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MIB2

Gene
MIB2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Homo sapiens
Length
1013 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
109.939 kDa
Sequence
MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV

Gene
MIB2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Homo sapiens
Length
1013 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
109.939 kDa
Sequence
MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV

Gene
Mib2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Mus musculus
Length
973 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
105.961 kDa
Sequence
MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLRCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPSCLVAYRPEEDANLDVAERARENKSAASVSVAGSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQASYHPALVVDTKNQGRTALQVAAYLGQVELVRLLLQARASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTALHVAVQRGFLEVVKILCERGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCSVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGCTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLILFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV

Gene
Mib2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Mus musculus
Length
973 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
105.961 kDa
Sequence
MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLRCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPSCLVAYRPEEDANLDVAERARENKSAASVSVAGSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQASYHPALVVDTKNQGRTALQVAAYLGQVELVRLLLQARASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTALHVAVQRGFLEVVKILCERGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCSVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGCTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLILFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV

Gene
Mib2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Rattus norvegicus
Length
971 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
105.542 kDa
Sequence
MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPACLVACRPEEDANLGVAERARENKSAASVPVAGSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQAGFHPAVDTKNQGRTALQVAAYLGQVELVRLLLQARASVDLLDEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRSTALHVAVQRGFLEVVKILCEHGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCNVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGSTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVIISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV

Gene
Mib2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Rattus norvegicus
Length
971 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
105.542 kDa
Sequence
MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPACLVACRPEEDANLGVAERARENKSAASVPVAGSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQAGFHPAVDTKNQGRTALQVAAYLGQVELVRLLLQARASVDLLDEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRSTALHVAVQRGFLEVVKILCEHGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCNVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGSTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVIISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV

Gene
MIB2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Gallus gallus
Length
954 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
106.34 kDa
Sequence
MDLDPYASMQVGMRVVRGVDWKWGSQDSGEGNVGTVVEIGRTGSPTTPDKTVVVQWDQGNRTNYRTGFQGAYDLLLYDNAQIGVRHPNIICDCCKKHGIRGMRWKCKMCFDYDLCTQCYMNNKHDLSHAFERYETAHSQPVLVSPRQNLTRITLKGTFQGAKVVRGPDWEWGNQDGGEGKTGRVVDIRGWDVETGRSVASVTWSDGTTNVYRVGHKGKVDLKCTVEASGGFYYKEHLPKLGKPAELQRKESTDRHPFQHGDKVKCLLDIDILREMQEGHGGWNPKMAEFIGQTGTVHRITDRGDVRVQFNSETRWTFHPGALTKLNTFWVGDVVRVIDDMETVKRFQPGHGEWTDEMAPTLGHIGKVIKVYGDGDLRVSVGDQSWTFNPACLTAYQRDEEANLMTTENAKESKSTLITVLEKLLSQKTESDHAGCLVIWAALNNAAKVRELLQKYPDKVDNKNQGRTALQIASYQGHLDVVKILLQAHATVNLRDEEGDTALHYAAFGNQADVARVLMAKGAGADLLNNAKCTALYVAVSQGFTEVVQALCELNCDVNLPDSHGDTPLHYAITADYKVIIEILTEVPNIDFTVQNCQGFNLLHYSALKGNKLAIKKILARARQLVDSKKEDGFTALHLAALNNHKEVAEILIKEGRCDVNVKNNRNQTPLHLAIIQGHVGLVQLLVSEGSDVNAEDEDGDTAMHIALERQQLMSVLMEKREGEMGSSLFSKLQASGFLGNVELNVGTAIACYLAQEGADINYANHRGKSPLDLITDGRIVQIIKDFSQKFREQQVSSDCSAITCSLRRVHTTPNTMTNLSVSSVAVPTECLVCSELALLIHFFPCQHSIVCEECSRRMKKCIKCQVTITKKLKRDSTEVECSPSSESTDQRKLMEELQNRYRQMEERITCPICIDDQIKLVFQCGHGSCPDCSTALTVCPICRQAIRERIQIFV

Gene
MIB2
Protein
E3 ubiquitin-protein ligase MIB2
Organism
Gallus gallus
Length
954 amino acids
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Mass
106.34 kDa
Sequence
MDLDPYASMQVGMRVVRGVDWKWGSQDSGEGNVGTVVEIGRTGSPTTPDKTVVVQWDQGNRTNYRTGFQGAYDLLLYDNAQIGVRHPNIICDCCKKHGIRGMRWKCKMCFDYDLCTQCYMNNKHDLSHAFERYETAHSQPVLVSPRQNLTRITLKGTFQGAKVVRGPDWEWGNQDGGEGKTGRVVDIRGWDVETGRSVASVTWSDGTTNVYRVGHKGKVDLKCTVEASGGFYYKEHLPKLGKPAELQRKESTDRHPFQHGDKVKCLLDIDILREMQEGHGGWNPKMAEFIGQTGTVHRITDRGDVRVQFNSETRWTFHPGALTKLNTFWVGDVVRVIDDMETVKRFQPGHGEWTDEMAPTLGHIGKVIKVYGDGDLRVSVGDQSWTFNPACLTAYQRDEEANLMTTENAKESKSTLITVLEKLLSQKTESDHAGCLVIWAALNNAAKVRELLQKYPDKVDNKNQGRTALQIASYQGHLDVVKILLQAHATVNLRDEEGDTALHYAAFGNQADVARVLMAKGAGADLLNNAKCTALYVAVSQGFTEVVQALCELNCDVNLPDSHGDTPLHYAITADYKVIIEILTEVPNIDFTVQNCQGFNLLHYSALKGNKLAIKKILARARQLVDSKKEDGFTALHLAALNNHKEVAEILIKEGRCDVNVKNNRNQTPLHLAIIQGHVGLVQLLVSEGSDVNAEDEDGDTAMHIALERQQLMSVLMEKREGEMGSSLFSKLQASGFLGNVELNVGTAIACYLAQEGADINYANHRGKSPLDLITDGRIVQIIKDFSQKFREQQVSSDCSAITCSLRRVHTTPNTMTNLSVSSVAVPTECLVCSELALLIHFFPCQHSIVCEECSRRMKKCIKCQVTITKKLKRDSTEVECSPSSESTDQRKLMEELQNRYRQMEERITCPICIDDQIKLVFQCGHGSCPDCSTALTVCPICRQAIRERIQIFV