lys2

L-2-aminoadipate reductase large subunit

1409 amino acids

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Belongs to the ATP-dependent AMP-binding enzyme family.

154.842 kDa

MAVGTASLQDRLETWAQRLKNLTVSPLTRDYPDTQKTDSKRVIEAFESLQLPKAKLTGSSSSFIAFLTAFIILVARLTGDEDIAVGTNSNEDGRAFVIRVPIDTSESFAQLYAKVDKAYKEGSSQIVPLGSLRSYIQEKSKSERTPVLFRFAAYDAPASSQDYPANTFDTTDLVVNVAPGSAEVELGAYYNQRLFSSARIAFILKQLASIASNAAANPDEAIGRIDLMTEDQRALLPDPTCNLNWSNFRGAIHDIFTANAERHPEKLCVVETQSSSSPHREFTYRQINEASNILGHHLVRSGIQRGEVVMVYAYRGVDLVVAVMGILKAGATFSVIDPAYPPERQNIYLDVARPRALVNIAKATKDAGELSDIVRTFIDENLELRTEIPALALLDDGTLAGGSINGQDVFANDVALKSKPTGVVVGPDSIPTLSFTSGSEGRPKGVRGRHFSLAYYFPWMSETFKLTPDEKFTMLSGIAHDPIQRDIFTPLFLGAQLLVPAREDIQNEKLAEWIEKYGATITHLTPAMGQILVGGASAQFPALHHAFFVGDILIKRDCRSLQGLAPNVSIVNMYGTTETQRAVSYYEIPSYASNEGYLNNMKDVIMAGRGMLDVQMLVVNRYDPTRLCAIGEVGEIYVRAGGLAEGYLGSPELSAKKFLNNWFVNPEIWAEKDQAESRNEPWRQFYVGPRDRLYRSGDLGRYTPSGDVECSGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVRRDKDEEPTLVSYFVPDMNKWASWLESKGLKDDDSDSEGMVGLLRRFRPLRDDAREHLRTKLPTYAVPTVIIPLKRMPLNPNGKIDKPALPFPDTAELSAAAPRRASSALQALSETEQTLAQVWAKLIPNVTSRMIGPDDSFFDLGGHSILAQQMFFELRRKWRVIDISMNAIFRSPTLKGFASEIDRLLAMESFATSDDKTLAVQAANEPDDEYSKDAVQLVNELPKTFPQRTEAMLTSEPTVFLTGATGFLGAHILRDLLTRKSPSTKVVALVRAKTEELALERLRSTCRAYGFWDEAWTAKLQAVCGDLGKPQFGLSQSVWDDLTNRVDAVIHNGALVHWVYPYATLRPANVMGTIDALKLCASGKAKQFAFVSSTSALDKDRYVQESERIIAAGGNGISEDDDMEGSRVGLGTGYGQSKWAGEYLVKEAGRRGLRGTIVRSGYVLGDSVTGTTNTDDFLIRMLKGCIQIGLRPNIFNTVNMVPVDHVARIVIATAFHPPATGVNVAHVTGHPRLRFNQFLGALELYGYNVPQVDYVPWSTSLEQYVNDGEHNDKESQHALMPLYHFVTSDLPSNTKAPELDDVNAATALRADATWSGVDASAGAGVTEELVGLYASYLVQTGFLPAPTVAGARPLPAAQISEEQKKTLLSVGGRGGTS

LYS2

L-2-aminoadipate reductase

1392 amino acids

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Belongs to the ATP-dependent AMP-binding enzyme family.

