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Kibra

Gene
Kibra
Protein
Protein kibra
Organism
Drosophila sechellia
Length
1295 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
144.908 kDa
Sequence
MPNLQQTASQSQHHLHPHHLRPQQQQQQQQHHHQQQRQQQQHTHHQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKSVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVQAIHEEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGDNLNEGARFAEMAKTTLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKTFSSESTFSISSGSSLGSLVHGQHKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALHAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCMELQEQIAAELMGLGPLNEPECSDDDDDDEEEELEDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSAAVSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRYLSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACDNKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDEDEFYNSPETAIAINTALVASSNRNKNLSEHLHRATSGAVPKIPAPVVTPAVTPAAAPAATPAATPAATPAATSAATPAATPVVSPAAQPDAKAADAPIPVASNDAEQQRFDYVVDRNYGVEV

Gene
kibra
Protein
Protein kibra
Organism
Drosophila melanogaster
Length
1288 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway.
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
144.35 kDa
Sequence
MPNLQQTASQSQHHLHPHHLRPQQQQQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDENEFYNSAETAIAINTALVASSNRNKNLSEHPHRATSGAVPKIPAPVVTPAATPAATPAATPAATSAATPAATPVVSPAAQPDAKPADAPIPVASNDAEQQRFDYVVDRNYGVEV

Gene
Kibra
Protein
Protein kibra
Organism
Drosophila willistoni
Length
1288 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
144.069 kDa
Sequence
MSNLPQTQAHHLQPHPQHPQHLLHHHQQQQQQQQQQQQQQHGHHNHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDRYTKPQSFEDCVGDELPVGWEEAYEPNIGRYYINHIAQSTQLEDPRQEWKSVQEQMLSDYLSAAQDQLENKREMYDVKQQRLLLAQEEYNHLNKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVRQLKQELNHITNDISHTERGMNTLYSVGEKINARENGCYDIAEVQAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELSRQQMNEENADLLNAASPFDRVCVASQTDLCGAGESLNGGARFAEMAKTKLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSLEETQVIQQTRQKLEDDLKEAYEANNTCIANRLRFHEEKQHLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYVDHFAVDSPIDVVDLQRRSQRFFQQQQQQQQHRLPPVHGHPVLQQQQSSEVSLSPRSSLSMETPPASPMKYNAGADQPQLPPAAASLAPPKEEPTYANALPAPPAYTAPPPAPIAAVRAPHAYDLDSTVLDCMILEAKLKKLNLNSPLNLAAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRRELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASSDNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPISLDKLLTKSLQVTVVSMTGQKEEIIGTVQISMAEFNPDDSTLKWYNVLSSKFMPSFESLDIPSTSAAAAAAAVAANNTNAMNSNSNNNREESSDESTITSSQTSTLTRNQAPPLELQAQIAEELPEHVRLNEQECSDDDDDDDDDDDEEEEDEQQLIGTEELTNSSGMLDTYLKIMKQQYADKETNTECAFPPEKSRAQSQLLDDRPVKRSQTFTPSAAVSKSRYNCRLNRSDSDSAMHFGVTPHTFHRGAAERRSLRFHTKAPKTATKLHHTHIPRTSLDLELDLQAQHSKLFFLNDQIAKLQNLKDVLQKGCESKDPLIAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEFILADGDAIEEEEEEDDNAAETAIAINTALVASSNRNKNLSEHHHRAACNSGAVPKRSATPTPITAATTADASASSAPATAAVAPTTAATVSDDKPDQQRFDYVVDRNYGVEV

Gene
Kibra
Protein
Protein kibra
Organism
Drosophila yakuba
Length
1288 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
144.094 kDa
Sequence
MPNLQQTASQSQSQHHLHPHHLRPHQQQHHQQQQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVQAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGDNLNGGARFAEMAKTKLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAAAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNSGNNREESSDESTITSSQTSTLTRNQAPCMELQEQIAAELLELGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSGMLDAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSAAVSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHTKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDEDEFYNSAETAIAINTALVASSNRNKNLSEHPHRATSGAVPKLPAPVATPAATPAATPVATPVATPVATPAATPVVSPAVQTDAKPAAAPIPVASSDAEQQRFDYVVDRNYGVEV

Gene
Kibra
Protein
Protein kibra
Organism
Drosophila erecta
Length
1283 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
143.67 kDa
Sequence
MPNLQQTASQSQHHLYPPHLRPHHHHQQQQHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMLDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVQAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGDNLNGGARFAEMAKTKLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLLPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAAAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPFFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPSSGNNREESSDESTITSSQTSTLTRNQAPCMELQEQITAELLELGPLNEPECSDDDDEDEEEELDDKQLVSDVGLMNSSGMLDAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSAAVSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHTKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDEDEFYNSPETAIAINTALVASSNRNKNLSEHPHRSTSGAVPKLPAPVATPAATPAATPAATPVATPAATPVVATAAQPEAKPAAAPIPVASNDAEQQRFDYVVDRNYGVEV

