Protein
Aspartic protease pepA
Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)
Function
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.
Similarity
Belongs to the peptidase A1 family.
Sequence
MVLITQLGAALAVFSALTVAAPTKGKARFSAPQVGIPKKAKHHPAAAYARALHKFGMKIPKAVSDAAKGSVPTTPTQNDEQYVTQVTVGGSTLNLDLDTGSADLWVFSTETPQDESQGHNIYKPSSGAKRLDGYSWEIKYGDSSSAHGDVFLDTVTVGGVTTSSQAVESAKEVSSQFVKDKATDGLMGLSFSVLNTVQPQPQKTFFDNVLSQLEQPLFTCTLKHGEPGTYDFGYIDDSKHTGEIAYTQVDNSNGWWGFTADGYSIGGGSNSSYSLYGAQHKRANGGSISGIADTGTTLMLLSDDVVGDYYQNVQGATQDQMQGGWVFPCDANLPDFILNIGGYNAVVPGKFMNFQEIDNSMCFGGLQSSGGGSTPNIFGDVFLKSQFVVWDTQGPRIGFAPQA