155.346 kDa

MTNEKVWIEKLDNPTLSVLPHDFLRPQQEPYTKQATYSLQLPQLDVPHDSFSNKYAVALSVWAALIYRVTGDDDIVLYIANNKILRFNIQPTWSFNELYSTINNELNKLNSIEANFSFDELAEKIQSCQDLERTPQLFRLAFLENQDFKLDEFKHHLVDFALNLDTSNNAHVLNLIYNSLLYSNERVTIVADQFTQYLTAALSDPSNCITKISLITASSKDSLPDPTKNLGWCDFVGCIHDIFQDNAEAFPERTCVVETPTLNSDKSRSFTYRDINRTSNIVAHYLIKTGIKRGDVVMIYSSRGVDLMVCVMGVLKAGATFSVIDPAYPPARQTIYLGVAKPRGLIVIRAAGQLDQLVEDYINDELEIVSRINSIAIQENGTIEGGKLDNGEDVLAPYDHYKDTRTGVVVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFNWMSKRFNLTENDKFTMLSGIAHDPIQRDMFTPLFLGAQLYVPTQDDIGTPGRLAEWMSKYGCTVTHLTPAMGQLLTAQATTPFPKLHHAFFVGDILTKRDCLRLQTLAENCRIVNMYGTTETQRAVSYFEVKSKNDDPNFLKKLKDVMPAGKGMLNVQLLVVNRNDRTQICGIGEIGEIYVRAGGLAEGYRGLPELNKEKFVNNWFVEKDHWNYLDKDNGEPWRQFWLGPRDRLYRTGDLGRYLPNGDCECCGRADDQVKIRGFRIELGEIDTHISQHPLVRENITLVRKNADNEPTLITFMVPRFDKPDDLSKFQSDVPKEVETDPIVKGLIGYHLLSKDIRTFLKKRLASYAMPSLIVVMDKLPLNPNGKVDKPKLQFPTPKQLNLVAENTVSETDDSQFTNVEREVRDLWLSILPTKPASVSPDDSFFDLGGHSILATKMIFTLKKKLQVDLPLGTIFKYPTIKAFAAEIDRIKSSGGSSQGEVVENVTANYAEDAKKLVETLPSSYPSREYFVEPNSAEGKTTINVFVTGVTGFLGSYILADLLGRSPKNYSFKVFAHVRAKDEEAAFARLQKAGITYGTWNEKFASNIKVVLGDLSKSQFGLSDEKWMDLANTVDIIIHNGALVHWVYPYAKLRDPNVISTINVMSLAAVGKPKFFDFVSSTSTLDTEYYFNLSDKLVSEGKPGILESDDLMNSASGLTGGYGQSKWAAEYIIRRAGERGLRGCIVRPGYVTGASANGSSNTDDFLLRFLKGSVQLGKIPDIENSVNMVPVDHVARVVVATSLNPPKENELAVAQVTGHPRILFKDYLYTLHDYGYDVEIESYSKWKKSLEASVIDRNEENALYPLLHMVLDNLPESTKAPELDDRNAVASLKKDTAWTGVDWSNGIGVTPEEVGIYIAFLNKVGFLPPPTHNDKLPLPSIELTQAQISLVASGAGARGSSAAA

LYS2

L-2-aminoadipate reductase large subunit

1391 amino acids

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Belongs to the ATP-dependent AMP-binding enzyme family.

154.741 kDa

MTDFWLNYLDNPTLSVLPHDFLKPANNKSVEGTYTFNIDNGSTDFKFGLAVFAALVYRLTGDEDIVIATDESANTPEFIVRLNLTPELTFQELVSKITKEYENNISQINYKALSEVSHRIKEAKGLDENPGLFRLSYQHAHSNQQLNTTVEGSIRDLAIYTDGTKFTIYYNALLYSHERVVICGEQFAQLTTVSGDTDTVIAEVFLITDFHKKNLPDPTIDLDWSGYRGAIQEIFMDNANKHPDRTCVVETVSFLESNSKTRNFSYHKLIKLLIVVGNYLKETGIKKGDIVMIYAYRGVDLMIAVMGVLKAGATFSVIDPAYPPARQNIYLSVAKPKGLIGLEKAGTLDQLVVDYISNELDVVSTIPQLKVQDDGTLVGGKLEGADNDCLNDYQKFKDQPAGVIVGPDSRPTLSFTSGSEGIPKGVLGRHYSLAYYFPWMAKRFRLSEKDKFTILSGIAHDPIQRDMFTPLFLGAQLLVPTADDIGTPGKLADWMAKYGATVTHLTLAMGQLLSAQATTAIPSLHAFFVGDILTKRDCLRLQSLAENVFIVNMLWSLSQTQRSVSYFEIKSRKADPTYLKNLKAVMPAGTGMHNVQLLVVNRNDRSQTCGVGEVGEIYVRAAGLAEGYRGLPDLNAAKFITNWYVNPDKWIEQDEANKKSSETSERTWSVKPRDRMYRSGDLGRYFSDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVRRDKNEEPTLISYIVPKDSPELKTFFADVDFPLKKSNDPIVKGLVAYRELIKDIKGYLKKKLASYAIPTIIVPLVKLPLNPNGKVDKPKLPFPDTAQLAAVAKLSVSSHDAQAAEEENLTKLEEQIRDLWLDVLPNRPATISKDDSFFDLGSHSILGTRIFTYEQKLNVEIPLVSFKGDQRRPRFPIGLSRYNYSRREQRCRRFLKAKTYTMRRSKELSKELSKSALLESYSSLKQLPSGSVNVFVTGATGFLGSFIVRDLLTARNKNLDIKVYAHVRASSKEAGLQRLRQTGITYGIWDENWAEKIEIVLGDLSKEKFGLDNSQWSDLTNSIDVLFTMVLCHWVYPYSQLRMLNVIGTINVFNMAGEVKLKFFSFVSSTSALDTDYFVNLSDELLAQGKNGISEADDLQGSAKGLGNGYGQSKWAAEYIIRRAGERGLKGCITRPGYVAGFSKTGASNTDDFLLRMLKGSAELGLYPDITNNVNMVPVDHVARVVTATALNPPSSEELTVAHVTGHPRILFNNFLGCLKAYGYEINPADYPVWTSALEKFVIEESKESALFPLLHFVLDNLPQDTKAPELDDSNAAKSLKQDSKYTGEDFSAGKGVDLDQTGVYISYLIKIGFLPKPTGTGEKKLPEVEISDESLKLISGGAGARGSAAK

