MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Trichophyton equinum

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.366 kDa

Sequence

MHGLLLAGLLALPMNVLAHPAEQHASNVLSRRGVDIESFRLPLKAKYMDSDAAAQKIQAMSFSKDDDYVSTATKLVKSTFPKSTFRVVDDHYTGTNGIGHVHFKQTAHGLDIDNSDFNVNIDRDGKVFSFGNSFFTGEIPKENPMVKRAFSDPVKALKGAVKALNLPVKSDNAKAKTTAGKESFEFMGTTGALSAPKANLVYLQKEDGTLALTWRVETDVGDNWLLTYVDAHNSETVHNVVDYVASAEFKVFAWGLNDPTEGNPTSIRDPWTDSSPYTWHSDGMTKYPTTRGNNAIAQDNPTGGSTYINNYRPQSPNLIFNYPWSPTATPPSSYKDFSITQLFYTTNRFHDLLYSFGFNEAAGNFQVNNGNKGGRGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYAHGLSNRLCGGPANSGCLNALESGGMGEGWGDFYATAIRLKPRDTKDTNYSMGAWAANNPKGIRAYLYSTNLQTNPYMYTSVNSLREVHQIGTVWATMLYDLMWALIEAHGGTYSANPVFRNGVPQDGRHLAMKLVMDGMALQPCNPNFVQARDAILDADRALTNSANKCTIWKAFAKRGLGYGAKYDARNRTGSNRLPPGC

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Trichophyton rubrum

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.341 kDa

Sequence

MHGLLLAGLLALPMNVLAYPAEQHASNVLSRRGVDIESFRLPLKAKYMDSEATAQKIQAMSFSKDDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIGRDGKVFSFGNSFFTGEIPKENPMVKRAFSDPVKALKGAVKALNLPVKSDNAKPKTIAGKESFEFMGTTGALSAPKANLVYLQKEDGTLALTWKVETDVGDNWLLTYVDAHNSETVHNVVDYVASAEYKVFAWGLNDPTEGNPTSIRDPWTDASPYTWNSDGMSKYPTTRGNNAIAQDNPTGGSTYINNYRPQSPNLIFSYPWSPTATPPSSYKDFSITQLFYTTNRYHDLLYSFGFNEAAGNFQVNNGNKGGKGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYTHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKNTNYSMGAWAANNPKGIRAYLYSTNLQTNPYMYTSVNSLREVHQIGTVWASMLYDLMWALIEAHGGTYSANPVFRNGVPQDGRHLSMKLVMDGMALQPCNPNFVQARDAILDADRALTNSANKCTIWKAFAKRGLGYGAKYDARNRTGSNKLPPGC

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Trichophyton tonsurans

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.378 kDa

Sequence

MHGLLLAGLLALPMNVLAHPAEQHASNVLSRRGVDIESFRLPLKAKYMDSDAAAQKIQAMSFSKDDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIDRDGKVFSFGNSFFTGEIPKENPMVKRAFSDPVKALKGAVKALNLPVKSDNAKAKTTAGKESFEFMGTTGALSAPKANLVYLQKEDGTLALTWRVETDVGDNWLLTYVDAHNSETVHNVVDYVASAEFKVFAWGLNDPTEGNPTSIRDPWTDSSPYTWHSDGMTKYPTTRGNNAIAQDNPTGGSTYINNYRPQSPNLIFNYPWSPTATPPSSYKDFSITQLFYTTNRFHDLLYSFGFNEAAGNFQVNNGNKGGRGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYAHGLSNRLCGGPANSGCLNALESGGMGEGWGDFYATAIRLKPRDTKDTNYSMGAWAANNPKGIRAYLYSTNLQTNPYMYTSVNSLREVHQIGTVWATMLYDLMWALIEAHGGTYSANPVFRNGVPQDGRHLAMKLVMDGMALQPCNPNFVQARDAILDADRALTNSANKCTIWKAFAKRGLGYGAKYDARNRTGSNRLPPGC

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Probable extracellular metalloproteinase 3

Organism

Trichophyton verrucosum (strain HKI 0517)

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.246 kDa

Sequence

MHGLLLAGLLALPMNVLAHPAEQHASNVLSRRGVDIESFRLPLKAKYMDSDATAQKIQAMSFSKDDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIGRDGKVFSFGNSFFTGEIPKENPMVKRAFSDPVKALKGAVKALNLPVKSDNAKAKTAAGKEAFEFMGTTGALSAPKANLVYLQKEDGSLALTWKVETDVGDNWLLTYVDAHNSETVHNVVDYVASAEYKVFAWGLNDPTEGNPTSIRDPWTDASPYTWNSDGMTKYPTTRGNNAIAQDNPTGGSTYINNYRPQSPNLIFSYPWSPTATPPSSYKDFSITQLFYTTNRYHDLLYSFGFNEAAGNFQVNNGNKGGRGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYTHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKDTNYSMGAWAANNPKGIRAYLYSTNLQTNPYMYTSVNSLREVHQIGTVWASMLYDLMWALIEAHGGTYSADPVFRNGVPQDGRHLSMKLVMDGMALQPCNPNFVQARDAILDADRALTNSANKCTIWKAFAKRGLGYGAKYDARNRTGSNKLPPGC

