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LAE1

Gene
LAE1
Protein
Secondary metabolism regulator LAE1
Organism
Hypocrea atroviridis (strain ATCC 20476 / IMI 206040)
Length
349 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23826217). Controls the expression of the gamma-pentyl-pyrone gene clusters (PubMed:23826217). Required for the expression of cellulase (PubMed:23826217). Regulates asexual sporulation (conidiation) by environmental stimuli such as light and/or mechanical injury (PubMed:23826217). Required for oxidative stress tolerance (PubMed:23826217). Plays also a role in defense and parasitism on other fungi (PubMed:23826217).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
40.063 kDa
Sequence
MSSRNAPSGCVAPSPATAAPPSPTNLRLTVGQSGSESANEPGGEPEERILQDGFWEYGRFYGNWKKGKYNFPIDKEETSRLDILHKYFIVETEDRVTSVPLDKEGSPKIMDLGTGTGIWAFHVVEGYIPNAQIMAVDLNQIQPALIPRGVTTKQFDLEEPSWEPLLRDCDLIHLRLLYGSIRDDLWADTYRKIFEHLAPGGYVEHLEIDWTPQWDGEDHPTHSAIREWSQQFHRAMHRYRRSVKVSSEDTKRMMEAAGFTEFKETKIRCYLNPWSTDRHQREAARWFNLALGLGLEAMSLMPMIDMLHMKQEDVVDLCKRVKAETCVLRYHAYFTLHTWTAKKPASPPQ

Gene
LAE1
Protein
Secondary metabolism regulator LAE1
Organism
Hypocrea atroviridis
Length
349 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23826217). Controls the expression of the gamma-pentyl-pyrone gene clusters (PubMed:23826217). Required for the expression of cellulase (PubMed:23826217). Regulates asexual sporulation (conidiation) by environmental stimuli such as light and/or mechanical injury (PubMed:23826217). Required for oxidative stress tolerance (PubMed:23826217). Plays also a role in defense and parasitism on other fungi (PubMed:23826217).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
40.063 kDa
Sequence
MSSRNAPSGCVAPSPATAAPPSPTNLRLTVGQSGSESANEPGGEPEERILQDGFWEYGRFYGNWKKGKYNFPIDKEETSRLDILHKYFIVETEDRVTSVPLDKEGSPKIMDLGTGTGIWAFHVVEGYIPNAQIMAVDLNQIQPALIPRGVTTKQFDLEEPSWEPLLRDCDLIHLRLLYGSIRDDLWADTYRKIFEHLAPGGYVEHLEIDWTPQWDGEDHPTHSAIREWSQQFHRAMHRYRRSVKVSSEDTKRMMEAAGFTEFKETKIRCYLNPWSTDRHQREAARWFNLALGLGLEAMSLMPMIDMLHMKQEDVVDLCKRVKAETCVLRYHAYFTLHTWTAKKPASPPQ

Gene
LAE1
Protein
Secondary metabolism regulator LAE1
Organism
Hypocrea jecorina (strain QM6a)
Length
332 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23390613, PubMed:24909838). Required for the expression of VEL1 (PubMed:23390613). Regulates expression of the carbohydrate-active enzyme gene clusters, but does not act by directly modulating H3K4 or H3K9 methylation (PubMed:22554051). Required for conidiation (PubMed:22554051).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
38.405 kDa
Sequence
MSRNAPNGCVPPSQATAPPSPATSLRLTVGEPVSEPATESGERVLQDGFWEHGRFYGSWKPGKYLFPIDKEELNRLDVFHKYFLVARDEKVTSTPLRKDGRPKIMDLGTGTGIWAYNVVEEYAKDAEIMAVDLNQIQPALIPRGVTTKQFDIEEPSWDPLLRDCELIHMRLLYGSIRDDKWPHVYRKAFEHLAPGIGYIEQLEIDWMPRWENEDLPRHSALQEWAQLFQRAMHRYHRSVTVSGEATRRRMEAAGFTDFSETTIRCYVNPWSPDRHQRECARWFNLAFSLGLEAMSMMPMIDKLGMTKDDIVDLCSRAKKEMCILRYRAYCTL

