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LEU1

Gene
LEU1
Protein
3-isopropylmalate dehydratase
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
779 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
85.794 kDa
Sequence
MVYTPSKGPRTLYDKVFDAHVVHQDENGSFLLYIDRHLVHEVTSPQAFEGLENAGRKVRRVDCTLATVDHNIPTESRKNFKSLDTFIKQTDSRLQVKTLENNVKQFGVPYFGMSDARQGIVHTIGPEEGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPDETTFQYTKGRPLAPKGAEWEKAVAYWKTLKTDEGAKFDHEINIEAVDVIPTITWGTSPQDALPITGSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSCTNGRIEDLRSAAAVVRGQKLASNIKLAMVVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGMNPDILDAYERCASTSNRNFEGRQGALSRTHLMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSEDEKELESAAYDHAEPVQPEDAPQDIANDELKDIPVKSDDTPAKPSSSGMKPFLTLEGISAPLDKANVDTDAIIPKQFLKTIKRTGLKKGLFYEWRFRKDDQGKDQETDFVLNVEPWREAEILVVTGDNFGCGSSREHAPWALKDFGIKSIIAPSYGDIFYNNSFKNGLLPIRLDQQIIIDKLIPIANKGGKLCVDLPNQKILDSDGNVLVDHFEIEPFRKHCLVNGLDDIGITLQKEEYISRYEALRREKYSFLEGGSKLLKFDNVPKRKAVTTTFDKVHQDW
Protein
3-isopropylmalate dehydratase: LEU1

Gene
LEU1
Protein
3-isopropylmalate dehydratase
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
776 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
84.553 kDa
Sequence
MMTNGAKTLYDKVFEAHIVHQDESGSCLLYIDRHLVHEVTSPQAFEGLKTAGRPVRRTDCTLATVDHNIPTESRRHFRNTESFIKEADSRLQVQTLEQNVKDFHVPYLGMSDERQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTVIQSKSKNMRIHVEGSLSPGITSKDLILHIIGVIGTAGGTGCVIEFTGQAIQELTMEARMSMCNMAIEAGARAGMIQPDETTFEYLKGRPLAPTGAEWEKAVTYWKTLKTDEDAVFDISVTVKGADIRPTITWGTSPQDALPIDAAVPDPANVSDPIKRSGMEAALEYMGLEPNTLLKDIKIDKVFIGSCTNARIEDLRAAAAVVDGHRIAPTVKRAMVVPGSGLVKKQAEAEGLDKIFEAAGFEWREAGCSMCLGMNPDILGPKERCASTSNRNFEGRQGRLSRTHLMSPAMAAAAGIMGHFVDIREFEFKESSAPKVEVRHDTDSSTLEEANYGHAKEEPPSAELSDVAKQEKVNDIPVSNSSTQSPGSAPSADAGLQPFLQLQGIAAPLDKANVDTDAIIPKQFLKTIKRTGLKEGLFYDWRFAKHADGKVTGTDFVLNREPYRKATTLVVTGPNFGCGSSREHAPWALKDFGIMCIIAPSFGDIFYNNSFKNGLLPIRLPQDVIKEKLYPIASAGGELVIDLPAQQIADGEGHILVTQFDVEPSRKHCLVNGLDDIGLTLQKERFIADYEAMRRRDFSFLEGGSKLLPRISHSKPTSMPQAANDW
Protein
3-isopropylmalate dehydratase: LEU1

