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MICAL3

Gene
MICAL3
Protein
[F-actin]-monooxygenase MICAL3
Organism
Homo sapiens
Length
2002 amino acids
Function
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
Similarity
Belongs to the Mical family.
Mass
224.295 kDa
Sequence
MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQNKVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS

Gene
Mical3
Protein
[F-actin]-monooxygenase MICAL3
Organism
Mus musculus
Length
1993 amino acids
Function
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
Similarity
Belongs to the Mical family.
Mass
223.721 kDa
Sequence
MEERKQETTNQAHVLFDRFVQATTCKGTLRAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLVQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYTDTELLLSRENVDQEALLNYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNININFLRPSQVRHLYDSGETKDIHLEMENMVNPRTTPKLTRNESVARSSKLLGWCQRQTEGYSGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLSSSDTLDLNAEEKAVLIASTKSPISFLSKLGQTISRKRSPKDKKEKDSDGAGKRRKTSQSEEEEPPRSYKGERPTLVSTLTDRRMDAAVGNQNKVKYMATQLLAKFEENAPAQSTGVRRQGSIKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEVKGALQDGPTADANGLASVAASSAERSPGTSMNGLEEPSIAKRLRGTPERIELENYRRSVRQVEELEEVPEETQAEHNLSSVLDKGTEEDVASSSSESEMEEEEEEDDEDDHLPTSDLGGVPWKEAVRIHALLKGRSEEELEASKNFEPEEEEEEEEYEEEDEEYEEEEEEESSEAGNKRLQQIITAADPLAIQADVHWTHIREREAEERMLPTSESSTSRAPLDEDDLEEDADSEPAETEGEAAEDGDPGDTGAELDDQHWSDDIPSDAEAEHRLQSQAKVKAELELRVSENEEEKPSDAPKQEERGTSQVSSPSQPPEKQVGVFSPARSPGTEEAKSPLATKVKSPEEPLFPTPLLLREKPKAEVPEEQKAVLSPIRSQPVALPEARSPTSPTSLQPESLLAPPTPPTPPPTQLPICSQPQPSSDASIPSPTKSPIRFQPVPAKTSTPLTPLPVKSQGDPKDRLSGPLAVEEVLKRSDLVEEFWMKSAEIRRSLGLTPVDRSKGSEPSLPSPASKPISLKSYSVDKSPQDEGLCLLKPPSVPKRLGLPKSAGDQPPLLTPKSPSDKELRSSQEERRDLSSSSGLGLHDSSSNMKTLGSQSFNTSDSTMLTPPSSPPPPPPPNEEPATLRRKPHQTFERREASIIPPPTPASFMRPPREPAQPPREEVRKSFVESVDEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWSRSEKLQAKENGRLPPLEQDVPPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMAKQLSRMQAMEMVSSRSHTAQSQGKELGSESTRHPSLRGTQEPTLKHEATSEEILSPPSDSGGPDGSVTSSEGSSGKSKKRSSLFSPRRNKKEKKTKGEARPPEKPSPGLPEDVVAKPKSLWKSVFSGYKKDKKKKSDEKSCSSTPSSGATVDSGQRRASPMVRAELQLRRQLSFSEDSDLSSDDILERSSQKSKREPRTYTEEELSAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLEQVEEKQRQLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEGELSEEKKILNEMLEVVEQRDSLVALLEEQRLREKEEDKDLEAAMLCKGFSLDWS

Gene
MICAL3
Protein
[F-actin]-monooxygenase MICAL3
Organism
Bos taurus
Length
1960 amino acids
Function
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
Similarity
Belongs to the Mical family.
Mass
217.545 kDa
Sequence
MEESKNEATNRAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDHRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKVCTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVNVEFRGLVEPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREHNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNVNVNFLRPSQVRHLYDTGDTKDVHLEMENLVNSRTTPKLARNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGREMASVGEPDKLSMVMYLTQFYEMFKDSLPSRDASDLNAEERAVLIASTKSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEDTPRGHRGARPTLVSTLTDRRMDVALGNQNKVKYMATQLLAKFEENAPPQSVGVRRQGSIKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEHCATTLRLSAYAYALEDGKFYCKPHYCYRLSGPAQRKRPAGVPLSGKEARGPLQDSPAADASGRPSTSASPAERSPGPSVNGLEEPSVAKRLRGTPERIELENYRLSVRQAEGLEEVPEETQAEHNLSSVLDTGTEEDAASSSSESEMEEEEPPLPTSDLGGVPWKEAVRIHALLRGKSEEELEASRSFGAGEEEEEDEEDEEEEEEEEDEEDEEEDEDESSEVGSPRRLQQLLNPADPLEIQADVHWTHIRESQEERAALAPKSPLPGVPFDEDDLERDVDSEPAEIKGEAAENGDAGDTGAELDDDQHWSDDVPSEANTELHLPAVGAELELRVSDGEEEPPPASVGHPERGPSRVSSPTRSPEEPTGLSSPARSPGAQSAHPPLAAVATGVRSPAESPLPEPSTPPAEPEAHPPIRSQPEARTPPSPASPQRPSPPTQLPICSQPQPSPEATVPSPTLSPIRSQPVPARTSTPLAPLPVKNQGVTKDTLGSSLPGDEALKRSDLVAEFWMKSAEIRRSLGLTPVHRSPGSELAFQSPPLKACPAEKAPQSEGLRLLKPPPVPRKLGLPAAEGAQPCPPTPVSPPDREPKGPREEHRDLSSSSGLGLQGSSSRTRTPGSQSFNTSDSTMLTPPSSPPPPPPDEEPATLHRKPALAGQLVASAPPPPAVCVRPPREPTQPPQEEARKSFVESVDEIPFADDVEDTYDDNTCDDRTEDSSLQETFFTPPSHWPHPKQPLAPENGRGPESAVPLQKRGLPLVSAEAKELAAERMRAREKSVRSQALRDAMARQLSRMKEMDIAAAAPRTPRTPAPRRATAVPPKGPEEPAPRHEATSEELLSPPSDSGGPDGSVTSSEGSSGKSKKRSSLFSPRRSKKEKKPKGEGRPLERPSPGTLEEAAAKPRSLWKSVFSGYRKDKKKSDGRSCPSTPSSGTTVDAGKPRASPVSRAELRTRRQLSCSEDSDLSSDDVLERTSQKSRKEPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLEQVEEKQRQLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELAEEKRILNEMLEVVEQRDALVALLEEQRLREKEEDKDLEAAMLSKGFSLHWS