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LAMTOR1

Gene
lamtor1
Protein
Ragulator complex protein LAMTOR1
Organism
Xenopus laevis
Length
162 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. May play a role in late endosomes/lysosomes biogenesis and regulate both the recycling of receptors through endosomes and the MAPK signaling pathway. May be involved in cholesterol homeostasis. May also play a role in RHOA activation (By similarity).
Similarity
Belongs to the LAMTOR1 family.
Mass
17.827 kDa
Sequence
MGCCYSGETDTGKGDQGEREHLLPQNQSLPNNKQNGSEQNPTNNPSARTDEQAMLSRILAKTAQNIIDVSAVESQGMEQHECMDRARQYSTRLAKLSSNLMDWKNVPPLPSLTSQPHQILASDPVPFTDIQQVSKIAAYAFSALSQIRVDAKEDLVVQFGIP

Gene
lamtor1
Protein
Ragulator complex protein LAMTOR1
Organism
Xenopus tropicalis
Length
162 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. May play a role in late endosomes/lysosomes biogenesis and regulate both the recycling of receptors through endosomes and the MAPK signaling pathway. May be involved in cholesterol homeostasis. May also play a role in RHOA activation (By similarity).
Similarity
Belongs to the LAMTOR1 family.
Mass
17.772 kDa
Sequence
MGCCYSGETDTGKGDQGEREHLLPQSQSLPNKAPNESEQNSTNNPSARTDEQAMLSRILAKTAQNIIDVSAVESQGMEQHECMDRARQYSTRLAKLSSNLMDWKKVPPLPSLTSQPHQILASDPVPFADIQQVSKIAAYAFSALSQIRVDAKEDLVVQFGIP

Gene
LAMTOR1
Protein
Ragulator complex protein LAMTOR1
Organism
Bos taurus
Length
161 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity).
Similarity
Belongs to the LAMTOR1 family.
Mass
17.731 kDa
Sequence
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPVPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Gene
LAMTOR1
Protein
Ragulator complex protein LAMTOR1
Organism
Homo sapiens
Length
161 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Similarity
Belongs to the LAMTOR1 family.
Mass
17.745 kDa
Sequence
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Gene
Lamtor1
Protein
Ragulator complex protein LAMTOR1
Organism
Mus musculus
Length
161 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Similarity
Belongs to the LAMTOR1 family.
Mass
17.749 kDa
Sequence
MGCCYSSENEDSDQDREERKLLLDPSSTPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Gene
LAMTOR1
Protein
Ragulator complex protein LAMTOR1
Organism
Pongo abelii
Length
161 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity).
Similarity
Belongs to the LAMTOR1 family.
Mass
17.745 kDa
Sequence
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Gene
Lamtor1
Protein
Ragulator complex protein LAMTOR1
Organism
Rattus norvegicus
Length
161 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity).
Similarity
Belongs to the LAMTOR1 family.
Mass
17.721 kDa
Sequence
MGCCYSSENEDSDQDQEERKLLLDPSNTPTKALNGAEPSYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP