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LIF2

Gene
LIF2
Protein
Heterogeneous nuclear ribonucleoprotein Q
Organism
Arabidopsis thaliana
Length
495 amino acids
Function
Transcriptional activator that binds DNA on GAGA-like motif and 5'-(C/G)ACGTG(G/T)C(A/G)-3' consensus motif in the promoters of target genes (PubMed:27495811). Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus (By similarity). Required during flower development and for cell fate determination (PubMed:21304947). Acts both as an antagonist and as a promoter of polycomb LHP1 gene regulation activity, depending of target genes, to regulate the transcription of stress-responsive and flowering genes (PubMed:21304947, PubMed:27495811). May regulate histone H3 trimethylation on lysine 27 (H3K27me3) (PubMed:21304947). Recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and acetylated at 'Lys-9' (H3K9ac), leading to epigenetic activation. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes (PubMed:27495811). May function as a suppressor of cell-autonomous immune responses involving glucosinolates, salicylic acid (SA) and jasmonic acid (JA) pathways toward pathogenic bacteria and fungi (PubMed:24914891).
Mass
55.136 kDa
Sequence
MSDARDNDDRVDFEEGSYSEMEDEVEEEQVEEYEEEEEEDDDDDDVGNQNAEEREVEDYGDTKGGDMEDVQEEIAEDDDNHIDIETADDDEKPPSPIDDEDREKYSHLLSLPPHGSEVFIGGLPRDVGEEDLRDLCEEIGEIFEVRLMKDRDSGDSKGYAFVAFKTKDVAQKAIEELHSKEFKGKTIRCSLSETKNRLFIGNIPKNWTEDEFRKVIEDVGPGVENIELIKDPTNTTRNRGFAFVLYYNNACADYSRQKMIDSNFKLEGNAPTVTWADPKSSPEHSAAAAQVKALYVKNIPENTSTEQLKELFQRHGEVTKIVTPPGKGGKRDFGFVHYAERSSALKAVKDTERYEVNGQPLEVVLAKPQAERKHDPSSYSYGAAPTPAPFVHPTFGGFAAAPYGAMGAGLGIAGSFSQPMIYGRGAMPTGMQMVPMLLPDGRVGYVLQQPGMPMAAAPPQRPRRNDRNNGSSGGSGRDNSHEHDGNRGGRRYRPY