Gene
LEU1
Protein
3-isopropylmalate dehydratase
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
773 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
83.224 kDa
Sequence
MAPKTLYEKIFDSHLVHEEADGTCLIYIDRHLVHEVTSPQAFEGLRNANRKVRRTDCTLATVDHNIPTASRKSYRDTKSFVEQVDSRTQCMTLEENVKAFGLTFFGLSDNRQGIVHIIGPEQGFTLPGATIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKRAKNMLIQVDGELSQGVTSKDIILHIIGLIGTAGGTGHVIEYAGSTIRSLSMEARMSICNMSIEAGARAGLIAPDEITYEYIKGRPLAPKQGEAWDQALAYWKTLPSDEGAQYDTVIKIDAKDIPPTVTWGTSPQDVVAITGTVPDPKNASNEAEAKAWTRALEYMGLEAGTPMEKIKIDKVFIGSCTNARIEDLRAAARVLHGRKVADGLYCMLVPGSGLVKKQAEAEGLDKIFQAAGFDWREAGCSMCLGMNPDQLAPGERCASTSNRNFEGRQGAGGRTHLMSPAMAAACAVTGYLTDVRKVVGHSSAKVGSDAAKPAFEIEVSDAKSYLVDATPAPAPTNVAAAGAGALTDEDALRDVPASHISSSGGGMEKFTTLTGIAAPLERSNVDTDLIIPKQFLKTIKRTGLGSALFWPLRYDAKTGEPDPAFVLNQKPYDQSKILVVTGPNFGCGSSREHAAWSLLDFGIRAVIAESFGDIFRNNLTKNGQLPVVLSRAQIQRLTQDAKAGKQITVDLVDQLVITADGKEKFSFETPEFTRHCLINGLDDIALTLQRDAQIGAFERNRSTHTPWLDGFGYHANSNSSSLLDSAKPLVNNVTATDW
Protein
3-isopropylmalate dehydratase: LEU1

Gene
LEU1
Protein
3-isopropylmalate dehydratase
Organism
Candida maltosa
Length
770 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
85.317 kDa
Sequence
MSPKTLYDKVFEDHIVYEDESGSNLLYIDRHLVHEVTSPQAFEGLKNAGRTVRRTDCTLATVDHNIPTISRVNFKTLLTFIDQDDSRLQVQTLEQNVKDFDVTYFGMTDDRQGIVHVVGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTTIQANPKNMRITIDGELSEGITSKDLVLHVIGVIGTAGGTGCVIEFAGKAIEDLSMEARMSICNMAIEAGARAGMIKPDEKTFEYIKGRPLAPKGDEWEKALKYWKTLHTDDGAKLHYDIKIAASDIVPTITWGNSPQDALPITASVPDPANVSDPIKKSGMERALKYQGLTPNTPFVVIKMHKAFIGSCTNSRIEDLRAAAKVAKGHKKADNVKLVLVVPGSGLIKKQAEKEGLDKIFESAGFTWREAGCSMCLGMNPDILDPEERCASTSNRNFEGRQGARSRTHLMSPAMAAAAAIKGHFTDIREFDYVDNDEPSITIEHEVEDKELQDAVYEHEKEIIEGTPGTEAERSTTSLKMNQNSKKPNQMLIKMVPITVLPFLTGITAPLYKANVDTDAIIPKQFLKTIKRTGLKNGLFYESRFVKMPMVRCQTDFVLNVEPYRQAEILLVTGDNFGCGSSREHAPWALKDFGIKSIIAPSFGDIFYNNSFKNFLLPIRIPQDVIESKLVPVVKAGHKLTIDLPNQQIKDGETGDVLIEKFDVEEFRKHCLVNGLDDIGLTLQKEEYIQEYEAKRREKFSFLEGGSKLIKPIKGTKKSIYGNKAQEW
Protein
3-isopropylmalate dehydratase: LEU1

