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LINGO1

Gene
LINGO1
Protein
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Organism
Homo sapiens
Length
620 amino acids
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Mass
69.876 kDa
Sequence
MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI

Gene
LINGO1
Protein
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Organism
Macaca fascicularis
Length
614 amino acids
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Mass
69.188 kDa
Sequence
MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAMVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFIPNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI

Gene
Lingo1
Protein
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Organism
Mus musculus
Length
614 amino acids
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Mass
69.101 kDa
Sequence
MLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI

Gene
LINGO1
Protein
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Organism
Pongo abelii
Length
614 amino acids
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Mass
69.088 kDa
Sequence
MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPGGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI

Gene
LINGO1
Protein
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Organism
Gallus gallus
Length
613 amino acids
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity).
Mass
69.58 kDa
Sequence
MLAGEASMRSPILACWQPILLLMLGSILSGSATGCPPRCECSAQERAVLCHRKRFMVVPEGIPTETRQLDLGKNRIKTLNQDEFANYPHLEELELNENIISAIEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTSNCLYGLNLTSLSITHCNLTSIPYVSVRHLVYLRFLNLSYNPIVTIEGSMLHDLLRLQEIQLVGGQLTTVEPFAFRGLNYLRILNVSGNLLTTLEESAFHSVGNLETLILDNNPLACDCRLLWVFRRRWRLNFNKQQPTCSTPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKPQQIFVDEGHTVHFVCRADGDPPPAIMWLSPRKHLISTKTNGRLTVFPDGTLEVRYAQIQDNGTYLCIASNAGGNDTMLAHLHVRSYSPDWPHQPNKTFAFISNQPNESDANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI

Gene
lingo1
Protein
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Organism
Xenopus tropicalis
Length
606 amino acids
Function
May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Mass
68.704 kDa
Sequence
MILQLPSCLCPILLIVVGSILSGSASGCPQRCDCSPQDRSVLCHRKRYLDVPEGIPTDTRLLDLSKNRIKALNQDEFSAFPYLEELELNENIVSIIEPGAFNGLFNLRSLGLRSNRLKLIPLGVFTGLSNLTQLDISENKIVILLDDMFQDLYNLKSLEVGDNDLVYISHRAFRGLNSLEELTLEKCNLTSVPTEALSHLHGLITLKLRYLNINVIRDYSFKRLYRLKNLEIAHWPYLDTMTSNGLYGLNLTSLSITHSNLSSIPYVAIRHLVYLRFLNLSYNPITAVEGSMLYELLRLQEFHLVGGQLSVVEPYAFRGLNHLKVLNVSSNYLSTLEESSFHSVGNLETLILDKNPLACDCRLLWIFRRRWRLNFSRQQPSCSSPEYVQGKEFKDFPDVLQPNYFTCRRARIQDHSAQVVYVDEGHTVHFFCRADGDPPPTILWQSPRKTFITSKSNGRLTVFPDGTLEVRYAQVQDNGTYHCIASNAGGNDTSLAHLHVRSYSPNWPHKPNKTFAFMSNQPNESDVNSTRASVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGLSSADAPRKFNMKMI