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MAGI3

Gene
MAGI3
Protein
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Organism
Homo sapiens
Length
1481 amino acids
Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Similarity
Belongs to the MAGUK family.
Mass
162.949 kDa
Sequence
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSHGHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSKGENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKRMVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVVSNKTEDHKGKELEAADKNKETGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGMAEKRQ

Gene
Magi3
Protein
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Organism
Mus musculus
Length
1476 amino acids
Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Similarity
Belongs to the MAGUK family.
Mass
161.672 kDa
Sequence
MSKTLKKKKHWLSKVQECAVSWAGPPGDLGAEIRGGAERGEFPYLGRLRDEAGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGSMETREMHSETSDCWMKTVPSYNQTNSSMDFRNYMMRDENLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQAEIHSAKTDVERAHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNTQDFKLGAMVLDQNGKSGQILASDRLNGPSESSEQRASLASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKTKTDTKENSGSLETINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESHQAFSQNGSPRLNRAELPTRSAPQEAYDVTLQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGSPADRCGGLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSPALQHRPMGQAQANHIPGDRIALEGEIGRDVCSSYRHSWSDHKHLAQPDTAVISVVGSRHNQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDTNSPSSSNVIYDEQPPPLPSSHSASTFEESHVPATEDSLTRVQICEKAEELKDTVQEKKSTLNGSQPEMKYQSVHKTMSKKDPPRGSGHGEKSRLKGENGVTRRGRSASPKKSVNRHSEEHLEKIPRPLKSDPKEKSRDRSLSPRKGESKGRLTIKAGSGQDPYRKDRGRSSSPKKQQKIGGNSLSNTEGKLSEAGSRRAAGHPRDSTEQLPDGREKSGVSRKDLKQSQPGKTRTKSPEKKSSKVDETSLPSKKTSSTAGRVVSEKEKGKKPTAGETSRETVEHTQISAKQLKQEAQEKTALGNADDHKGRESEVTDRCRERAGCTPQSSSLVKKAPITPGPWRVPRANKVTGTTGMADKQL

Gene
Magi3
Protein
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Organism
Rattus norvegicus
Length
1470 amino acids
Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Similarity
Belongs to the MAGUK family.
Mass
160.563 kDa
Sequence
MSKTLKKKKHWLSKVQECAVSWAGPPGDLGAEIRGGAERGEFPYLGRLRDEPGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLITIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGSMETREMHSESSDCWMKTVPSYNQTNRSMDFRNYMMRDENLEPLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQIGQAETHSAKTDVERAHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKMAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYALPDDSEDPVVDIVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKSGKLLSSDRLNGPSDSNEQRASLASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDTKETSGSLETINEPTPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESPQAFSQSGSPRLNRTELPTRSAPQESYDVILQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGSPADRCGRLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSPALQHRPMGQAQATHIPGDRTALEGEVGKDVCSSYRHSWSDHKHLAQPDTAVISVVGSRHSQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDIYSPSSSNVIYDEQPPPLPSSHSAATFEESHVPVTEDSLIRVQTCEKAEELKDTVQEKKSTLNGSQPEMKYQSIQKNVSKKDPSRSHGHGDKNLLKGENGVTRRGRSASPKKSVNRHSEEHLEKIPRPLRSDPKGKSRDRSLSPRKGENKGQVTIKAGSGQDPCRKDRGRSSSPRKQQKIGGNSLSNTEGKLSEAGSRRAAGLSSDSPEQLPEGKEKSGVSRKDLKLSQLGKNRTRSPEKRSSKVDEASLPSKKTSDTASRVVSEKEKGRKPGTGERSRDKTGESVQTSAKPLTQEAGEKMALSKASEVTDRGKERAGGAPESSSPVKKAPITPGPWRVPRANKVTGTAGMADKQL

