LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Homo sapiens

Length

440 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

49.578 kDa

Sequence

MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Homo sapiens

Length

440 amino acids

Function

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

49.578 kDa

Sequence

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Papio anubis

Length

440 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

49.645 kDa

Sequence

MGPPGSPWQWVPLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYHKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRLAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVDVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLRGIQHLNMVFSNQTLEHINAILLGAYRQGPPASLTASPEPPPPE

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Oryctolagus cuniculus

Length

440 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

49.56 kDa

Sequence

MGPPGSPWQWVLLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPSVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGRVVISPGVQIRVPGFGKTYSVEYLDNNKLAGYMHTLVQNLVNNGYVRDETVRAAPYDWRLEPSQQEEYYGKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQSWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPLMSSIKLREEQRITTTSPWMFPSQGVWPEDHVFISTPSFNYTGRDFKRFFEDLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGIGLPTPHTYIYDHGFPYTDPVGVLYEDGDDTVATSSTDLCGLWRGRQPQPVHLLPLHETEHLNMVFSNQTLEHINAILLGAYRSGTPASPTASPGSPPPE

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

Lcat

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Rattus norvegicus

Length

440 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107, PubMed:14636062).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

49.727 kDa

Sequence

MGLPGSPWQWVLLLLGLLLPPATSFWLLNVLFPPHTTPKAELSNHTRPVILVPGCMGNRLEAKLDKPNVVNWLCYRKTEDFFTIWLDFNMFLPLGVDCWIDNTRVVYNRSSGHMSNAPGVQIRVPGFGKTYSVEYLDDNKLAGYLNTLVQNLVNNGYVRDETVRAAPYDWRLAPRQQDEYYQKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQPQSWKDHFIDGFISLGAPWGGSIKPMRILASGDNQGIPIMSNIKLREEQRITTTSPWMFPAHHVWPEDHVFISTPNFNYTGQDFERFFADLHFEEGWHMFLQSRDLLAGLPAPGVEVYCLYGVGMPTAHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQVQGRQSQGVHLLRMNGTDHLNMVFSNKTLEHINAILLGAYPHGTPKSPTASLGPPPTE

Protein

Phosphatidylcholine-sterol acyltransferase: Lcat

Gene

Lcat

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Mus musculus

Length

438 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:19065001). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels (PubMed:19065001). Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins (PubMed:19065001). Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:19065001). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

49.747 kDa

Sequence

MGLPGSPWQRVLLLLGLLLPPATPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNRLEAKLDKPDVVNWMCYRKTEDFFTIWLDFNLFLPLGVDCWIDNTRIVYNHSSGRVSNAPGVQIRVPGFGKTESVEYVDDNKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLAPHQQDEYYKKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQPQSWKDHFIDGFISLGAPWGGSIKAMRILASGDNQGIPILSNIKLKEEQRITTTSPWMLPAPHVWPEDHVFISTPNFNYTVQDFERFFTDLHFEEGWHMFLQSRDLLERLPAPGVEVYCLYGVGRPTPHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQPVHLLPMNETDHLNMVFSNKTLEHINAILLGAYRTPKSPAASPSPPPPE

Protein

Phosphatidylcholine-sterol acyltransferase: Lcat

Gene

Lcat

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Mus musculus

Length

438 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:19065001). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels (PubMed:19065001). Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins (PubMed:19065001). Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:19065001). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

49.747 kDa

Sequence

Protein

Phosphatidylcholine-sterol acyltransferase: Lcat

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Gallus gallus

Length

413 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

47.804 kDa

Fragment

single

Sequence

GRTGAGFTLLTLLLLLPQPTSQFWLFNVLFPPTTTPEAPPTNSTPPWCLVPGFLGNQLEAKLDKPDVVNWMCYRKTEDYFTIWLNLNTFLPVGVDCWIDNTRVVYNRTARKMTNAPGVHIRVPGFGKTYSVEYLDQSKLAGYLHTLVQNLVNNGYVRDQTVRAAPYDWRVGPQEQPEYFQNLKALIEEMHDEYQQRVFLIGHSMGNLNVLYFLLQQKQAWKDQYIGGFISLGAPWGGSVKPLRVLASGDNQGIPLMSNIKLREEQRMTTTSPWMFPTSLAWPEDHVFISTPSYNYTYRDYQRFFTDVNLEDGWYMWEDMKDLLKGLPPPGVDTYCLYGTGYPTVETYIYDEHFPYEDPVDMIYGDGDDTVNKRSSELCKRWRNQQKQKVHVQELRGIDHLNMVFSNLTLTLHQ

