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LAF1

Gene
laf1
Protein
SWIRM domain-containing protein laf1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
297 amino acids
Function
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Mass
33.903 kDa
Sequence
MKSSQTLVYSIPRNVEKDTCAAAIKAYQYLISPPPSPIPNDKVASTVDVPKCSTIPESPKDSIVEPKPTATPVAQLHSKVYDLYRDSPKIWLRRERQWLQRHSPAYRFSTPAAKRPRRQPSSFLDVHASNTRKRGSPDTPDSGHSTPHSKGDVHPGMPQHNTRFKQSSREFSSNTQAIDVANTPYELLPDYSPDMSVLDKRSHPRPLRSEWKGPPLDLSNDENRHLLHPAELQLAATLRLPCLVYLDNKRRIFAEWHNRRTQGLSFRKTDAQRASRVDVNKASRLWKAFHDEGFFDD

Gene
LAF1
Protein
Transcription factor LAF1
Organism
Arabidopsis thaliana
Length
283 amino acids
Function
Transcription factor that promotes photomorphogenesis in the light by participating in the transmission of phytochrome A (phyA) signals to downstream responses (PubMed:11581165, PubMed:19482971). Probably acts by activating expression of light-induced genes. In darkness, its degradation prevents the activation of light-induced genes (PubMed:11581165).
Mass
32.433 kDa
Sequence
MAKTKYGERHRKGLWSPEEDEKLRSFILSYGHSCWTTVPIKAGLQRNGKSCRLRWINYLRPGLKRDMISAEEEETILTFHSSLGNKWSQIAKFLPGRTDNEIKNYWHSHLKKKWLKSQSLQDAKSISPPSSSSSSLVACGKRNPETLISNHVFSFQRLLENKSSSPSQESNGNNSHQCSSAPEIPRLFFSEWLSSSYPHTDYSSEFTDSKHSQAPNVEETLSAYEEMGDVDQFHYNEMMINNSNWTLNDIVFGSKCKKQEHHIYREASDCNSSAEFFSPSTTT