Gene
MAGI3
Protein
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Organism
Gallus gallus
Length
1128 amino acids
Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes.
Similarity
Belongs to the MAGUK family.
Mass
122.702 kDa
Sequence
MSKTLRKKRHWLSKVQECVVSWGGPAGPDPELLHGGAERGEFPYLAGRLPTGAEGAPGPALLSGKAPAPGDVLLEVNGTPVSGLTHRDTLAVIRHFREPVRLKTVRPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFIPVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNDFDTESQRKRTTSVSKMQRMDSSLPEDEEEEEKEAVNGSGGIENKEKHSDSSDWMKPVPSYNQTSSSMDFRNYMSRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHINQKTQFENPVLEAKRKKQLGQTDGGPSKSVPEKSLFTRDPSQLIGALIRTSLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGRIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNMTLCRGYPLPDDNEDPVVDIVTATPIINGPPVTKGDICLTSQELIAGTVVLDQNGKTGPMLVNGRLNGPSMDTNEQRISVASSGGSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDVIKEICHQNVQSLTHLQVVEVLKQFPIGAEVPLLILRGGPPSPTKTGKMKDKQESSGSLEALSDAIPQPMPFPPTAVRSGSPKLDPSEVYLKSKTMYEDKPPNTRDLDVFLRKQESGFGFRVLGGDGADQPIYIGAIIPLGAAEKDGRLRAADELMCIDGVPVKGKSHKQVLDLMTSAARNGQVLLTVRRKIFFGGEKQAEEDESQAVVTQNSSPRLNRAEFATQQSPEVYDVCLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIDGSPADQCGKLKVGDRISAVNGQSIVELSHDSIVQLIKDAGHVVTLTVVAEEEHRGPPSGTNSAKQSPAPQHRPLGPAQSSASSTDRGATEGEAGKEVSNSYRLSWPEHKHLAQPDAGSASGVGSRHSQAQNSGCFPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAVKDGRVHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHSLAPSSLCPYVKPEQH

Gene
magi3
Protein
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Organism
Xenopus tropicalis
Length
1107 amino acids
Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes.
Similarity
Belongs to the MAGUK family.
Mass
121.84 kDa
Sequence
MSKTLKKKKHWLSKVQECGLSGVGGDPCSLLEIRGGAEHGEFPYLGRQREDVASFIVGKVPSQGDVLLEVNGTPVSGLTHRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRSPRDGEVPGVDYNFISVEQFKALEDSGVLLESGTYDGNFYGTPKPPAEPNPFQADPVDQVLFDGEFDTETQRKRTTSVSKMQRTDSSLPEEEDEEEREAVNGSSGSTDHRDRQEPSEWGKTVPSYNQTNSSMDFRNYLTRDENLEPLPKNWEMAYTEAGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHINQKTQFDNPVLEAKRKKQLNPAPSEGTVHQEPENSQFTRDPSQLKGALLHTSLKKSAMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGTCVLGHTHAEVVQMFQLIPINQYVNMTLCRGYPLPEDSDDPVADIVNTVPPIINGQMLTQGDINMGSQELKSGVIDLDQRGKPGLMVVNGRLNGPSLDIQDQRTSMASSGNSLPELVTIPLLKGPKGFGFAIADSPMGQKVKMILDSQWCPGLQKGDVIKEICHQNVQNLTHIQVVEVLKQFPVGAEVPLLILRGGPPSPSKVTKVKSDKQELMGSIEAIAPGEPLPQPLPFPPNLARSCSPKLDPSEVYKKSKNIFEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQAIYIGAIIPLGAAEKDGRLRAADELICIDGVPVKGKSHKQVLDLMTNAARNGHVLLTVRRQIYYTDKQQEEEELQHTPPAHNGSPRLNRIEVSAIPKLPAEAYDVILQRKDNEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCRKLKVGDRISAVNGQSIVELSHDNIVQLIKDAGNTVTLTVIAEEEHRGPPSGSNSARQSPAPQHRPMGQTQPTYGTLDRYSWSDHKADCGPALPAGSWQALSVGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINNEPTQGITHTRAIELIQAGGSKVLLLLRPGTGLIPDYSLAPSSLCSYVKPDQQ