Gene
LEU1
Protein
3-isopropylmalate dehydratase
Organism
Rhizopus niveus
Length
750 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
81.309 kDa
Sequence
MARTLYDKVLEDHIIDRQEYGTCLIYIDRHLVHEVTSPQAFEGLRNAGRPVRRPDCTLATVDHNIPTSPRRNFKDIATFIKEGDSSTQCETLGENIEAFGLTYFGMEDSRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRIRVEGKPSAGVTSKDIALHVIGVIGTAGGTGCVIEFCGEANESLSMESRMSICNMSIEAGARAGMIAPDDITFEYLCNKPLASKGEEWDRAVAYWKTLKFDADAQYDITVDIKASDIAPTVTWGTSPQDVAPITGKTPDLDSIADPLRRLAVQRALDYIGIASNTPLEGVKIDKVFIGSCTNSRIEDLGPAAAIVKGKRVADWVDAMVVPGSALVKRQAERKGLDKIFQEAGFNWREAGCSMCLGMNPDQLKPGERCASTSNRNFKGRQGAGGRTHLLSPAMAAAAGIKGCLTDVRHMEVAGIALTGNESPRQEVVASKYDGSPEVFKSTQDTTPAVKPPQPASDSSSSGGMPAFTTLKGYAAPLDISNIDTDMIIPKQFLKTIKRTGLGSALFYSLRFDPQTGAENPAFVLKERTFRQARILVCTGPNFGCGSSREHAPWAFNDFGIRCILAPSFADIFFNNCFKNGMLPIVLPQAQLEAIAAEAQKGVEVEVDLVQQIVRNPGGEVSFDVEEFRKHCLVNGLDDIGLTMQKADKIAQFETKRTQTWPWLDGKGYKGKATKIEINGGQQKKAKLDW
Protein
3-isopropylmalate dehydratase: LEU1

Gene
leu1
Protein
3-isopropylmalate dehydratase
Organism
Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)
Length
744 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
80.834 kDa
Sequence
MSRTLYDKVWDDHVIDRHLVHEVTSPQAFEGLRNASRRVRRPDCTLATVDHNIPTTTRKKFKSITTFIDEADSRTQCETLETNVKEFELTYFGMEDSRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRVCVEGELTPGVTSKDVALHVIGLIGTAGGTRCVIEFCGSAIASLSMEARMSICNMSIEGGARAGMIAPDEITFEYLRGRPLAPEGAEWDKAVQYWKSLKSDPNAKYDIDVKIAASDIAPTITWGTSPQDVAPITANVPDPSSVSDPARKAAMERALEYIGLVPNTPLEEVKIDKAFIGSCTNSRIEDLRSAASIVKGKHIADWVYAMVVPGSGLVKRQAEREGLDKVFTDAGFDWREAGCSMCLGMNPDQLSPGERCASTSNRNFEGRQGAGGRTHLMSPAMAAAAAIRGYLTDVRKFSSTPMVPRSPPPKFQTIQPKVEDEAAHKQAADQADPVTDCPPAGSPVNKGAPVASAMPAFTTLKGVAAPLAISNVDTDMIIPKQFLKTIKRTGLGSALFYGLRYDPATGAEKPDFVLNQPAYRSSKILVCTGPNFGCGSSREHAPWAFNDFGIRCIIATSFADIFFNNCFKNGMLPIILSQEQVDTLAKYATQKAEIEVDLVHQKIRYPGGEIPFDXMIEEFRKHCLVNGLDDIGLTMQKDSAIEKFEAKRTSTWPWLDGKAYKGKATKVTAIGSASQPAKKLDW
Protein
3-isopropylmalate dehydratase: leu1

Gene
leu1
Protein
3-isopropylmalate dehydrogenase
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
371 amino acids
Function
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
Similarity
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Mass
39.733 kDa
Sequence
MCAKKIVVLPGDHIGPEIVASALEVLKVVEKKRPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTNPNCRPEQGLLKLRKSMGVWANLRPCNFASKSLVKYSPLKPEIVEGVDFCVVRELTGGCYFGERTEDNGSGYAMDTWPYSLEEVSRIARLAAWLAETSNPPAPVTLLDKANVLATSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRTLNGVVLTDNLFGDIISDEASVIPGSLGLLPSASLSGVVGKSEEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPKEAEAIEAAVRKVLDDTSIGGRGLYTRDLGGEASTADITKAVVEELEKIL
Protein
3-isopropylmalate dehydrogenase: leu1

Gene
LEU1
Protein
3-isopropylmalate dehydrogenase
Organism
Sordaria macrospora
Length
368 amino acids
Function
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
Similarity
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Mass
38.689 kDa
Sequence
MATHNIVVFGGDHCGPEVVVEAIKVLKSIETNSPSAGKFNLQNHLLGGASIDKHHDPLTDEALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSGYACDTEPYSRAEIERIARLAGFLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDLGGSATTSDMGNAVVAELEKILKA
Protein
3-isopropylmalate dehydrogenase: LEU1