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MISP

Gene
MISP
Protein
Mitotic interactor and substrate of PLK1
Organism
Pongo abelii
Length
685 amino acids
Function
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity).
Similarity
Belongs to the MISP family.
Mass
75.892 kDa
Sequence
MDRVTRYPILGIPQAHRGTGLVLDGDTSYTYHLVCTGPEASGWGQDEPQTWPTDYKAQQGVLRQGVSYSVRAYPGQPSPRGLHLETGEDEGLKVYRLGARDAHQGRPTWAVHPEDGEDEEMKTYRLDAGDAVPRGLCDLERERWAIIQGQAVRKSGTVATLQAAPDHGDPRTPGPPRSTPLEENVVDREQIDFLAARQQFLSLEQANKEVPHSSPARGTPAGPSPGVSQAPKAFNKPHLVNGHVVPTKPQGKGVFREENKVRAVPAWASVQVADDPGSLAPVESPGTPKETPIEREIRLAQEREADLREQRGLRRAADHQELVEIPSRPLLTKVSLITAPRRERGRPSLYVQRDMVQETQREEDHRREGLHVGRASTPDWVSEDPQPGLRRALSSDSILSPDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEPSAFGAFSKPSGLSTVDTEAATSPKATMSPRHLSESSGKPMSTKQEPWKLPRGSPQANRGVVRWEYFRLRPLQFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREREVAEERRNALFPEVFSPTPDESCDQNSRSSSQASGITGSYSVSESPFFSPIRLHSSLAWTVEDPVDSAPPGQRKKEQWYAGINPSDGINSEVLEAIRVTRHKNTMAERWESRIYASEEDD

Gene
MISP
Protein
Mitotic interactor and substrate of PLK1
Organism
Homo sapiens
Length
679 amino acids
Function
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.
Similarity
Belongs to the MISP family.
Mass
75.357 kDa
Sequence
MDRVTRYPILGIPQAHRGTGLVLDGDTSYTYHLVCMGPEASGWGQDEPQTWPTDHRAQQGVQRQGVSYSVHAYTGQPSPRGLHSENREDEGWQVYRLGARDAHQGRPTWALRPEDGEDKEMKTYRLDAGDADPRRLCDLERERWAVIQGQAVRKSSTVATLQGTPDHGDPRTPGPPRSTPLEENVVDREQIDFLAARQQFLSLEQANKGAPHSSPARGTPAGTTPGASQAPKAFNKPHLANGHVVPIKPQVKGVVREENKVRAVPTWASVQVVDDPGSLASVESPGTPKETPIEREIRLAQEREADLREQRGLRQATDHQELVEIPTRPLLTKLSLITAPRRERGRPSLYVQRDIVQETQREEDHRREGLHVGRASTPDWVSEGPQPGLRRALSSDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFGAFGKPSSLSTAEAKAATSPKATMSPRHLSESSGKPLSTKQEASKPPRGCPQANRGVVRWEYFRLRPLRFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREQEVAEERRNALFPEVFSPTPDENSDQNSRSSSQASGITGSYSVSESPFFSPIHLHSNVAWTVEDPVDSAPPGQRKKEQWYAGINPSDGINSEVLEAIRVTRHKNAMAERWESRIYASEEDD

Gene
Misp
Protein
Mitotic interactor and substrate of PLK1
Organism
Mus musculus
Length
648 amino acids
Function
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytoskeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity).
Similarity
Belongs to the MISP family.
Mass
72.281 kDa
Sequence
MDRVTRYPIFSNPRSARVTSLVLDEDTSYTVELVGVGPEAGWSQGDLQAWSTEYQTRPDVKRTNVSSNRRVFLGQQSPRSLYLEDEDEEIKSYHLDDSSDTLCRQRRELEAERWAVIQSQAVRKGGTVATLQAASDHGDLRIARQPQSTVTEEILVDTEQIDFLAARQQFLSLEKANTNPVPCGLTARETFPRTPPGINQAPKASTGPHLANGYTTAVTSPMKEVTLEKSFHVSPARSIHIVNDPGSQTQAESPETPKETPIEREIRLAQEREAELREQRGLGRAAGHQELVQIPSRPLLSKMSLTETPPRRDRGRPSLYVQRDMVQETQREEDHRREGLQVGRASTPDWPSQDPQPGLQRSLSSDCILSPDARATDPAPEARKVNRIPLDAYQPYLGPGTPKLEFSAFGVYSKPSGVSTEDTKATVFQKATESPRHVSESSGRSLSSKQEWSKPPGKATNVGVVRLGNFHLRPLRFKVPDVPQGTETPHTWGWEVAGGPILRLQKSQSSDLLEREMESVLRREREVAEERRNAFFPEVFSPVPAEDESHEQDSRSSSRASGITGSYSVSESPLFTPVHLNSGLVWKVEAPEDSAPPGQKTRKEMWYAGINPSDSVNSEVLGATRVKRHKNLLAERWEAHIYASEDEN