Protein
Pentafunctional AROM polypeptide
Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)
Function
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
Similarity
In the C-terminal section; belongs to the shikimate dehydrogenase family.
Sequence
MANADVLKVSILGKESIHCGFHLIPYIAQTVLSNLPSSTYVLVTDTNVANFHLTAFEKEFEQRISSLPTSSTKPRFLSLVIPPGETSKSREGKANIEDFLLLHRCTRDSVILALGGGVIGDLVGFVAATFMRGVRFVQIPTTLLAMVDSSVGGKTAIDTPHGKNLIGAFWQPEYIFIDAAFLETLPSREFSNGMAEVVKTAAIWNEAEFISLESRSADIFAAIQTPSADYAGRSKQTRSIAQELLLSVIVGSISVKAHIVTIDERETGLRNLVNFGHTIGHAIEAVLTPTILHGECVSVGMILEGEISRQMGILSQVGVGRLNRCLKAYNLPVTLADPRIASLPAAKLLTVERLLDIMRIDKKNSGPEKKIVILSRIGATYEPKATVVPDSIIAKTLSEAAKVIPGVPRHHPVKMATPGSKSISNRALVLAALGKGTCRLKNLLHSDDTQVMMAALNELKGASFAWEDAGETLVVKGGEGSLSVPPKGKELYLGNAGTAARFLTTVCTLVQSSPQDNAEYTVITGNARMKQRPIGPLVTALQANGSKIDFLESEGCLPLAIAPQGLKGSQLQLAASVSSQYVSSILLCAPYAEEPITLELIGGQVISQPYIDMTVAMMKTFGVDVVRRKDPVTGKFLDVYEIPKAVYTNPPEYNIESDASSATYPLAIAAVTGTSCTIQNIGSASLQGDAKFAKEVLEKMGCQVSQTATETTVQGPPIGQLKAIEEVDMEVMTDAFLTATALAAVANGKTRIIGIANQRVKECNRIRAMIDELAKFGVETIELDDGLEIIGKPISDLKRGVSVHCYDDHRVAMAFSVLSTVVEGTIIEEKRCVEKTWPNWWDDLENKIGLTVQGVDLASVASEASASGTINHDSAASIILIGMRGTGKTFVGNLAAATLSWTCLDADAYFETKHEMGVREFVHQKGWQAFRDAEFEVLRELIAEKSQGHVISLGGGIVETPAARELLKEYAATKGPVVHIVRPIDEVIRYLNSEASRPAYDEAIVDVFRRREPWFGECCSHDFFNRFGDLPYSSPKATSREIARFFNHITGQRPNLAQNLTSGRRSYFLCLTYPDVTQSFPVIHELTQGVDAIELRVDLLRASKDYDSIEYSIPTLAYVSSQVAALRRVTSLPIVFTVRTQSQGGSFPDAAEKEAVELLKLALRLGVEYVDVEISLSEKKIKELVSLKGSSHMIASWHDWSGNMIWDGPVVKEKYDAAARFGDIIKIVGKANSIQDNFTLYNFVSKVNSTAGSKPFIAINMGLEGQMSRVLNSTLSPVSHPLLPSKAAPGQLSFKQIQNALHLLGLLPAQRFYLFGTPIAHSMSPTLHNTGFEILGLPHHYELLETKEVAEEIKIAIGDSAFGGASVTIPYKLDVIPLLDKLSPAAEAIGAVNTIIPRTTGSGRMLVGDNTDWLGIKACITEQLSSKPIHAALVIGAGGTARAAIYALSALNVGDIYLYNRTTSKAYELAHAFPHAPVHVLEQLGQWPNGAVPPCVIVSTVPASATTTEEETSGILLPSKLFDYRDGPAVVIDMAYKPAETPLLRLAKTAGDNWATVPGLEVLLEQGYVQFEMWTGRRCPKELVAKWLGRLTTDHKQFVFEEECES