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LELG_03198

Gene
LELG_03198
Protein
Very-long-chain 3-oxoacyl-CoA reductase
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
350 amino acids
Function
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
38.57 kDa
Sequence
MSQIDQLLLSIASNKLAYYALLFSLLFGVFKLTTFTLRFASLIVDLFILPAVDFSKYGANRGNWAVVTGASDGIGKEYALQLAKRGLSIVLVSRTQSKLELLATEISSKYKVNTKIVAFDASKDDEENYLELEKAIYDLPITVLINNVGQSHSIPVPFLETEQKELRDIITINNTATLRITQVVAPAIVATVEKSQKKVRGLILTMGSFGGLLPTPYLATYSGSKAFLQAWSAALAGELNPKGVDVELVISYLVTSAMSKIRRSSLTIPNPKQFVASTLASVGRRNGAQERFATNTPYWAHAIMHFAIENTVGVYSKIANTLNFNMHKSIRTRALKKQEKRSRLAAEKIE