MAD1

Spindle assembly checkpoint component MAD1

749 amino acids

Central component of the spindle assembly checkpoint. Thought to recruit MAD2 to unattached kinetochores. During checkpoint activity, MAD2 is relayed from the MAD1-MAD2 complex to the mitotic checkpoint complex (MCC). The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.

Belongs to the MAD1 family.

87.651 kDa

MDVRAALQCFFSALSGRFTGKKLGLEIYSIQYKMSNSGGSSPFLESPGGSPDVGSTNGQSNRQIQALQFKLNTLQNEYEIEKLQLQKQTNILEKKYKATIDELEKALNDTKYLYESNDKLEQELKSLKERSANSMNDKDKCIEELRTTLQNKDLEMETLRQQYDSKLSKVTNQCDHFKLEAESSHSLLMKYEKEIKRQSVDIKDLQHQVMEKDDELSSVKASKMINSHPNYSTEEFNELTEMNKMIQDQVQYTKELELANMQQANELKKLKQSQDTSTFWKLENEKLQNKLSQLHVLESQYENLQLENIDLKSKLTKWEIYNDSDDDDDNNVNNNDNNNNNKNDNNNDNNNDTSNNNNINNNNRTKNNIRNNPEEIIRDWKLTKKECLILTDMNDKLRLDNNNLKLLNDEMALERNQILDLNKNYENNIVNLKRLNHELEQQKSLSFEECRLLREQLDGLYSAQNNALLEVENSETHASNKNVNEDMNNLIDTYKNKTEDLTNELKKLNDQLLSNSNDVETQRKKRKLTSDQIGLNYSQRLNELQLENVSVSRELSKAQTTIQLLQEKLEKLTKLKEKKIRILQLRDGPFIKDQFIKKNKLLLLEKENADLLNELKKNNPAVETVPISVYDSLNFELKQFEQEVFKSNKRFSRLKQVFNNKSLEFIDVVNSLLGFKLEFQQDSRVKIFSCFKPEKYLIADLNENTLKSNLDADIEGWDDLMNLWVEDRGQLPCFLATITLRLWEQRQAK

MAD1

Mitotic spindle checkpoint protein MAD1

726 amino acids

Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. Required for anchoring MAD2 to the nuclear envelope.

Belongs to the MAD1 family.

82.433 kDa

MILRTPQPKRLRSDAGESPFPTGATGSGNQLIIYEDSPLPAPAPLQTSHDHSADQHLCTYQCRQMVKADVLDALSTAEKQVEESKTKLQTLNANFTEADAERKHFRDKFLYSEQELAAAKAREKMLQEQLLMEINNSQERYTKELQSCHELEVKLQNEMNLRKKAESSAATAEEKAKLLEDKLTQLSGSVDREKKRLNNDIAQLGKEAKLSVARIGADLERMQCRAQNAETESNLLRSQLEHLKLIFDECLQEKTEVDKKLSSFTSEAASSSDNSVLVKHLQEELKRYEAEVREARKLKSRHLDAELLNVNLLEEQSRRERAESELSKFHDLQLSMEKLENELSSWKSLLNDIPGVSCPDDIVMRFSVLQNEVVQSTMKIGEASTRIKQLEETLEAIQLGRQNAVSEAALAKEKSEALKTDVKRIEVMLTLVTEEKEQLKAVVNELRKSNSEGSVSGAADGALIQGFESSLAKKENYIKDLEQDLNQLKDVNNRQRTEIELLNEKLVDEARRNKSLERDSDRLRSEISLLESKLGHGDYSAANTRVLRMVNTLGVENEAKQTIEALQAELQKTKERLQAVEELKSQSGDAGKLVDSHITGKIAQLKEQNATLEKREERYKTVFADRISVFRRACCELFGYKIVMDEHQRPNGIPVTRFTLQSIYAQSDDEKLEFEYESGNTSILNNEYASQGDIAKQIEIFIRKFNSIPAFTANLTMESFNRRTLY

MAD1

Spindle assembly checkpoint component MAD1

704 amino acids

Central component of the spindle assembly checkpoint.

Belongs to the MAD1 family.

79.963 kDa

MSDTPSSPFIEHPETPRKALFSSNRPSPVRSTHATPSLHGTPSTASRFSRTPREDVIGLKKTISQLRYDLEALKQEQQVAQILQEEKERELEAKHKKELDRAEQAESDQVFLFNKQKELSDENRTLKEELRSLQSQHEADGRELNHELEGLKDLLNDLQSENRALVSEMNYKIEDYEHRIKAASTTTDDLLKEVENRGTALTEAKMNVVKFEQLVESLKGESLDLKQSAKDLEAVEQTKSQLSDQIKYSRELEAKVSALTVRVEAAESAQQLSQVYEEDLSSMKGKLKNMEGLRQQLAEQQLQILVHEENSAKWKAYLEKSDEFKTVEEVVTALNKARMEKASLLERAGSGVNDETRSTAEAYARLQERVTTLESELQLAQNQLKTEKKKVATSIRQHTLAANEAKFLREQLKAYDDEEVTAAGADVKQGRIDELEKLLEAVKNEKSVLEGELKEARSEQGCTVAAGTKRPRADDSVSSEVISEYTRKLQTLQQEFDEVSVEARLLAKTKEALEARLESLEKSQESRVRILELRENPTSRHEAVKQSMLDTLKAENEALMGKNENSKSVPQASLERKQLELQGVRDKLASTEKSYQRLKEVFSVKSLEFREAVYALTGYQIDILRNKKVKVTSMYAQSDEDSFTFLPDPNHKGQFAGVIDSPLTDEFSNIVDYWVKDKKDFPCFLAALNLELYERKENNGNQAS

MAD1

Spindle assembly checkpoint component MAD1

696 amino acids

Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.

Belongs to the MAD1 family.

82.221 kDa

MSTGSSPFVDHKSNNSTISINNNSSILNESSISKAYVSKLEFQLDTIKTENRILQQEKDQITSDYRKIIDEKNQELENLKLNFKYVYDEKNQLESKLTNQEQVSTNNINQLSDEIQTYKRENLKLTKDYNSLLDKFNKLNRKNQQIMHDLNKEIEVNDKLHQELKIKEKTNQELQKASDTAINELEQYSKILDKKNGSDNLLYKNLTTKSNNLQNINHQLQNKIDQLLQNKTSNELLKQQNQSLLHKLQNLENIESKYLQLEIEKLQLETKYNDLFKALDTAIASSNEYKDNENTDDTIHTSKVKSFIEYCNNLQAKNLTLQEKYDSKIIQVKELTKELEDHAREIETDFLPTITDLESKLKVYADQNTKLERTKSLREKEITFLRNSLKQMEQIHANQQHKQQEQEKEENTENKSISQYMTNLEKLVDEYKTKIDELEKKNLEYNKSSIITNEKTPSNKRQRLESNYTFKTQAIELEKENIEISSKLKQAESTIEQLKFKISELDKVETRKEQYRILQLKNNLISQDQFIKQTTLIALRKENEELINKYIKNLPIEEQIPKGVFQRQEDDKQRLQAQIDHLTKRSTRLREVFTKKSKDIITVIAKYFGFIIEFLPNPINPTDLFSRIKLRSRYIPSEEDCYLIIDVENRGLKAHGNFQFKQICEELAQYWVNENNQFPCLLSAVNLKLYEIYASK

mad1

Spindle assembly checkpoint component mad1

689 amino acids

Central component of the spindle assembly checkpoint. Has a role in the correct positioning of the septum. Required for anchoring mad2 to the nuclear periphery.

Belongs to the MAD1 family.

79.89 kDa

MSSKLTVYQATTSMADSPRDPFQSRSQLPRFLATSVKKPNLKKPSVNSANETKNPKLASLEFQLENLKNDLKRKELEFEREQIELQRKLAEEHEQKNSLQLRLTLVEKQLEEQSTSYQKEIEEVRNEKEATQVKIHELLDAKWKEIAELKTQIEKNDQALSEKNHEVMVSNQALQMKDTNLTNLEKLFADSREQLETKCKELAAAEQQLQELSVHNQQLEESIKQVSSSIELEKINAEQRLQISELEKLKAAQEERIEKLSSNNRNVEILKEEKNDLESKLYRFEEYRDKVATLELENEKIQTELNSWKSLITNELPTPEAVSNKLVFLQNTNANLGERVSSLESQLSNKPANQPLGANEKDAAHITELETKLKELHEQNRRLQRQKSLATQEIDLLRENLKSYDDEEAILSEKNTDMKKLERIEGLVKLVDEYKLKLESMPVSLDVDETSDEVSLQKRRRKNEHKDAGYVTELYRKNQHLLFQVKEKTNIEAFLREQIITLESSIATLRQELAQVTEINSCRVLQHRSNPTLKYERIKAAQLEMLNAENSALKALLEDKKVDCLPIQSFKIAERKALDLKKEVAEREKRIQRLKEIFSVKSLEFREAVFSLFGYKLDFMPNGSVRVTSTYSREDNTAFIFDGESSTMKLVGNPSGPEFERLIRFWCDERKTIPGMLAALTLELLDKND

MAD1

Spindle assembly checkpoint component MAD1

674 amino acids

Central component of the spindle assembly checkpoint.

