Protein
Secondary metabolism regulator LAE1
Organism
Gibberella moniliformis (strain M3125 / FGSC 7600)
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:22713715). Controls the expression of the bikaverin, fumonisins, fusaric acid, and fusarins gene clusters; as well as two clusters for which the corresponding secondary metabolite is unknown (PubMed:22713715).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Sequence
MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRTSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLADCDLIHMRMLLGSIQTDLWPQVYHNAFEHLAPGIGFLEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRRVRVTPQEHRQMLEATGFTDIRQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEEVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