Letm1

Mitochondrial proton/calcium exchanger protein

1013 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion.

Belongs to the LETM1 family.

113.58 kDa

MNALLRHKGRNLRTSHLAQNVYKRFLKSNCCACSSVNVTDEPAKEDELPRRSASTSVLELSRSLGTYRRFQPHANYGYDYSGYGFRHLHTSRTLLETSSSKIDATVKKLKNQQKEKVEEIMKEVANGQAAAVRASSAATATASSEKGQNASATAGSTSATASTTSLAKTADKSVAKPKKPLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQHKEHSSEEAKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEITLDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKARGMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLPDAVGAHTRHAIGESEGKVDNKTKIEIIKEEERKIREEREEEREETIAKRSAIKEEIPAPYVFAEKLSGSQDLLDHKEQSSVSETDKGISSTDVQLLSEALKTLSSDKQLVVEKETIKELKEELADYKEDVEELREVRQVVKEPVRESRAAKLLYNRVNKMISQLDNVLNDLEARQHQIKQAESSDYAASSPTVEPQQMVHIDELVATIRRMKEASDEERFKVVGDLLVKLDADKDGVISVNEITKAVQSIDREATNIDKKQLEEFTELLSKLASRRRHEEIVHIDDLMNNIKVLKETSDEARLKHIEAVLEKFDADKDGVVTVNDIRKVLESIGRDNIKLSDKAIEELISLLDKEQVLQAEQKIEKAIAKSMKEAEKLKSEVDKADKDLSKLVNDIHDSAKEIQDIANEMRDKEETVPDKAKELKAEPAFKDTAKTLKDNAKDLDDLAKDPKSDPKSPTKASTGSGPAGLSGGGPSSGSSGIATGSTTESALREAAERQMEKILPSTDIGLPPTIQTPSQPPTSKKATATASTLSTTITAKKLL

letm1

Mitochondrial proton/calcium exchanger protein

760 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity).

Belongs to the LETM1 family.

86.049 kDa

MAALLVRGCALRPSWATRSAPICARGEGMKGNFAESVCLGCTSLRLLNYRNACFRSCTAARPVYVASRKGDNEFLWTDISERRYYKYLSSPASWTALKMGPWDLSVRNLHLSRPLFDDSVVEKSLKSLKDKNKKLEEGGPVYSPVSEVETVKKSLGQKVIDEIKHYYHGFRLLWIDTKIAARMLRQILNGHAMSRRERRQFLRICADLFRLVPFLVFVIVPFMEFLLPVALKLFPNMLPSTFETFSKKEERLKKELRVKLELAKFLQDTIEEIALRNKAAKGDVTAEFATFFQKIRSTGERPSNEEIVRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMKLRSIKADDKLIADEGLDSLTVTELQAACRARGMRALGVTEDRLKEQLKQWLELHLDQEIPTSLLLLSRALYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAAVECEKVDNKTKLEATLQEEEAIRKENQEKEMERLADAAKESQQVAAKVDVQSAPEEAISGEMKTATADTAAEPAVAQMSASEQAEILKDTAPVLEGIKGEEITKEEIDILSDACTKLKEQKKLLTKEKEELSELKDDVQEYSEDLQEIKKELSKTGQEKVLQETKASKILTKRVNRMIGQMDKIISELENEEKVLDEHIEKGSVPPVGENLVSINELISIMRHIQKIPEQKLQRIAAALDENKDGKIDLDDVAKVVELIDKEDIDISTSQVAEIMELLQKEEKLAEKEKAKEKVEKEQAAEAQN

letm1

Mitochondrial proton/calcium exchanger protein

757 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity).

Belongs to the LETM1 family.

86.847 kDa

MASILLTRSRTPLLKTSRSLKNEFRKGKLSEGACFNCTALRLATNSPGVLGGIVWPHASSVQYLDNSSVLQRRLSRSPRLYCAILVPDPALPVHSRSTYHRTLAWPQNAPVRWVHTTGRLLDDSKVERSLRTLKDRNKKLEEGGPVYSPTVDAEPVRRTIRQRVIDEVKHYYHGFRLLWIDTTIAVRMLWRVLNGHILSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEEIALRNKASKGNVTEEFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEAEVLEVEGERRVDAEHALSSVDVAIHSETLRDTAPVLEGIKGEEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVEESKASQRLSKRVNRMIGRMDKIITELEKDKMVLDGQMDSETTPPIGENLISINELITVMKQIQNIPEHKLLSIADALDENKDGKIDIDDVIKVVELIDKEDIDISTNQVAEIMVMLQKEEKLMEKEKAKEKVEKEQAAKIQN

LETM1

Mitochondrial proton/calcium exchanger protein

752 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity).

Belongs to the LETM1 family.