Belongs to the MAD1 family.

79.989 kDa

MDSDSGGSSPFVESPHGEEVQVRGDETNNTYGQDQWKFKYEGLLNEWEIQKIQWQKEKYEFEKRQLAAEDRLRNANDEMDILIQRNQDLVYRIEEEERNRINNDEGNDLKGGAGSMDKGKKQEIEELSRRYEADRFEWKTQNEELDLELKSCKSLISKYEQLLMEQSEKINSLRSEVKNKEDQIAELEVVRQKKDHNITNTEEFRNLTTLKDIIKTHDQYALDLEQSNMRQAEELKRLKSLKESATFWRSENEQLQERIRQLEEVEQQYNEVQLEILELKVNISEWDRFLKEKCQPGDTETAEYTPSDFVRDYEILQNDYKVLNDEFEDLKKETQMVKILNDELAMERNQILNLKNEYEKSIINLEKLNYELEQQKTLSFEECKLLRKQLESIKHKSNHEENDSTKDYEVLIDNYKNQTKDLTSELKRMNDELIGSNRDSSAGSKKRKLRTGDSVNVNLAQKLNTMQIENSNLQKEIHKLKAIIDVLEKKIRLLKENKEKRIRILQQRDSPLLKIQFARKQELDLLKDENKELLSLIENVTENNQNRIDTIPLSAYKSLEFQYQQSQENVVKGEKQLSRLKQIYNKKSLEFIDIVNSMLGFRLEFMLDGRVKIYSCYKPDKYLIANLIDNTLKSNLDAIISDWDELLSLWVVERGQLPCFLATITLRLWELNPI

MAD1

Spindle assembly checkpoint component MAD1

669 amino acids

Central component of the spindle assembly checkpoint.

Belongs to the MAD1 family.

78.158 kDa

MSDTASSPFIDRPRSMLDEDSEFNSRQLISNLQFQISSLKTEKSLLQQNKESMAEKYEALLITKNEEVVSLQNDFDYVFKQRDELQSKYDNSQQINGKTVESLQVQLKDITERYDELKEEHEYLNSDFKKFCRDNNQVKSDLEFHINSKDQMNEKITSLQDENKSLCKTNDELIEKLNSISEQLVSNTQDKFSRNLQEQNSKLQRTNNQLQLKVDSLLQHRTSVELLRQKNITLTNKLSSLANLEEKCCKLEIENLELSNKFDTFFKTIEDSVNDDTSRTNESVVIEFMNKYKRLQNLNLVLQDKYNQSVTGVKNMQTELSNMQQKYSEAISKVESLNETVSTKTEFIDKLERQKLLNVKEIEYLRDSLKKLEELNLKRSKEETNDKSTEQYMTNLEKLVDEYRTEINTLQKQMSSQEIQSNVQSGSKRPRIIDNGIQNDFKSQVSVLEKENLKLLSTIKNLEYNNKTLGEKLQNLESLDNKKKELHILQLKSNPASQDQLIKQQTLDLLSKENQEMIETFVKNKSAHDMIPKSLFERQENDKLQLQTKIDQLNKRISRLRDIYSQKSRDILSVISKFFGYTIEFLPSPINSNDLSSRIKLVSKYMNNKDESNSAYLILDVNSKSLKANGSLEFKTLCEDLVTNWIREKDQIPCFLSALNLSIYDKYVS

MAD1

Spindle assembly checkpoint component MAD1

659 amino acids

Central component of the spindle assembly checkpoint.

Belongs to the MAD1 family.

