Protein
Leucine carboxyl methyltransferase 1 homolog
Organism
Arabidopsis thaliana
Function
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A (PP2A) catalytic subunits to form alpha-leucine ester residues (Probable) (PubMed:21558554). Involved in brassinosteroid (BR) signaling. Plays a negative role in BR signaling pathway. Functions as a positive regulator of BRI1 receptor-kinase degradation. Methylates PP2A, thus facilitating its association with activated BRI1. This leads to receptor dephosphorylation and degradation, and thus to the termination of BR signaling. May act upstream of ASK7/BIN2 (PubMed:21558554). Involved in methylation of PP2A during environemental stress responses (PubMed:28741704).
Similarity
Belongs to the methyltransferase superfamily. LCMT family.
Sequence
MAESRSNRAAVQATNDDASASKLSCVKKGYMKDDYVHLFVKRPVRRSPIINRGYFSRWAAFRKLMSQFLLSGTSSKKQILSLGAGFDTTYFQLLDEGNGPNLYVELDFKEVTSKKAAVIQNSSQLRDKLGANASISIDEGQVLSDHYKLLPVDLRDIPKLRDVISFADMDLSLPTFIIAECVLIYLDPDSSRAIVNWSSKTFSTAVFFLYEQIHPDDAFGHQMIRNLESRGCALLSIDASPTLLAKERLFLDNGWQRAVAWDMLKVYGSFVDTQEKRRIERLELFDEFEEWHMMQEHYCVTYAVNDAMGIFGDFGFTREGGGERMSSSASSP