LHX3

LIM/homeobox protein Lhx3

692 amino acids

May be involved in the determination of cell lineage of endoderm and notochord cells before gastrulation, and in specification of a distinct group of cells in neural tissue after gastrulation.

77.345 kDa

MNLMFHQARNNNSFMVAATSNQQHHKTALHVLEDKASGQVYDNQRIIASEQHSYGEYYIDEGKENSIPSESSARDYCGKELNKMASVTKESYVGGRLVDEDEDDYDDEGDREVYEDDITFDDDDDDENDDDDSDVKMNLRTNVNKLRFDSGFEYTLPTSSPENMTSFNPMSDSSHLFSDYSKHNSTILANGKSGTSYLTSTPRRIYDNTNMINIPEETKNIPTCYNGNNHVPSESIFDNPLSSGANRRMTSPGHKIQPSTCSDMLFTLLAKDNKIEAEIPKCTGCEHRIFDRFILKVQDKPWHSQGLKCNDCSAQLSEKCFSRGNLVFCKDDFFKRFGTKCTACGHGIPPTEVIRRAQDNVYHLEGFCCFLCHEKMGTGDQFYLLEDNRLVCKKDYEQAKSRDADIENGVKRPRTTITAKQLETLKSAYNQSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRIKRDTGRQRWGHFFSRNQLPSGPTSPISAPVTTGQKKRSNTKCGNRLIHCKDNQQNSQSHSSPLDGSPVFPIGSIGTGMQGEIGASFQSGCAVGIEGTSDLPSVMDPKNLPPYSETLMSYTEANPSHFVHGQNPSDVTYMNTLPVGGSHVPLTAVPQHNISAFSLPFHMEGNMVPDPSTQFMMATGHLGSQDTDLVSNSSGRSNFSDLSASPGSWLGELEHVQPF

Lhx3

LIM/homeobox protein Lhx3

400 amino acids

Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pou1f1/Pit-1.

44.01 kDa

MLLEAELDCHRERPGAPGASALCTFSRTPEIPMCAGCDQHILDRFILKALDRHWHSKCLKCSDCHVPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGSSKSDKDSIQEGQDSDAEVSFTDEPSMADMGPANGLYSSLGEPAPALGRPVGGLGSFTLDHGGLTGPEQYRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPDTNLSLVPSGPPGGPPPMRVLAGNGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF

lhx3

LIM/homeobox protein Lhx3

398 amino acids

44.226 kDa

MLLEHPGSSCQNAGNYTRYSSSQDIPVCAGCNQHIVDRFILKVLDRHWHSKCLKCSDCQSQLADKCFSRGDSVYCKDDFFKRFGTKCAACQQGIPPTQVVRRAQDFVYHLHCFACIVCKRQLATGDEYYLMEDSRLVCKADYETAKQREADSTAKRPRTTITAKQLETLKNAYNNSPKPARHVREQLSTETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGTSKSDKDSTQEDGMDSDAEVSFTDEPPMSDLGHSNGIYSSLSESSPALSRQGGNHPAFPLEHGAIIPSQEPYHDIQASSPYSLPQSPGPLQPLPRHQPLISSLVYPESGLPMAGQSGGQDMTPGVRMMAAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF

LHX3

LIM/homeobox protein Lhx3

397 amino acids

Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.

43.358 kDa

MLLETGLERDRARPGAAAVCTLGGTREIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGGSKSDKDSVQEGQDSDAEVSFPDEPSLAEMGPANGLYGSLGEPTQALGRPSGALGNFSLEHGGLAGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYPDTSLGLVPSGAPGGPPPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF

LHX3

LIM/homeobox protein Lhx3

395 amino acids

Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2.

43.805 kDa

MLLERVRAGSEKAAELCPFPRSPEIPLCAGCNQHIVDRFILKVLDRHWHSKCLKCSDCQTQLAEKCFSRGDGVYCKEDFFKRFGTKCAACQQGIPPTQVVRRAQDFVYHLHCFACIVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAESTAKRPRTTITAKQLETLKNAYNNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGTSKSDKDSIQEEGPDSDAEVSFTDEPSMSEMSHSNGIYSNLSEASPALGRQAGTNGGFSLDHSGIPAQDQYHDLRSNSPYGIPQSPASLQALPGHQPLISSLVYPDSGLGIMGQGGQGVPQSMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF

lhx3

LIM/homeobox protein Lhx3

395 amino acids

May be involved in the specification and maintenance of differentiation of distinct neuronal and neuroendocrine tissues. Early marker for the pituitary and pineal lineages, it may be involved in specifying these lineages.

44.031 kDa

MLLERVRTGTQKSSDMCGYTGSPEIPQCAGCNQHIVDRFILKVLDRHWHSKCLKCNDCQIQLAEKCFSRGDSVYCKDDFFKRFGTKCAACQQGIPPTQVVRRAQEFVYHLHCFACIVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAESTAKRPRTTITAKQLETLKNAYNNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGNSKSDKDSIQEEGPDSDAEVSFTDEPSMSEMNHSNGIYNSLNDSSPVLGRQAGSNGPFSLEHGGIPTQDQYHNLRSNSPYGIPQSPASLQSMPGHQSLLSNLAFPDTGLGIIGQGGQGVAPTMRVIGVNGPSSDLSTGSSGGYPDFPVSPASWLDEVDHTQF

LHX3

LIM/homeobox protein Lhx3

383 amino acids

Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity).

41.825 kDa

single

WEGRPQELGGKEIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSRGESLYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRARGGSKSDKDSVQEEGQDSDAEVSFTDEPSMAEMGPANGLYGGLGEPAPALGRPSGAPGSFPLEHGGLAGPEQYGELRPSSPYGVPSSPAALQSLPGPQPLLSSLVYPEAGLGLVPAGPPGGPPPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF