Organism
Haemophilus phage HP1 (strain HP1c1)
Function
Signal-arrest-release (SAR) endolysin with lysozyme activity that degrades host peptidoglycans and participates with the pinholin and spanin proteins in the sequential events which lead to programmed host cell lysis releasing the mature viral particles. Once the pinholin has permeabilized the host cell membrane, the SAR-endolysin is released into the periplasm where it breaks down the peptidoglycan layer.
Similarity
Belongs to the glycosyl hydrolase 24 family.
Sequence
MSKKFGAMILCSAAAVAAAFFAQQKGLPTQQQNQVSPKAVSMIVNLEGCVRNPYKCPADVWTNGVGNTHNVDKTKILTIDEVATDLRRNIKEAENCINTYFNGEKMNQGQYDAMVSLAFNVGCGNIKTYYSKTQGKRVATTIYRAAQAENWILMCNRIEDFNKSGGRVLKGLQNRRAKEKALCLGE