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MAFB

Gene
mafb
Protein
Transcription factor MafB
Organism
Danio rerio
Length
356 amino acids
Function
May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain.
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
40.233 kDa
Sequence
MSADLAMGPELPTSPLALEYVNDFDLMKFEVKKEAMAAHDRANIRQCNRLQPQGSVSSTPISTPCSSVPSSPSFSPTEQKNHLEELYWMPSGAYPQQIDPQTLSLTPEDAVEALIGATAHGHPPPPHVQQQLQAGAFDGYRGAHHHHGHAQQQQQQQPQHHHHQHQYGAIPHHPDDLSGHPGAHGHHPHHHHHHHHSQDPDSPSPTSPEQLHHRHHHHHHPHGHPGQQGHHGVGGGLNVEDRFSDDQLVTMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRFKRVQQKHLLENEKTQLINQVEQLKQEINRLARERDAYKLKCEKLTGANGFREAGSTSDNPSSPEFFM

Gene
MAFB
Protein
Transcription factor MafB
Organism
Homo sapiens
Length
323 amino acids
Function
Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
35.792 kDa
Sequence
MAAELSMGPELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEQKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDSFRGAHHHHHHHHPHPHHAYPGAGVAHDELGPHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATASATAAGGNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL

Gene
MAFB
Protein
Transcription factor MafB
Organism
Macaca fascicularis
Length
323 amino acids
Function
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (By similarity).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
35.78 kDa
Sequence
MAAELSMGPELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSLSSTPLSTPCSSVPSSPSFSPTEQKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDSFRGAHHHHHHHHPHPHHAYPGAGVAHDELGPHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATASATAAGGNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAHKVKCEKLANSGFREAGSTSDSPSSPEFFL

Gene
Mafb
Protein
Transcription factor MafB
Organism
Mus musculus
Length
323 amino acids
Function
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
35.809 kDa
Sequence
MAAELSMGQELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEPKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDGFRSAHHHHHHHHPHPHHGYPGAGVTHDDLGQHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATAAATAAGGNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL

Gene
Mafb
Protein
Transcription factor MafB
Organism
Rattus norvegicus
Length
323 amino acids
Function
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (By similarity).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
35.792 kDa
Sequence
MAAELSMGPELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEQKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDGFRSAHHHHHHHHPHPHHGYPGAGVTHDELGPHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHAAAAATAAGSNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL

Gene
mafb
Protein
Transcription factor MafB
Organism
Xenopus tropicalis
Length
316 amino acids
Function
Acts as a transcriptional activator or repressor. Implicated in the regulation of cell-type specific gene expression and play a role in inductive events during lens development (By similarity).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
36.311 kDa
Sequence
MAGELSIATELPTSPLAMEYVNDFDLMKFDVKKEPLGGRPDRAIRPCNRLQPTGSVSSTPISTPCSSVPSSPSFSPTEQKTHMDELYWMTNSYQQVNPEALNLTPEDAVEALIGPHQMPPQMQGYDSFRGHHHHHHNNHHHQNHHQYQGLPHEEMGLPHQHPHHHHHHHHHQPSPSPSGSSSSSQQLQNSHQQHQNSSAVEDRFSDDQLVSMSVRELNRHLRGFTKDDVIRLKQKRRTLKNRGYAQSCRFKRVQQKHHLENEKTQLIQQVEQLKLEVSRLARERDAYKIKCEKLANTTFREAGSTSDNPSSPEFFM

Gene
mafb
Protein
Transcription factor MafB
Organism
Xenopus laevis
Length
313 amino acids
Function
Acts as a transcriptional activator or repressor. Implicated in the regulation of cell-type specific gene expression and play a role in inductive events during lens development.
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
35.749 kDa
Sequence
MAGELPIATPLPTSPLAMEYLNDFDLMKFDVKKEPLGGRPDRAIRQCNRLQPTGSVSSTPISTPCSSVPSSPSFSPTEHKTHLDDLYWMSSSSYQHVSPEALNLTPEDAVEALIGQHQMPPQLQGYESFRAHHHHHHQNQHQYQGVHHEEMGLPHHHPHHHQHQHHQTSPSPSGSSSSSQQLHHQQQHSSSSAVEDRFSDDQLVSMTVRELNRHLRGFTKDDVIRLKQKRRTLKNRGYAQSCRYKRVQQKHNLEGEKTQLVQQVEQLKQEVSRLARERDAYKIKCEKLANNNSSNFREAGSTSDNPSSPEFFM

Gene
MAFB
Protein
Transcription factor MafB
Organism
Gallus gallus
Length
311 amino acids
Function
Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha-A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
35.467 kDa
Sequence
MAGELSIGAELPTSPLAMEYVNDFDLMKFDVKKEPLGRNDRSGRHCTRLQPAGSVSSTPISTPCSSVPSSPSFSPTEQKTHLEDLYWMANSYQQMNPEALNLTPEDAVEALIGSHQVSQQLQGFESFRAHHHHHHHHHQHHHQYPAVTHEDLAGSGHPHHHHHHHHQASPTPSTSSSSSQQLQTSHQQHPPSSSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVTRLARERDAYKLKCEKLASNGFREAGSTSDNPSSPEFFM

Gene
MAFB
Protein
Transcription factor MafB
Organism
Coturnix japonica
Length
311 amino acids
Function
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Binds DNA via its basic region-leucine zipper domain.
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
35.476 kDa
Sequence
MAGELSIGAELPTSPLAMEYVNDFDLMKFDVKKEPLGRNDRSGRHCTRLQPAGSVSSTPISTPCSSVPSSPSFSPTEQKTHLEDLYWMANSYQQMNPEALNLTPEDAVEALIGSHQVSQQLQGFESFRAHHHHHHHHQHHHHQYPAVTHEDLAGSGHPHHHHHHHHHASPTPSTSSSSSQQLQTSHQQHPPSSSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVTRLARERDAYKLKCEKLASNGFREAGSTSDNPSSPEFFM