85.849 kDa

MLLQSCGRRACRLPRALRRQAPLGNLGDRACLSCTSLRLANKMTVHFKYCTSVAPVYAYSKKDHYCCWTKGLERTYFTLMSSSGSWTPLAAMGVLGPKYLPVRWWHSSRSLQDDSIVEKSLKSLKDKNKKLEEGGPVYSPTEVEVVKKSIGQRIVDELKHYYHGFRLLWIDTKIAARMLWRILHGNTLSRRERRQFLRICADLFRLVPFLVFLVVPFMEFLLPVALKLFPNMLPSTFETKSKKEERLKKQLRVKLELAKFLQDTIEEMALKNKAAKGNVTKDFSTFFQKIRETGERPSNEEILRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRTIKADDKMIAEEGVDSLTVKELQAACRARGMRALGVTEERLREQLKQWLDLHLNQEIPTSLLILSRAMYLPDTLSPADQLKTTLQTLPESVAKEAQVKVAEVEGEKVDNKARLEATLQEEAAIRKENEEKEMERITEAAEKAKETLQVAAMKLESAVDLEPAVLQVKESQVAMDSKQELAKADMETLKDTAPVLEGIKGEEITKEEIDMLSDACNKLQEQKKSLTKEKEELEELKGDIQEYNEDLQEIKELSKAGQEEVVEESKASKRLTKRVNRMIGQIDKIINELETNQKTVDVKLDRGDSPPAGENLISIAELINAMKQIQKIPEEKLTRIAEALDENKDGKIDIDNVVKVVELIDKEDVDIGTSQVAEIMALLQKEEKLEEKEKAKEKQDKEAAEVKN

LETM1

Mitochondrial proton/calcium exchanger protein

739 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).

Belongs to the LETM1 family.

83.354 kDa

MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS

Letm1

Mitochondrial proton/calcium exchanger protein

739 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity).

Belongs to the LETM1 family.

83.06 kDa

MASILLRSCRGRGPARLASPRAASPRGSLRDRACLSCTRTVGLTSHESVLSRCCTPANPVYLYFKSEPLSCWTQRPECQGTVARAAWTPASARLVVTGPQYLPVRGWHSSSPLGEDSMIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVKKSLGQKILDELKHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLYHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKAAEVEGEQVDNKAKLEATLQEEAAIQQEHLEELKRAAETAKDIQPEVAEATVPGRPGAELQPKMVDVIPPSEILKDTAPVLEGLKGEEITKEEIDILSDACSKLKEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGDEKYIEESTASKRLSKRVQQMIGQIDGLITQLETTQQNGKLDPAAASSPTGESVISVDELISAMKQIKHIPEHKLISLTSALDENKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKVEEKEKAKEKAEKEAAEVKN

Letm1

Mitochondrial proton/calcium exchanger protein

738 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:27669901). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity).

Belongs to the LETM1 family.

82.989 kDa

MASILLRSCRGRGPARLAPPRAASPRGSLRDRACLSCTRTLGLTSRESVLSRCCTPAHPVYLCFKGEPLSCWTQRPECQGTAARTTWTPASARLVVTGPQYLPVRGWHSSSPLGEDSVIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVRKSLGQKVLDELRHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLHHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEKVDNKAKLEATLQEEAAIQQEHLEELKRASEAVKDIQPEVAEATLPGRPGPEPQPPVDDVILPSEVLTDTAPVLEGLKGEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYIEESAASKRLSKRVQQMIGQIDGLITQLETTQQDGKLGPSQSTPTGESVISITELISAMKQIKHIPEHKLISLTSALDDNKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKIEEKEKAKEKAEKEAAEVKN

LETM1

Mitochondrial proton/calcium exchanger protein

732 amino acids

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity).

Belongs to the LETM1 family.

81.818 kDa

MASILLRSCRGRGPARLPPPRSAAPRGPAGDLACLSGASAVGLMSYVPLPLGSCAPVRPVYLSLRADPLGCWTLRPKRACAVLAGPRLLPVRCWHSSRPLGDDSVVEKSLRSLKDKNKKLEEGGPVYSPPAQAAVRKPLGQRVLDELRHYYHGFRLLWIDTKIAARMLWRILHGHSLTRRERRQFLRICADLFRLVPFLFFVVVPFMEFLLPVAVKLFPNMLPSTFETQSSKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLELHLHQEIPTSLLILSRAMYLPETLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQRKSQAAVAQAAKEVEPEVVAEGAPGRPVAELQPEEPAVTLPSEVLKDSAPVLEGLKEEEITQEEIDVLSNACSKLKEQKKSLTKEKEELELLKGDVQDYSQDLQEIKKELSKTGEEMYVEESKASKRLTKRVQQMIGQMDSLLAQLEADQKAGRLGPAAEAAPAGETVISVSELINAMKQIKHIPESKLLSLASALDDNKDGKVDIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEAAEVQN