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MGAT4C

Gene
MGAT4C
Protein
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Organism
Homo sapiens
Length
478 amino acids
Function
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).
Similarity
Belongs to the glycosyltransferase 54 family.
Mass
56.061 kDa
Sequence
MFKFHQMKHIFEILDKMRCLRKRSTVSFLGVLVIFLLFMNLYIEDSYVLEGDKQLIRETSTHQLNSERYVHTFKDLSNFSGAINVTYRYLAATPLQRKRYLTIGLSSVKRKKGNYLLETIKSIFEQSSYEELKEISVVVHLADFNSSWRDAMVQDITQKFAHHIIAGRLMVIHAPEEYYPILDGLKRNYNDPEDRVKFRSKQNVDYAFLLNFCANTSDYYVMLEDDVRCSKNFLTAIKKVIASLEGTYWVTLEFSKLGYIGKLYHSHDLPRLAHFLLMFYQEMPCDWLLTHFRGLLAQKNVIRFKPSLFQHMGYYSSYKGTENKLKDDDFEEESFDIPDNPPASLYTNMNVFENYEASKAYSSVDEYFWGKPPSTGDVFVIVFENPIIIKKIKVNTGTEDRQNDILHHGALDVGENVMPSKQRRQCSTYLRLGEFKNGNFEMSGVNQKIPFDIHCMRIYVTKTQKEWLIIRSISIWTS

Gene
MGAT4C
Protein
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Organism
Macaca fascicularis
Length
478 amino acids
Function
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).
Similarity
Belongs to the glycosyltransferase 54 family.
Mass
56.089 kDa
Sequence
MFKFHQMKHIFEILDKMRCLRKRSTVSFLGVLVIFLLFMNLYIEDSYVLEGDKQLIRETSTHQLNSERYVHTFKDLSNFSGAINVTYRYLAATPLQRKRYLTIGLSSVKRKKGNYLLETIKSIFEQSSYEELKEISVVVHLADFNSSWRDAMVQDITQKFAHHIIAGRLMVIHAPEEYYPILDGLKRNYNDPEDRVKFRSKQNVDYAFLLNFCANTSDYYVMLEDDVRCSKNFLTAIKKVIASLEGTYWVTLEFSKLGYIGKLYHSHDLPRLAHFLLMFYQEMPCDWLLTHFRGLLAQKNVIRFKPSLFQHMGYYSSYKGTENKLKDDDFEEESFDIPDNPPASLYTNMNVFENYEASKAYSSVDEYFWGKPPSTGDVFVIVFENPIIIKKIKVNTGTEDRQNDILHHGALDVGENVMPSKRRRQCSTYLRLGEFKNGNFEMSGVNQKIPFDIHCMRIYVTKTQKEWLIIRSISIWTS

Gene
Mgat4c
Protein
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Organism
Mus musculus
Length
478 amino acids
Function
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).
Similarity
Belongs to the glycosyltransferase 54 family.
Mass
56.25 kDa
Sequence
MLKFYQMKYIFQILDKMRCLRKRSTVSFLGVLVVFLLFMNLYIEDSYVLEGDKQLIRETSTHQLNSERYVHTFKDLSNFSGTINVTYRYLAATPLQRKRYLTIGLSSVKRKKGNYLLDTIKSIFEQSSYEELKEISVVVHLADFNSSWRDAMVQDITQKFAHHIIAGRLMVIHAPEEYYPVLDGLKRNYNDPEDRVRFRSKQNVDYAFLLNFCANTSDYYVMLEDDVRCSRNFLTAIKKVIASLEGTYWVTLEFSKLGYIGKLYHSHDLPRLAHFLLMFYQEMPCDWLLTHFRGLLAQKNVIRFKPSLFQHMGYYSSYKGTENKLKDDDFEEESFDIPDNPPASFYTNMNVFENYEASKAYSSVDEYFWGKSPSMGDTFVIVFENPITIKKIKVNTGTEDRQNDILQHGALDVGEKLIFSKQIRQCDTYLRLGEFKNGYFEMSDVNQKIPFDIHCMRICVTKTQKEWLIIRSISIWTS