75.421 kDa

MSQTGDSSSFVEEPASPEARQRELERQVLGLEYRLRTEHSEAEMARLALERELAGMQGKYKQCMGELEAALADTRYLYEQNAALEARARAADEDAGGAAAAERAAAAEERARAAEARARELEEALQAARGEAAAAGRAAAGAAAGAAAAEQSGLLRKYEAEIERQMGELRALAERLAEREDEVAGLKAQRVLQAHRSYSAEEVEELGVLRRTLQEQLALSKELERANLEQANELKRLRQRSESQQFLQLENSKLRARLEKTDALRQQLDDLQLENVQLQEKLTKWEVYQADGSSPENVLHEMALAKQERLALVEQVGKLQLDLNNMKILNDELALERNQLLDLNKKYESSILNLKKLNYEIEQQKLLSFEECKLLRQQLDDLSEVDKDHTPDTRDRKKIQTLVDTYKNQTEDLTNELKKLNEQLLERSDLDGNPRKRRKASDDLAFNYSQRLNELQLRNKDLERRLANSDENASLLEEKLRKLQSLNEKKIRILQLRNNPLLKDQFVKQKQLTLLKQENLELAQQLDAQQGLEAVPRSVYERQQYDIQLLEDELFSINKRTTRLKEMFNRKSLEFIDAVNSLLGFKLEFQVGGKVKMIPCFKTDRYLIADLQTNTLKSNLDKVMPEWDAMLAEYVGKRQQLPCFLAKIMLLLAESSSSQ

MAD1

Spindle assembly checkpoint component MAD1

657 amino acids

Central component of the spindle assembly checkpoint.

Belongs to the MAD1 family.

78.157 kDa

MNNSGSGGSSPFVESPDLVSDGHLHTERKDTPIDVDNWKYKYDNLLNQYEIEKVRWQKEQYDSEKSHEALHLQLEKARNEIDQLVESKRFLEAQLQSQHPQNTQKEWSHEDNKVNNNSMNNDYMLLEEKYKSDVFHLDNSVNELKLELTSCRSLLKKYEEVIEQQSEQIKEIKKTLKKKEQELDEIEVNRLKQAHNATNTEEIRQQTNENASFSNGYNTLMSMKNSVNYWKNENQQLNQKLSEYSDIYQQLQEAQLEIMELKANLEEWNKFLSNKKQQDNSNDYSIDHFIIEFESQRRELNMVTEELAEVKKSYYNSKILNDELALERNQLLKLKDDYENNIINLEKLNHELEQQKVLLEEECSLLKNQIPTKENLNQQIRSTNRNDAEYDSLLDNYKQETENLTNELKRLNDSLIEQNRNQGTEMKKRKLRNGDHININYSQRLNELQQNNLSLEKDNEKLRLVVEKLEGKLDDLRKTKPKNIRILQQRDSPLLKLQFVRRKENELLREENQNLLTMIENITENRNESFDKIPLTSYNSLKYQYEISMDTNKKQEKKFSRLKQIFNKKSLEFIDVVNSLLGFKLEFQQDGRVKIYSCYMPNKYLIANLVDNTLKSNLDTVISDWDSLLNDWVVEKGQLPCFLASLTLQLWKMENDS

MAD1

Spindle assembly checkpoint component MAD1

648 amino acids

Central component of the spindle assembly checkpoint.

Belongs to the MAD1 family.

76.063 kDa

MSLTPQIKEKPLESLDADQLRRRVLTLQYKYTTLQNEYEISKLSSERETYSLQNKYDKSMNELENALKDTKILYEENIKLKEELKSKDALPKEDEKIITTLRTQVVSLKNEVNLKEQRIVELAHKLSSKQNEVTNAIESMKLEIEGSGNILHQHETQINKHVEEIRYLQQELKEKENLISELRSVQTSASHRNNSTEELQDLAVLNKTLKEQLNYAKELEDMNLKQATELKKLRQNNDVQSLLKKENELLQSKLDQLNSLQKKFESLEMENISLQEKITQWGIVRLDGKFKNPNDVITELNMLQRENTFLLDTNSKLQIDFNQMSMLNDEMAIERNQLLDLNKDYETSILNLKRLNHELEQQKLLSFEECKLLRQQLEEFEEQDDKKKTPGDQVNASNIIEGYKNQTEDLTNELKRLNEELSKTDDKIQKRRKITNDLGISYSQRLNELILENKKLERLLSATKNHANILEQKILDLTSLKEKKVRILQLRDNPLLKEHYIRKEKLALLEKENSDLLSGIETDAIPRSVYDRIKHDMKLLEKEIFSANKKTTRLKEVFNKKSLEFIEAVNSLLGFKLEFLAHGKVKLVSCYQPNKYIIADLQSNTLKSDLDKVIPEWETLFQLYVIEKGELPAFLSQVKLRLWELSQP