Protein

Probable extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Probable extracellular metalloproteinase 3

Organism

Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.248 kDa

Sequence

MHGLLLAGLLALPMNVLAHPAEQHASNVLSRRGVDIESFRLPLKAKYMDSDATAQKIQAMSFSKDDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIGRDGKVFSFGNSFFTGEIPKENPMVKRAFSDPVKALKGAVKALNLPVKSDNAKAKTAAGKESFEFMGTTGALSAPKANLVYLQKEDGSLALTWKVETDVGDNWLLTYVDAHNSETVHNVVDYVASAEYKVFAWGLNDPTEGNPTSIRDPWTDASPYTWNSDGMTKYPTTRGNNAIAQDNPTGGSTYINNYRPQSPNLIFSYPWSPTATPPSSYKDFSITQLFYTTNRYHDLLYSFGFNEAAGNFQVNNGNKGGKGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYTHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKDTNYSMGAWAANNPKGIRAYLYSTNLQTNPYMYTSVNSLREVHQIGTVWASMLYDLMWALIEAHGGTYSADPVFRNGVPQDGRHLTMKLVMDGMALQPCNPNFVQARDAILDADRALTNSANKCTIWKAFAKRGLGYGAKYDARNRTGSNKLPPGC

Protein

Probable extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Arthroderma benhamiae

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.32 kDa

Sequence

MHGLLLAGLLALPMNVLAHPAEQHASNVLSRRGVDIESFRLPLKAKYMDSDAAAQKIQAMSFSKDDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIGRDGKVFSFGNSFFTGEIPKENPMVKRAFSDPVKALKGAVKALNLPVKSDNAKAKTTAGKESFEFMGTTGALSAPKANLVYLQKEDGTLALTWRVETDVGDNWLLTYVDAHNSETVHNVVDYVASAEFKVFAWGLNDPTEGNPTSIRDPWTDSSPYTWHSDGMTKYPTTRGNNAIAQDNPTGGSTYINNYRPQSPNLIFNYPWSPTATPPSSYKDFSITQLFYTTNRFHDLLYSFGFNEAAGNFQVNNGNKGGRGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYAHGLSNRLCGGPANSGCLNALESGGMGEGWGDFYATAIRLKPRDTKDTNYSMGAWAANNPKGIRAYLYSTNLQTNPYMYTSVNSLREVHQIGTVWATMLYDLMWALIEAHGGTYSANPVFRNGVPQDGRHLAMKLVMDGMALQPCNPNFVQARDAILDADRALTNSANKCTIWKAFAKRGLGYGAKYDARNRTGSNRLPPGC

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)

Length

633 amino acids

Function

Secreted metalloproteinase that allows assimilation of proteinaceous substrates and probably acts as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.329 kDa

Sequence

MHGLLLAGLLALPMNVLAHPAEHHASNVLSRRGVDIDSFRLPLKAKYMDNEAAAEKIQALSFTKDDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIDRDGKVFSFGNSFFTGEIPKENPMVKRAFSDPVKALKGAVKALSLPVKSDNAKAKNVAGKETVEFMGTSGALSAPKAKLVYLQKDDGTLALTWRVETDVGENWLLSYVDANNSETVHNVVDYVASAEYKVFAWGLNDPTEGNPTSIRDPWTDASPYTWNSDGNTKYPTTRGNNAIAQDNPTGGSQYLNNYRPQSPNLIFSYPWSATATPPSSYKDFSITQLFYTTNRFHDLLYSFGFNEAAGNFQVNNGNKGGRGNDFAIVNAQDGSGTNNANFATPPDGQPGRMRMYNWTTARPNRDGCLEAGIVIHEYAHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKNTNYSMGAWAANNPKGIRAYLYSTSLQTNPYMYTSVNSLREVHQIGTVWASMLYELMWALIEAHGNTYSANPVFRNGVPQDGRHLAMKLVMDGMALQPCNPNFVQARDAIIDADRALTNSANKCTIWKAFAKRGLGYGAKYDSRNRTGSNQLPPGC