LYS2

L-2-aminoadipate reductase large subunit

1385 amino acids

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Belongs to the ATP-dependent AMP-binding enzyme family.

151.953 kDa

MCAVLEPSMIRWLSEVDNIVVSSLPSDYIPSGPAGVKAESCEVELPGSFGVIDEEDSYIRLLSAFATLVCRMSGESDVAMYSKANRLLKLAVPPGVAFQQLRASVTEAVEGTLALPAVDFDELSALEREKKQLDYYPQYFKVGVVTAADKTKLDQFRYHKFELLLRQVTSSRFEMVYDSERFSPDRIGELGEQLVQFLTLVEAKDDADVYAISLVTSGASRVLPDPTTDLGWGQFRGAIHDIFQHHAETRPDRLCVVETGVGQVAARTFTYSAINCASNIVAHYLLARGIRRGDVVMIYSTRGVDLLVSVLGVLKSGAVFSVIDPAYPPARQNVYLGVAKPAGLIVIQAAGQLDEAVEAFIRDNLSLKARLPALALQTDGAILGGTLPDFHLDTLVPFASLKNTRTDVVVGPDSNPTLSFTSGSEGIPKGVLGRHFSLTYYFDWMAKRFGLSEDDKFTMLSGIAHDPIQRDMFTPIYLGAQLLVPQEDDIGTPGRLATWMATHGATVTHLTPAMGQVLTADATTPFPSLKRAFFVGDVLTKRDCARLQSLAENVAIVNMYGSTETQRAVSYFEVPSCSSNPSYLDNLKSIIPAGRGMHNVQLLIVNRHDRTKLCGIGEVGEIYVRAGGLSEGYRGLPEINKEKFIDNWFVDAGHWGGLDLSGDEPWRNYWLGVRDRLYRTGDLGRYLPNGDCECCGRADDQVKIRGFRIELGEIDTNISQYPLCRENITLLRKDQNGESTLISYLVPRSDQKALASFISAVPESIATESIAGSLIKYHKLINDIRGFLKKRLAGYAIPTLIMVMERLPLNPNGKIDKNKLQFPEPTELDRASEHFASETLGLSSFSPLEQEIRKIWLDLLPTRPAITSSDESFFDLGGTSILATRMAIVLRNRLNISLALSTIFRYPTVKELAKEISRVRGTISDDKSSNSGTTEYYADAKHVSEAELASKYESRLSLLPSGATSAPVYVFLTGVTGFLGCHILADLLNRSRKPYDITVYAHVRASDESSALQRIKSVCTAYGLWKNAYAPRIKVVLGNLAEKQFGLPKKAWHDLQEGIDVIIHNAALVHWVYPYSKLREANVLSTVNVLNLAAAGKAKYFTFVSSTSALDTKHYLELSNAAIESGGSGVPEDDDLMGGSLGLKGGYGQSKWAAEFIIKRAGERGLRGCILRPGYVTGSPSTGASNADDFLLRFLRGCVQLGKIPDIEGTVNMVPVDYVARLATAASFSSSGNTHMMVVNVNAKPRISFRDYLLALKEYGYQVTSVPYDEWSKALESSSDEENPLYPLLYLVLDDLPKKLRSPELDTTNAKFVLEEDFARTNIEPIIITSVSLEVVGSYISFLHKLGFLEEPAKGSRPLPNISLSDEQISLIAAVATARSSTAKP

LYS2

L-2-aminoadipate reductase large subunit

1374 amino acids

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Belongs to the ATP-dependent AMP-binding enzyme family.

