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MESD

Gene
mesD
Protein
Mesentericin-Y105 transport/processing ATP-binding protein MesD
Organism
Leuconostoc mesenteroides
Length
722 amino acids
Function
Involved in the export process of the bacteriocin mesentericin-Y105.
Similarity
Belongs to the ABC transporter superfamily.
Mass
79.916 kDa
Sequence
MVKTPMFHKKIDYISQVDERDCGVAALAMILAHYKTRLSLAKLRDLAKTDMEGTTALGIVKAANALDFETMPIQADLSLFDKKDLPYPFIAHVIKEGKYPHYYVVYGMKGDQLLIADPDNTVGKTKMTKAHFNEEWTGVSIFIAPNPTYKPTKEKKRSLTSFIPVITRQKLLVINIVIAALLVTLVSILGSYYLQGIIDTYIPNNMKNTLGIVSLGLIFAYVIQQLLSYARDYLLIVMGQRLSIDIILSYIKHIFELPMSFFATRRTGEIVSRFTDANAIIEALASTMLSVFLDLGILVIVGTVLVVQNSTLFLISLIAIPAYALVVWLFMRPFSKMNNDQMQAGSMLSSSIIEDINGVETIKALNSEATAYHKIDHEFVTYLEKSFVYAKTEAVQNAIKSLLQLSLNVVILWVGAQLVMTNKISVGQLITYNALLGFFTDPLQNIINLQTKLQQASVANNRLNEVYLVDSEFKDSHQMTEKITPNSSLVADHITYKYGFGAPAIDDVSLTITAGEKIALVGISGSGKSTLVKLLVNFFQPESGTISLGPTPLANLDKHELRGHINYLPQEPFIFSGSIMENLLLGAKPGTTQEDIIRAVEIAEIKDDIEKMSQGFGTELAESGNISGGQKQRIALARAILVDSPVLILDESTSNLDVLTEKKIIDNLMKLTEKTIIFVAHRLTISQRVDRILTMQSGKIIEDGTHDTLLKAGGFYASLFNH

Gene
MESD
Protein
LRP chaperone MESD
Organism
Homo sapiens
Length
234 amino acids
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).
Similarity
Belongs to the MESD family.
Mass
26.077 kDa
Sequence
MAASRWARKAVVLLCASDLLLLLLLLPPPGSCAAEGSPGTPDESTPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKKEGDLKSRSSKEENRAGNKREDL

Gene
MESD
Protein
LRP chaperone MESD
Organism
Pongo abelii
Length
234 amino acids
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
Similarity
Belongs to the MESD family.
Mass
26.12 kDa
Sequence
MAASSWARKAVVVLCASDLLLLLLLLPPPGSCAAEASPGTPDESTPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGNYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKKEGDLKSRSSKEDNRARNKREDL

Gene
MESD
Protein
LRP chaperone MESD
Organism
Bos taurus
Length
232 amino acids
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
Similarity
Belongs to the MESD family.
Mass
25.977 kDa
Sequence
MAASGWARAAVIFLCACDLLLLLLLPPRAFATEGPAETPGEATPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSQIDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGGYAWEIKDFLVSQDRCADVTLEGQVYPGKGGGSKEKNQTKQEKGKKKKERDLKPRASKEDNRAGSKKEEL

Gene
Mesd
Protein
LRP chaperone MESD
Organism
Mus musculus
Length
224 amino acids
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (PubMed:12581525). Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (PubMed:24140340). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (PubMed:27184668).
Similarity
Belongs to the MESD family.
Mass
25.207 kDa
Sequence
MAASRWLRAVLLFLCASDLLLLPPPNAYAADTPGEATPPPRKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVSQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKAKKKEGDPKPRASKEDNRAGSRREDL

Gene
Mesd
Protein
LRP chaperone MESD
Organism
Rattus norvegicus
Length
224 amino acids
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
Similarity
Belongs to the MESD family.
Mass
25.216 kDa
Sequence
MAASSWLRAVLLFLCASDLLLLSPPEAYATDTPGEAITPPRKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKGKTLMMFVTISGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVNQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKGKKKEGDPKPRASKEDNRAGSRREDL

Gene
mesd
Protein
LRP chaperone MESD
Organism
Gallus gallus
Length
220 amino acids
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).
Similarity
Belongs to the MESD family.
Mass
24.692 kDa
Sequence
MAAAARWAALGLALWLCAAAHAEEPEGKRRAGPAKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPPAPIDFSKIDPGKPESILKLTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSNRAIFMLRDGGYAWEIKDFLISQERCADVTLEGQVYPGKGADGSEKGRNKTKPEKAKKKKDAEKSKSSHEDNRAQTKQREDL

Gene
mesd
Protein
LRP chaperone MESD
Organism
Danio rerio
Length
206 amino acids
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).
Similarity
Belongs to the MESD family.
Mass
23.307 kDa
Sequence
MASSVGCRTLSVLFLLVLFITVHCTDTKPKKKKDIRDYNDADMARLLEEWEKDDDIEEGDLPEHKRSPPPIDFSKIDASKPEELLKMSKKGKTLMVFASVSGNPTEKETEEITGLWQGSLFNANYDVQRFVVGSNRVIFMLRDGSYAWEIKDFLVSQDRCEDVTVEGQVFPGKNAKKDAKGKEQNETKKKGDKKAANRANKGKQEL