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.377 kDa

Sequence

MHGLLLAGLLALPMNVLAHPAEQQTSSVLSRRGVDIDSFRLPLKAKYMDSDATAQKIQALSFSKEDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIDRDGKVFSFGNSFFTGEIPKESPMVKREFSDPVKALKGAVKALNLPVKSENAKAKTVEGKESFEFQGTSGALSAPKAKLVYLQKEDGSLALTWKVETDVGDNWLLSYVDAHDSETVHNVVDYVASAEFKVFAWGLNDPTEGNPTSFRDPWTASSPFTWHSDGTNKYPTTRGNNAIAQDNPTGGSTYLNNYRPQSANLIFNYPWTAAMTPPSSYKDFSITQLFYTTNRYHDLLYSFGFNEAAGNFQVNNNNKGGKGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYTHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKNTNYSMGAWAANDPKGIRAYLYSTNLQTNPYMYTSVNNLREVHGIGTVWATMLYELMWGLIEAHGGTYSADPVFRNGVPQDGRHLAMKIVMDGMALQPCNPNFVQARDAIIDADRALTNGANKCTIWKAFAKRGLGYGAKYDPRTRTGSNQLPPGC

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Arthroderma otae

Length

633 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

69.377 kDa

Sequence

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Ammonium transporter MEP3

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

489 amino acids

Function

Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source. The affinity of MEP2 is about twenty times higher than that of MEP1. MEP3 has the lowest affinity.

Similarity

Belongs to the ammonia transporter channel (TC 1.A.11.2) family.

Mass

53.69 kDa

Sequence

MARGDGHLWTETYDSSTVAFMILGAALVFFMVPGLGFLYSGLARRKSALALIWVVIMATLVGILQWYFWGYSLAFSKTATNNKFIGNLDSFGFRNVYGKISDDSTYPELIYAIFQMMFMCVALSIIAGATAERGKLFPHMVFLFVFATLVYCPITYWIWAPGGWAYQWGVLDWAGGGNIEILSAVAGFVYSYFLGRRKENLLINFRPHNVSMVTLGTSILWFGWLLFNAASSLSPNMRSVYAFMNTCLSATTGGMTWCLLDYRSEKKWSTVGLCSGIICGLVAATPSSGCITLYGSLIQGIIAGVVCNFATKIKYYLKVDDSLDLLAEHGIAGVVGLIFNALFAADWVIGMDGTTKHKGGWLTHNWKQMYIQIAYIGASAGYCAVVTAIICFVLGKIPGVHLRVTEEAEALGLDEDQIGEFAYDYVEVRRDYYQWGVDTDALHTTCNGANSASETNPTEDSQNSSLSSATVSGQNEKSNNPKLHHAKEA

Protein

Ammonium transporter MEP3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Trichophyton soudanense

Length

391 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

42.98 kDa

Fragment

single

Sequence

HNVVDYVASAEYKVFAWGLNDPTEGNPTSIRDPWTDASPYTWNSDGMSKYPTTRGNNAIAQDNPTGGSTYINNYRPQSPNLIFSYPWSPTATPPSSYKDFSITQLFYTTNRYHDLLYSFGFNEAAGNFQVNNGNKGGKGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYTHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKNTNYSMGAWAANNPKGIRAYLYSTNLQTNPYMYTSVNSLREVHQIGTVWASMLYDLMWALIEAHGGTYSANPVFRNGVPQDGRHLSMKLVMDGMALQPCNPNFVQARDAILDADRALTNSANKCTIWKAFAKRGLGYGAKYDARNRTGSNK

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Extracellular metalloproteinase 3

Organism

Trichophyton violaceum

Length

391 amino acids

Function

Secreted metalloproteinase probably acting as a virulence factor.

Similarity

Belongs to the peptidase M36 family.

Mass

42.98 kDa

Fragment

single

Sequence

Protein

Extracellular metalloproteinase 3: MEP3

Gene

MEP3

Protein

Neutral protease 2 homolog MEP3

Organism

Coccidioides posadasii (strain C735)

Length

354 amino acids

Function

Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine. May be involved in virulence (By similarity).

Similarity

Belongs to the peptidase M35 family.

Mass

37.918 kDa

Sequence

MHFTSSLLALVALTTQALAFPLNDLPKRDSGLAVKLSSIGNTRVKAVITNTADHEISFLKFNTFFDSSATRKVSIAKDGSVVPFNGLYRYYNAAKLPKEAFKTLAPGASAEATFDIAETSDLSAGGSFSVFSDGMIPVADGSGTTLTGAIKYSTNELKMNVDGALAAKVQSAIPKLEKRTRIDPDCPGEYRNVLTQGLQTAAGYASRAAEAATNGDQLEEFFKTTDQQTAQNIAQRFQAIAQECGSDSQGSTTYFCDDRFNGCEQGVIAYTIPAQSVVVNCPAYWELPPVVNQGLDPDHGYVVVHEFTHATSIFSPGTQDHAYGYENCIRLSPEQCISNADNYSLYAASVSRGG

Protein

Neutral protease 2 homolog MEP3: MEP3