Protein
Mitotic interactor and substrate of PLK1
Function
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity).
Similarity
Belongs to the MISP family.
Sequence
MDRVTRYPILGIPQAHRGTGLVLDGDTSYTYHLVCTGPEASGWGQDEPQTWPTDYKAQQGVLRQGVSYSVRAYPGQPSPRGLHLETGEDEGLKVYRLGARDAHQGRPTWAVHPEDGEDEEMKTYRLDAGDAVPRGLCDLERERWAIIQGQAVRKSGTVATLQAAPDHGDPRTPGPPRSTPLEENVVDREQIDFLAARQQFLSLEQANKEVPHSSPARGTPAGPSPGVSQAPKAFNKPHLVNGHVVPTKPQGKGVFREENKVRAVPAWASVQVADDPGSLAPVESPGTPKETPIEREIRLAQEREADLREQRGLRRAADHQELVEIPSRPLLTKVSLITAPRRERGRPSLYVQRDMVQETQREEDHRREGLHVGRASTPDWVSEDPQPGLRRALSSDSILSPDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEPSAFGAFSKPSGLSTVDTEAATSPKATMSPRHLSESSGKPMSTKQEPWKLPRGSPQANRGVVRWEYFRLRPLQFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREREVAEERRNALFPEVFSPTPDESCDQNSRSSSQASGITGSYSVSESPFFSPIRLHSSLAWTVEDPVDSAPPGQRKKEQWYAGINPSDGINSEVLEAIRVTRHKNTMAERWESRIYASEEDD