Gene
MGAT4C
Protein
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Organism
Sus scrofa
Length
478 amino acids
Function
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).
Similarity
Belongs to the glycosyltransferase 54 family.
Mass
56.312 kDa
Sequence
MFKFHQVKHIFEILDKMRCLRKRFTVSFLGVLVIFLLFMNLYIEDSYVLEGDKQLVRETSIHQLNPERYVHTFKYLSNFSGTINVTYRYLAVMPFQRKRFLTIGLSSVRRKKGNYLLETIKSIFEQSSYEELKEISVVVHLADFNSSWREVMVQDITQKFAHHIIAGRLMVIHAPEEYYPVLNGLKRNYNDPEDRVRFRSKQNVDYAFLLNFCANISDYYVMLEDDVRCSKNFLTAIKKVITSLQGTYWVTLEFSKLGYIGKLYHSHDLPRLAHFLLMFYQEMPCDWLLTHFRGLLAQKNVIRFKPSLFQHMGYYSSYKGTENKLKDDDFEEELIDLPDNPPASLYTNMSVFENYDASKAYSSVDGYFWGKPPSTGDVFVVVFENPVIIKKIKVSTGTEDRQNDILHHGALDVGGYIRYFKQNRQCITYIRLGEFKNGNFEVSDVNQKIPFDVHCMRIHVTKTQKEWLIIRSISIWTS

Gene
MGAT4C
Protein
Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Organism
Gallus gallus
Length
464 amino acids
Function
Glycosyltransferase that catalyzes the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (also named 'GnT-VI' activity). May also participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans by catalyzing the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans.
Similarity
Belongs to the glycosyltransferase 54 family.
Mass
52.82 kDa
Sequence
MRCSPKRSLTAVIAASFLLLLLLLLLHRGSWQDPQEVQFRDLPSDAVLKILKQGSLHILQDTDNLCALHNISYHLLAGSPLPHKKFLAVGLSSVRRPRGYYLPDTLQSLFKQSSEEELQEMVVVVHLADADPIWNAQVAADISHRFAHHILLGRLVLIHTPHEFYPTLEGLKRNYNDPEERVKFRSKQNVDYAFLFTFAANLSSYYLMIEDDVWSAKSFFTAIRKAVASQEGSNWATLEFSKLGYIGKLYRSSDLPRLARFLLLFYQEMPCDWLLTHFRLLLTQKDVIRFKPSLFQHMGLYSSFQGTVNRLEDDEFQADAMDLPDNPPAALFTNMVVFENYEPSKAYSTARGYFWGKNPAVGSIFSIVFHQPARVTRVRVQTGSSERPGDFLHAGVLELGRGRRADGRDCSVYTTVGTFEKGNLEWRGLEKGMPNPVECVRIRVTQSQSEWLIIQSIGIWTAGT

Gene
mgat4c
Protein
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Organism
Danio rerio
Length
454 amino acids
Function
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans (By similarity).
Similarity
Belongs to the glycosyltransferase 54 family.
Mass
52.254 kDa
Sequence
MRCHLKKWVVVAAGLSILTSLYVYMQRAQSGNLKGSVIWTWDRESWMEGIKSHYLHFNISINVLGGVLQPSKKYLTVGLSSVRREKGFYLHDTLQSIFSESSEEELDQMVVVVLLADFDLPWIQQTADKISREFAVQLSKGRLLVIHANKEHYPPLTGLKRNFNDAPDRVSFRSKQNVDYSFLLHFSSNLSQYYIMLEDDVGCSRNFLSSIQQHIRSMTDSKWVTLEFSKLGYIGKLYQSKDLPTLARFLYNFYQEMPCDFLLSHFRRLLMQDKVIRFRPSLFQHMGTYSSFRGTYNRLKDEDFVQELADNPPADVRTNIQVFQTYVPEKAYSQDVEYFWGVSPIGTESFFLVVFREAVRISRVQIHTGSDGKDELASADVELGRVLVTGEPAVDCSGFKTLGSLQHGQFNEEGVQKLLPDAVVCLRIRVTAAQPEWVIISRIQVWTVKEDKTI