Protein
Large-conductance mechanosensitive channel MscMJLR
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Function
Large-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Selective for cations. Rectifies with voltage.
Similarity
Belongs to the MscS (TC 1.A.23) family.
Sequence
MTITQMISEILMHNTVYNYILSLISIILFIVIGKYANALIERLADKLHKKSGIELDELLIRALSLPVAIAIILSGFYFGVNFLYLLPSLKTAVNEGILTAFILCVVVFFDRFLNELVERYLALTISKKTKKDVDDQIVVLTKKLVRLVVWVVGLLLILSNLGYDIKTLLAGLGIGGLAVALASQNLVSNLIAGLIILTDKPFKIGNWITFSGGSGIVEDIGIRSTKIRATDNSIIVVPNSKLIDEIIQNVPSKNKWKVSTTIGVTYNTPVEKIRKAEEIIKNILLEHPNVEDEPITVYFKEFGDWSLNIQVVYYIKNSRYNGYQKYISTINEVNLKIKEEFDRKGIEFAFPTYTLYLKRDD