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Gallus gallus

Length

413 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

47.804 kDa

Fragment

single

Sequence

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Eliomys quercinus

Length

299 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

34.653 kDa

Fragment

single

Sequence

EDCFTIWLDLNIFLSLGVDCWIDNTRVIYNRSSGYMSNAPGVQIRVPGFGKTYSIEYLDDNKLAGYMHTLVQNLVNNAYVRDETVRAPPYDWRLEPRHQEEYYLKLAGLVEEMYATYGKPVFLIGHSLGFCHLLYFLLLQPQGIPIMSSIKLVEEQRITTTSPWMFPSHQVWPEDHVFISTPNFNYTFSDFQRFFADLHFEDGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPHTYMYDHGFPYTDPVGIIYEDGDDTVTTHSIELCSHWQGRQPQPVHLLPLRGTQHLNMVFSNKT

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Micromys minutus

Length

299 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

34.834 kDa

Fragment

single

Sequence

FFTIWLDINMFLPLGVDCWIDNTRVVYNRSSGRMSNAPGVQIRVPGFGKTYSVEYLDDNKLAGYLHTLVQNLVNNAYVRDETVRAAPYDWRLAPSQQDEYYQKLAELVEEMYDAYGKPVFLIGHRLGCLHVLHFLLHQSWKGIPIMSNIKLKEEQRITTTSPWMFPAHHVWPEDHVFISTPNFNYTGQDFKRFFADLHFEEGWYMFLQSRDLLEGLPAPGVEVYCLYGVGRPTRYTYIYDHNFPYKDPVAILYEDGDETVATRSTELCGQWQGRQSQPVYLLPMNGTDHLNMVFSNKTL

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Eliomys quercinus

Length

299 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

34.653 kDa

Fragment

single

Sequence

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Micromys minutus

Length

299 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

34.834 kDa

Fragment

single

Sequence

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Gerbilliscus gambianus

Length

293 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

33.822 kDa

Fragment

single

Sequence

TIWLDLNMFLSLGVDCWIDNTRVVYNRSSGRVSNAPGVEIRVPGFGKTYSVEYLDDNKLAEYMHTLVQNLVNNGYVRDETVRAAPYDWRLEPSQQDDYYQKLAGLIEEMYAAYGKPVFLIGHSLGCLHVLYFLLRQGIPIMSSIKLREEQRITTTSPWMFPDRDVWPEDHVFISTPEFNYTGQDFERFFSDLHFEEGWYMWLQSRDLLAGLPAPGVDVYCLYGVGLPTPHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQPVHLLPMNGTEHLNMVFSNKT

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Gerbilliscus gambianus

Length

293 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

33.822 kDa

Fragment

single

Sequence

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Myodes glareolus

Length

291 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

33.536 kDa

Fragment

single

Sequence

FFTIFLDLNMFLALGVNCWIDNTRVVYNRSSGRMSNAPCVQIRVPGFGKTYSVEYLDDNKLAGYMHTLVQNLVNNGYVRDETVLAAPYDWRLEPSQQEEYYQKLAGLVEEMHAAYGKPVFLIGHSVGCLHVLYFNQGIPIMSSIKLREEQRITTTSPWMFPARRVWPEDHVFISTPNFNYTGQDFKRFFEDLYFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPSTYIYDHSFPYKDPVAALYEDGDDTVATRSTELCGQVQGSQSQPVHWLPMNWTEQLNMLFSN

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Myodes glareolus

Length

291 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

33.536 kDa

Fragment

single

Sequence

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT

Gene

LCAT

Protein

Phosphatidylcholine-sterol acyltransferase

Organism

Sus scrofa

Length

188 amino acids

Function

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Mass

21.238 kDa

Fragment

multiple

Sequence

FWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNPDVVNWMCYRFTIWLDLNMFLPLGVDVPGFGKTYSVEYLDNSKAAPYDWRLEPSQQEEYYLKISLGAPWGGSDLHFEEGWYDLLAGLPAPGVEVYCLYGVGLPTPRXYIFDXGFPYXDPVQQQPVHLLPLPGTQHLNMVFSXQTLEXINAILLG

Protein

Phosphatidylcholine-sterol acyltransferase: LCAT