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LAMTOR4

Gene
LAMTOR4
Protein
Ragulator complex protein LAMTOR4
Organism
Bos taurus
Length
99 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).
Similarity
Belongs to the LAMTOR4 family.
Mass
10.686 kDa
Sequence
MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFRLHQGMSVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV

Gene
lamtor4
Protein
Ragulator complex protein LAMTOR4
Organism
Danio rerio
Length
99 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).
Similarity
Belongs to the LAMTOR4 family.
Mass
11.101 kDa
Sequence
MTTALTQGLERIPDQLGYLVISEDGVLASAGELENDEHTAGVIMQMVRTACRFRLHGTAEPPFKRMSVMFEDYVYAVTISGQKVFVVKRQNNQREPVIV

Gene
LAMTOR4
Protein
Ragulator complex protein LAMTOR4
Organism
Homo sapiens
Length
99 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Similarity
Belongs to the LAMTOR4 family.
Mass
10.741 kDa
Sequence
MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFRLHRGMNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV

Gene
Lamtor4
Protein
Ragulator complex protein LAMTOR4
Organism
Mus musculus
Length
99 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).
Similarity
Belongs to the LAMTOR4 family.
Mass
10.678 kDa
Sequence
MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFQLHHGTNIPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV

Gene
LAMTOR4
Protein
Ragulator complex protein LAMTOR4
Organism
Pongo abelii
Length
99 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).
Similarity
Belongs to the LAMTOR4 family.
Mass
10.741 kDa
Sequence
MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFRLHRGMNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV

Gene
lamtor4
Protein
Ragulator complex protein LAMTOR4
Organism
Xenopus tropicalis
Length
99 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).
Similarity
Belongs to the LAMTOR4 family.
Mass
10.966 kDa
Sequence
MTSTMTQGLERIPDQMGYLVMSEDGGVLASAGDLENDERLAGVIREMVAVACSFRDLGDQQPFKRMSIVFGEHTFLVTISGQKIYVVKRQNVVREPISV