmetry during embryogenesis (PubMed:26437028). May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin (By similarity).

Similarity

Belongs to the peptidase M10A family.

Mass

65.454 kDa

Sequence

MLAASVLRLTLPLCWLVAPQPTQPERLFHSRDRSDLEPSPLSQAKPIADLHDAQSFLLKYGWSEIPSPKESAGVPVGFTLAQAVRRFQKANRLPASGELDSPTLAAMNKPRCGVPDTRLPPRAALPTPPALLTSLGLRPRARQKRFLQMLFPKPDGQQEDASDTGASRAFSKKTLTWRLVGDAYSSQLSGDEQRYIFRLAFRMWSEVTPLDFREDRTAPGTMVDIKLGFGRGRHLGCPRVFDGSGQEFAHAWRLGEIHFDDDEHFTPLSSDTGISLLKVAVHEIGHVLGLPHTYRVGSIMQPNYIPQEPAFELDWADRKAIQRLYGSCKGSFDTVFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPTQSIDAYVHVWSWGKDERYFFKGSQYWRYDSENDQAHTEDEQGRSYPKLISEGFPGIPSPLDTAFYDRRQQLIYFFKESLVFAFDVNRNQVLNSYPKKMSQVFPAIMPQNHPFRNLDSAYYSYAHNSIFFFKGNSYWKVVSDKDKQQNTRLPLNGLFPKKPVSEKWFDVCDVHTSTLNM

Protein

Matrix metalloproteinase-21: Mmp21