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METAP2

Gene
METAP2
Protein
Methionine aminopeptidase 2
Organism
Homo sapiens
Length
478 amino acids
Function
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Similarity
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Mass
52.892 kDa
Sequence
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Gene
Metap2
Protein
Methionine aminopeptidase 2
Organism
Mus musculus
Length
478 amino acids
Function
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Similarity
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Mass
52.922 kDa
Sequence
MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Gene
Metap2
Protein
Methionine aminopeptidase 2
Organism
Rattus norvegicus
Length
478 amino acids
Function
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Similarity
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Mass
53.052 kDa
Sequence
MAGVEEASSFGGHLNRDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAGQQELDKESGTSVDEVAKQLERQALEEKEKDDDDEDGDGDGDGAAGKKKKKKKKKRGPRVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Gene
METAP2
Protein
Methionine aminopeptidase 2
Organism
Bos taurus
Length
477 amino acids
Function
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Similarity
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Mass
52.812 kDa
Sequence
MAGVEEAASCGSHLNGDLDPDEREEGAASTAEEAAKKKKRKKKKSKGAATGQQEPDKEAGASVDEVTRQLERQALEEKEKDDDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKMEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Gene
metap2
Protein
Methionine aminopeptidase 2
Organism
Dictyostelium discoideum
Length
436 amino acids
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Similarity
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Mass
48.561 kDa
Sequence
MSEIQPKTEVPPKTVEEEEESDDEEDNTKVTEGGNPTGGEGAAKKKKKKNKKKKKAAPVASAADIIDSKPIPSGLVQTNPPTIPVSKQFSNGVYPMGEIQEYRDSNSYRTTSEEKRLEERIHANIYNDVRRAAEVHRQVRKYVQGIVKPGLGLTELVESLENASRTLIEADGLKAGIAFPTGVSLNHIAAHFTPNTGDKTVLKKDDVLKIDFGTHVNGYIIDCAFTVTFDEKYDKLKDAVREATNTGIYHAGIDARLGEIGAAIQEVMESHEIELNGKTYPIRSIRNLNGHSIRPYVIHGGKTVPIVRGGEMTKMEEGEFYAIETFGSTGRAQVIEDLECSHYMKTDYQTTVRLPKAKQLLQYINKNYDTLCFCRRWLDRAGEDKHILALNNLCDLGIIQRHAPLVDSKGSYVAQYEHTLLLKPTAKEVLSRGDDY