Protein
Mitogen-activated protein kinase kinase kinase 21
Function
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity).
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Sequence
MALPVAEGTADTPLSPARDDSGSTSSGMWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPASYVAPCGPVPPPAPPPPRPCSPVHVDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMSAAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAVLTNMPQESFHSMQEDWKLEIQQMFSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQLAEREIDVLERELNVLIFQLSQEAPHVKKRKGRFRRGRLRLKDGHRISLPSDFQHKITVQASPTLDKRRSSDSGLCSPPGSPLMLPRLRAIQLTSDENNKTRGRNMVFRQEDFEDVKRSFKKKGCTWGPSSVQTKERPEGRERVRPLSDGNSPWSSLLIKSQKTTPLASLFVDQPGSCEEQKLVPEGLEHRKPKQTKFPGQAHVGLPLCKDSQREDSSEAESREEGSPKGSPVNNVGAPMLRKKTESALCECGMLLASMALGLDVRKLHGAQAPAKPSPKMEKKEEGALQPASRCQSSPSSLLRQPSAGRAPSGGSTLLLPSAPSHSSKSSLSMKCLLQAGKEESSLGNARDLCGPTTLTPDPGSAAPESGCELIPGLRPKTDYGVLRSMPHAILEQTGERLPGCAIVGDKGCHHMQMGSEETPLWLQSAPEDSGLPHSPSPGPQRDLASQASLVKPEGVLGECQACPALPQRPHTASVRTTSPPTWVCDKDHQVPALACLLGAQERSRCQTPSLLDASIEGQKKDCAMPLCRVKSVMCQPSIYALEKDFLT