MLP1

Protein MLP1 homolog

2085 amino acids

Involved in the structural and functional organization of perinuclear chromatin. Associates with the nuclear pore complex and form filamentous structures along the nuclear periphery.

231.069 kDa

MAAAEVDLGYLSAQANISQVDLETVVSAPTADLVKSVLAAVLSKIRELEQDKFHLNVELEGAIRGAESRCEQFKATSDKALKEVEELRQKLQSEESARRTLENELQTLKSSGSASLSEIETLRARIASLETSNRETLAIVDSKASANAALSEELQKQHQKILKLNQEINNLNQAVQTAQTAANSAKYREESLKQELELAKKNNDWYDNELKTKAAENLKIRKEKGAQIAQLQREKEDALSTIQSLQKTEQQLRKRLQEAQSKAEEALTKVQQLQESAARAEESFRQELESSKRLVELKDQQAQTHRNRLKEVELRLEKVKDDSAEEIRRVRRELEQAKEDLSQSEQQVQDLQSEVDRLRTLVESHDGVPGSVPQTPRANGSLLARPSSPFGTPASLRGKATQRATETLEELLKVKAQLASEQRRSQKLQEDLDDAVSMLEAKLPEIDELNAESERLRNEVIQMSEIMQQSYEERDAAVKAARKAEAAASQAQAEVKILRAQLRDLSTQIHVLIFNAHAKEKGMDQLTEEEIAQFERLQRGEISEGALEDLSDTHRFITERFTVFKDIYELQQKNEELLKLTRELATKMENEEALAAQRQAAQEHEEVQQLRATVAALQDEVRSITIRMKSHMTERDMFRRMLQQRATPAEIQKVLGTQADGEQREVLPSVEQPHANEAQLAAALRELQAQFDAYRNDQVTDRNAMREQIDKLSGEKGSLQSEVTKLSSQLTLATERYNMLESNFKALQSENQELQKRNQSLSEAAAKQDIRTQQVAEDLVEARGLVESLRSENANLKAEKALWRTIQERLTQDNESLAQEKTRLNGLLASQQSLLNERELSEAETKRRLQAQIDSLEAELSTTKRKLSEEIEESKKVQLRKEFDAQQFQKRIDELTSMISQVKEENIQVKTTRDHLQARVSELEIEVRNAQERAERLRPLPTPRAPAAAEQPSEEAQARIEELEGEVQELKNNLDLLTVQLEHAKQQAEQFKQLSKDMEEELSSLNESHEQYRQEMDAALASKANTINELQQRVEALTAELSNTNNELNMLRDSQSDVARKFEEKERMLNAEIARLKDEEERYKEAARFHQQDLRAQAEIATKAQQDYEQELVKHAEAAKLLQQLRAEHNELKTQAAAWRAEADSAKISLAQSEQSWEERRQRLEQEIAEIKARRDDMAAQNKLLHQQLDAVTAQITALQQKRTQGDVSGEAAAPAIADMATEGLRELNSYLRREKEILEVQYDIKVQEAKRLQQQLEYTQSQLDETRLKLEQERASQADSTRTSLTHKELMEKLNELNLIRESNVTLRNENQRAQALLEQKAARITELEAKIQPLEARIAELELDKGFKEEEIRQLQEARDGLQKRIETILSKYGQADPQEVEQLKAMIAALEGERDVLKQSEQALQQKVKEAENALETKTNEWKATREKLAEDFKARFRNMKTQRDEATNEKNTLQATLDGVKEQLAALEKELETTKQQLATATEKNTSLQQQLAASSTEQPAAAPVSAAPSDQINELTQQLQAVKQQLESVSAQKAAAEAQVEQLKQELAAAIAERDRALAATSGGDVATAETSVSAQPSAGLSDEERKALEEKIAAAEAKAAEFEKRAKELEEQADNIVKQRSDKMKTALNKKLQESKEAMEKQIQEEKAKLQAEFDLKLQQELAIIKAEQQTAGPQNGVPATPVKTEANAAPGTPVPDITNMTDAQIREAVAKNPTISAIVKSNVKRMVAAETKKIKEEIEAALKAEYEQKITNAKEQATALTEKKSALRINMLDRQHKTAQAKLAIVETAAKETPQKPVVEVWNIAKDAKPPAPAQAPAPAPASAAPSPAPTPAQPVAPATAAPAAPAQAPSAAPPKEETKQEAKTTTAAPPSAIPKPAVNPFTAPLNPFGAPAPTSNIPAPPQAGQQPQQTQPQQPQQPQQQQQQQKGQQQQQQQQQQQQGQQQQQQGQQQAGGQNQPQRMGIPVPAGRGGPGGARTARGLYQAGPRGARGGRGGGFVGAGRGAGGAAGGLNPNAGEFTPGGATATAAAAAAAGGAGGSAGAGNAGNKRQRDGEGGQPQGERGGKRARGGGGGGGGNQ

MLP1

Protein MLP1

1875 amino acids

Involved together with the closely related MLP2 in the structural and functional organization of perinuclear chromatin. MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery. According to PubMed:11862215 some telomeres are tethered to the nuclear periphery through MLP1/MLP2, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. According to PubMed:12490156 MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. MLP1 also recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself.

218.456 kDa

MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSENLKVTVSFDELKASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSELEFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLETKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIRNELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQRLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKECLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELEHKVPIINSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDLCRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNIIQLQEKNAELLKVVRNLADKLESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRIEELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRISQITRESTENMSLLNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNTILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSLRIMVTQLQTLQKEREDLLEETRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSNIEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETINDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTDEKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYESKLSKIQNDLDQQTIYANTAQNNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQLENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNGPGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHSSIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTALKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKERQGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANARIEELQNAKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQRQIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNINMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVEERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQEELKDVPHSSHISDDERDKLRAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPPKSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQNDNDKRESLANKTDPPTHLEPSFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRNVQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELKNDEDDTTENINESKKIKTEDEEEKETDKVNDENSI