Gene
LAE1
Protein
Secondary metabolism regulator LAE1
Organism
Botryotinia fuckeliana (strain B05.10)
Length
327 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:25625818). Controls the expression of the oxalic acid gene cluster (PubMed:25625818). Controls also the expression of proteases and carbohydrate-active enzymes (PubMed:25625818). Regulates sclerotia formation and plays a role in virulence (PubMed:25625818).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
37.6 kDa
Sequence
MVVAMAMANNGSLSPAPPAAFQEPPPDYTENGRLYHGLHKGKYMFPCDEDEKDRMDIFHKFFEVAMGGVLHSRNTTFTNNYDGPRILDLGTGTGIWAIDMADKYGSDMGTGEVLGLDLARIQPPTIPENLQFLQRDIESPWWGLEVESWDMVHIRMLSGSINSWPALYQKVRRYLKPQVGRFEQVEIDFTPRSDFGDIPADSALATWARNLFEATRRNFRPLAYNTEIRAMLQKEEFLDIQEEVIRIPLNPWPDDPQEKDVARWYNLALTQGLEAMTLGPMHRIYGWTKDDVTRLITEVRRDICNRKIRAYNNLHVWTARAPVKPPS

Gene
LAE1
Protein
Secondary metabolism regulator LAE1
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Length
316 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:20572938). Controls the expression of the gibberellins gene clusters, but does not affect bikaverin production (PubMed:20572938). Controls the expression of the fusaric acid gene cluster (PubMed:24389666). Acts as a virulence factors during infection, most likely through activation of gibberellins biosynthesis (PubMed:20572938).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
36.624 kDa
Sequence
MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRTSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLADCDLIHMRMLLGSIQTDLWPQVYHNAFEHLTPGIGFLEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRSVRVIPQEHRQMLEATGFTDVKQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEDVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ

Gene
LAE1
Protein
Secondary metabolism regulator LAE1
Organism
Gibberella moniliformis (strain M3125 / FGSC 7600)
Length
316 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:22713715). Controls the expression of the bikaverin, fumonisins, fusaric acid, and fusarins gene clusters; as well as two clusters for which the corresponding secondary metabolite is unknown (PubMed:22713715).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
36.707 kDa
Sequence
MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRTSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLADCDLIHMRMLLGSIQTDLWPQVYHNAFEHLAPGIGFLEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRRVRVTPQEHRQMLEATGFTDIRQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEEVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ

Gene
LAE1
Protein
Secondary metabolism regulator LAE1
Organism
Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O)
Length
307 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (By similarity). Controls the expression of the T-toxin gene cluster (PubMed:22383877). Promotes oxidative stress tolerance and acts as a virulence factors during infection (PubMed:22383877). Negatively regulate mycelial pigmentation and controls sexual development, as well as asexual development during vegetative growth (PubMed:22383877).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
36.056 kDa
Sequence
MTSNGLPVPAQNSNYMENGRWYHGFRRGLYMYPCDEPEKDRMDIYHQFFAVARRGQLHQAPVPSEPHLQPRILDVGCGTGIWAIDMADKYLNAEVLGLDLVNIQPEKIPPNLRFRVPRDYESPWTLGEDSWDLIHLRMACGSVESWPELYQKIYTHLKPGTGWIEHIEIDMEPRCDDYTLPPDSMLRKWYGWLADATQRAYRPIAYEHRTRQLLQAAGFIDIQETVIRVPYNTWPNDPHQKDIGRWYNLGLTEGLEALTFAPLTRVYHWDLNAHVRPIVEGVRRELCNRKIHAYNNIHIWTARRPQQ