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MLF1

Gene
MLF1
Protein
Myeloid leukemia factor 1
Organism
Bos taurus
Length
270 amino acids
Function
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus (By similarity).
Similarity
Belongs to the MLF family.
Mass
31.227 kDa
Sequence
MFGMLSSSFEDDPFFSDSFIAHRESMRQMMRSFSEPFGRDMLSISDRRGRARNRMGHEDEENSLTHTDVSPFQAMDRMMLNMRNSMQELQRNFGHLSMDPNGHSFSSSSVMTYSKVGDEPPKVFQASTQTRRAPGGIKETRKALRDSDSGLEKMAVGHHLHDRAHVIKKSKNNKTGDEEVNQEFINMNECDAHAFDDEWQNEILKYQPRGQWRNLDNSRMRSVAHENSGSRELKRREKHHQSPAIEHGRRSNVFVDKLNIKGSPVKINKK

Gene
MLF1
Protein
Myeloid leukemia factor 1
Organism
Homo sapiens
Length
268 amino acids
Function
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Similarity
Belongs to the MLF family.
Mass
30.627 kDa
Sequence
MFRMLNSSFEDDPFFSESILAHRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLGNTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSNVLGDKLHIKGSSVKSNKK

Gene
MLF1
Protein
Myeloid leukemia factor 1
Organism
Pongo abelii
Length
268 amino acids
Function
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus (By similarity).
Similarity
Belongs to the MLF family.
Mass
30.667 kDa
Sequence
MFRMLSSSFEDDPFFSESILAHRENMRQMMRSFTEPFGRDLLSISDGRGRVHNRRGHNDGEDSLTHTDVSSLQTVDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLENTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSDVLGDKLHIKGSSVKSNKK

Gene
Mlf1
Protein
Myeloid leukemia factor 1
Organism
Mus musculus
Length
267 amino acids
Function
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Similarity
Belongs to the MLF family.
Mass
30.432 kDa
Sequence
MFRMLSSSFEDDPFFADSFLAHRESMRNMMRSFSEPLGRDLLSISDGRGRTHNRRERDDGEDSLTHADVNPFQTMDRMMANMRSGIQELQRNFGQLSMDPNGHSFCSSSVMTYSKVGDEPPKVFQASTQTRRAPGGVKETRKAMRDSDSGLERMAVGHHIHDRGHVIRKSKNNKTGDEEVNQEFINMNESDAHAFDDEWQNEVLKYKSIGRSGNTGMRSVGHEHPGSRELKRREKIHRNSAIESGRRSNVFVDKLNVKGSPVKITKK