152.537 kDa

MSWKERLDNPTLSVWPHDYLRPHAEPFVEQGTYSISIPQLSGDYATLLAAWTALLYRVTGDDDIVLYVRDNKVLRFTITPELTFTQLQNKINEQLAELANVEGTNFDALSESLQKESGLERPPQLFRIACVTEDLQLDRYTHSPLDIGLQLHESSSDVSIVFNKLLFSQDRITILADQLTLFLTSVLQNAKQVFTKVSLITDSSTSILPDPKANLDWCGFVGCIHDIFQDNAEKFPERTCVVETPPINSTKTRTFTYKDINEASNIVAHYLINTGIKRGDVVMIYSSRGVDLMVCVMGVLKAGATFSVIDPAYPPARQTIYLGVAKPKGLIVIRAAGQLDQLVEDYITKELDLVSRIPSIAIQDNGTVEGGSLPSESGDVLASYTELKSTRTGVVVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFSWMAKQFNLSENDKFTMLSGIAHDPIQRDMFTPLFLGAQLYVPTQDDIGTPGRLAEWMGKYGCTVTHLTPAMGQLLTAQAVTPFPKLHHAFFVGDILTKRDCLRLQTLAENCCIVNMYGTTETQRAVSYFEVTSRSQDPHFLKKLKDVMPAGRGMKNVQLLVVNRNDRTQVCGVGEIGEIYVRAGGLAEGYRGLPDLNKEKFVNNWFVEEGHWNYLDKDLEAPWKEFWQGPRDRLYRTGDLGRYLPNGDCECCGRADDQVKIRGFRIELGEIDTNISQHPLVRENITLVRNNLEGEKCLVTYMVPRFDKPELENFKIEVPSNISDDPVVCGLIGYSPFTKDLKAFLKKRLASYAIPSLIIVLPKLPLNPNGKVDKPKLQFPTVKQLELVAKNSSIDINDSEFNQQEREIRDLWLECLPTKPTSISPEDSFFDLGGHSILATKMIFTVKKQLNVELPLGTIFKYPTIKAFAAEVSRLKSTDKIEEETTALTADYASDAASLIDTLPKSYPAARALGSPSEMAGPTTVNIFVTGVTGFLGSFILSDILNRTVTGVNFKIFAHVRAADETSGLDRIRKAGTVYGTWKEEYANSLQVVIGDLSKKNFGLTDDKWSHLSETIDIIIHNGALVHWVYPYSKLRNANVVSTINIMNLASEGKPKLFNFVSSTSVLDTNHYFELSDKLQQSGKEGIPESDDLMGSSLGLTSGYGQSKWAAEHIIRAAGKRGLRGSIIRPGYVTGASYNGSSNTDDFLLRFLKSAVQLGKIPDINNTVNMVPVDQVARVVVAASINPPCGDDLCVVHVNAHPRIIFKDYLYELKNYGYDVEIENYEQWKKTLEEAVIERSEDNALFPLLHMVLGDLEDSTKAPELDDKNAITSLRADIEWTNEDRTKGMGATPEQIGIYISFLESVGFLPHPKHFGDKALPNIKISEQQKELVASGAGARSSSAA

lys2

Homoaconitase, mitochondrial

721 amino acids

Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.

Belongs to the aconitase/IPM isomerase family.

78.025 kDa

MDSGEMHHPYQAFSKVGKCEISQTNPSFSSGMRCLVRSADIQFKGICGLTRGFASFNKPPQTITEKIVQKFAQNIPENKYVRSGDYVTIKPKHCMSHDNSWPVALKFMGIGAKKVFDNRQIVCTLDHDVQNKSEANLRKYKNIESFAKGQGIDFYPAGRGIGHQIMVEQGYAMPGSMAVASDSHSNTYGGVGCLGTPIVRTDAAAIWATGQTWWQIPPIARVNLVGQLPKGLSGKDIIVSLCGAFNHDEVLNHAIEFYGEGLNSLSIESRLTIANMTTEWGALSGLFPTDEKLLAWYEDRLKFLGPNHPRVNRETLDAIKASPILADEGAFYAKHLILDLSTLSPAVSGPNSVKVYNSAATLEKKDILIKKAYLVSCTNGRLSDIHDAAETVKGKKVADGVEFYVGAASSEVEAAAQKNGDWQTLIDSGARTLPAGCGPCIGLGTGLLKDGEVGISATNRNFKGRMGSREALAYLASPAVVAASAIAGKIVAPEGFKNAVSLVSAVDITDKVNKQTASKSSTEAVDSETAIIDGFPSIVAGEIVFCDADNLNTDGIYPGRYTYRDDITKEEMAKVCMENYDSEFGKKTKKDDILVSGFNFGTGSSREQAATAILSRGIPLVVGGSFSDIFKRNSINNALLAIQLPDLVQKLRTAFANESKELTRRTGWHLKWDVRKSTVTVTTSDNKEMSWKIGELGNSVQSLFVRGGLEGWVKHEISKSN