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LAMTOR3

Gene
LAMTOR3
Protein
Ragulator complex protein LAMTOR3
Organism
Bos taurus
Length
124 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.65 kDa
Sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSNANTGLIVSLEKELAPLFEELRQVVEVS

Gene
LAMTOR3
Protein
Ragulator complex protein LAMTOR3
Organism
Gallus gallus
Length
124 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.68 kDa
Sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSNANTGLIVSLEKELTPLFEELRQVVEVS

Gene
lamtor3
Protein
Ragulator complex protein LAMTOR3
Organism
Danio rerio
Length
124 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.677 kDa
Sequence
MADNLRSYLYKQLPSVEGLHAIVVTDRDGAPVIKVANDNAPEYALRPAFLSTFALATDQGSKLGLSKNKSIICYYSTYQIVQFNRLPLVISFIASSNANTGLIFSLEKELVPLIEELRQVVEVA

Gene
LAMTOR3
Protein
Ragulator complex protein LAMTOR3
Organism
Homo sapiens
Length
124 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Similarity
Belongs to the LAMTOR3 family.
Mass
13.623 kDa
Sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQVVEVS

Gene
Lamtor3
Protein
Ragulator complex protein LAMTOR3
Organism
Mus musculus
Length
124 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Similarity
Belongs to the LAMTOR3 family.
Mass
13.553 kDa
Sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDSAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELIKVVEVS

Gene
lamtor3
Protein
Ragulator complex protein LAMTOR3
Organism
Pagrus major
Length
124 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.721 kDa
Sequence
MADDLKRYLYKQLQSVEGLHAIVVTDRDGVPVIKVANDNAPVHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQIVQFNRLPLVISFIASSNANTGLIMSLEKELAPLIEELRQVVEVT

Gene
LAMTOR3
Protein
Ragulator complex protein LAMTOR3
Organism
Pongo abelii
Length
124 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.639 kDa
Sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSTICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRRVVEVS

Gene
Lamtor3
Protein
Ragulator complex protein LAMTOR3
Organism
Rattus norvegicus
Length
124 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.58 kDa
Sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDSAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSNANTGLIVSLEKELAPLFEELIKVVEVS

Gene
LAMTOR3
Protein
Ragulator complex protein LAMTOR3
Organism
Taeniopygia guttata
Length
124 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.68 kDa
Sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSNANTGLIVSLEKELTPLFEELRQVVEVS

Gene
lamtor3
Protein
Ragulator complex protein LAMTOR3
Organism
Tetraodon nigroviridis
Length
124 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.681 kDa
Sequence
MADDLKRYLYKQLQSVEGLHAIVVTDRDGVPVVKVANDNAPVPALRPGFLSTFALATDQGSKLGLSKNKSIICYYNDYQIVQFNRLPLVISFIARSSANTGLIMSLENELAPLIEELKQVVEVT

Gene
lamtor3
Protein
Ragulator complex protein LAMTOR3
Organism
Xenopus tropicalis
Length
124 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the LAMTOR3 family.
Mass
13.761 kDa
Sequence
MAEELRRFLYKKLTSVDELHAIVVSDRDGVPVIKVANENAPEHALRPAFLSTFALATDQGSKLGLSKNKSIICYYSTYQVVQFNQLPLVVSFIASCNANTGLILSLEEELGSLFKELRQVVEIS