Gene
Kibra
Protein
Protein kibra
Organism
Drosophila virilis
Length
1276 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
143.315 kDa
Sequence
MSNQQQQQQQQQQPRQHPQPHPHHHHHHLHHHHQQQPGQHSEFPLPEGWDIARDFDGKTYYIDHINKKTTWLDPRDRYTKPQSFEDCVGDELPVGWEEAYDSNIGRYYINHIAQSTQLEDPRQEWKSVQEQMLSDYLSAAQDQLENKREMYDVKQQRLNLAQEEYNHLNKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVRQLKQELTHITNDISYTERGMNTLYSVGEKINARKNGCYDIAEVQAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELSRQQINEENAELMSAASPFDRVCVASQTDLCGAGEHLNGGARFAEMAKTKLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSAEEKQVIQQTRHKLEEDLKEAYEATNTCIANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVGESPIDVVDLQRRSQRLFQQHQRLPPVHPALQQQQQTQPLASSEVSLSPRSSLSMETPPASPMKYNAVADQPQAQAKLKEEPTYANALPALPTIPAPPAYAAPPAIPLALAAVRAHPYDLDSTVLDCMMLEAKLQKLNLGSPLNLNGPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLSALWTATTDNSQVYLRAALLPNSLTSIRTKALSDFQKPVFNDTFAVPISLDKLLTKSLQVTVVSMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDLPSTSAAAAAAAVAASNSNNNNSNTNNREESSDESTITSSQTSTLTRNQAPPLELQAQIAEELPEHVRHNEQQCSDDDDDDDEEEDEQQLVGTLGLTHSGCMLDAYLENMKQEYADKETNTDCAFPPEKLRSQSQLLDDRPVKRSQTFTPSAAVSKNRYNCRLNRSDSDSAMHFGVTPHTFHRGAVERRSLRFQPKATKSVTKLHHNHIPRTSLDLELDLQAQHSKLFFLNDQISKLQNLKEVLQKACDNKDPLIAAWAIENEEFQRLVARADPAKFPEERLLQKLLMKTTKEIHKLRKTKVPKGAPDLVSFKEKISFFTRKGMSVPELPIEFMHPDADAIEEEEEDDNDDEEDNVVETAIAINTALVASSNRNKNLSEHHHRSTDGALSKLAATLTPAINPAPVSAPIPVAVSVPVAAPLADEAKPEQQRYDYVVDRNYGVEV

Gene
Kibra
Protein
Protein kibra
Organism
Drosophila ananassae
Length
1271 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
142.669 kDa
Sequence
MPNQSQHHLQPHPHHLRPQQQQQQQQQQQQQQHHRQQQQQNHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGLYYINHLAQSTQLEDPRQEWKSVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELNHITNDISYTERGMNTLYSVGEKINARQNGCYDIAEVQAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELSRQQISEENSDLASPFDRVCVASQTDLCGSTGDNLNGGARFAEMAKTKLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIQQTRNKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQRLHPVHPGLQQQQQQQQQSSEVSLSPRSSLSMETPPASPMKYNPGADPTTPALKEEPTYANALPAPPAYTAPPPVPVSGVRARPYDLDSTVLDCMMLEAKLQKLNLGTPLNLAAAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKLEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPTFESLDLPSTSAAAAAVAVAASSSASNSIREESSDESTITSSQTSTLTRNQAPPMELQAQIAEEQPEQDGSDDDDDDDEEEDDNNKKIIREVAVGLMNSGCMLDTYLQNMKQEFADKETNTDCAFLPEKSRGQSQMMDDRPVKRSQTFTPSAAVSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHTKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLIAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGMSVPELPSEFTLPEANPIEEEEEEEEEDEDEFYNAAETAIAINTALVASNNRNKNLTDHLNRVSNYAAPKPPTIPAPPAASPAAPAGSNPPSATPSTTPATQATTTAVPVPADDNNPEQQRYDYVVDRTYGVEV

Gene
Kibra
Protein
Protein kibra
Organism
Drosophila mojavensis
Length
1264 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Similarity
Belongs to the WWC family. KIBRA subfamily.
Mass
142.031 kDa
Sequence
MSNQQQQQLPRQLPQPHPHHHHHHHQQQPGQHSEFPLPDGWDIARDFDGKTYYIDHINKKTTWLDPRDRYTKPQSFEDCVGDELPVGWEEAYDSNIGRYYINHIAQTTQLEDPRQEWKSVQEQMLSDYLSAAQDQLENKREMYDVKQQRLNLAQEEYNHLNKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVRQLKQELNHITNDISYTERGMNTLYSVGEKINARQNGCYDIAEVQAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELSRQQINEENAELLSATSPFDRVCVASQTDLCGAGEHLNGGARFAEMAKTKLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSAEEKLVIQQTRHKLEEDLKEAYEATNTCVANRLRFHEEKQLLLAKLQEALKSTNLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVGESPIDVVDLQRRSQRLFQQHQRLPPVHPAVQLQQQHQLQQQTQPQPASEVSLSPRSSLSIETPPASPMKYNAIADQPQAQAQAALKEEPTYANAMPAPPAYTAPPSVPMALAAVRTHPYDLDSTVLDCMMLEAKLQKLNLSSPLNLNGPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLSALWTATTDNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPISLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPDDSTLKWYNVLSSKFIPTFESLDLPSTSAAAAAAAVAASNNIINNNNNNNNNNIREESSDESTITSSQTSTLTRNQAPPLELQAQIAEELPEHVRLNEQQCSDDDDDDDEEEDEQQLVGTLGLTHSGCMLDAYLENMKQEYADKETNTDCAFPPEKLRSQTQLLDDRPVKRSQTFTPSAAVSKNRYNCRLNRSDSDSAMHFGVTPHTFHRGAVERRSLRFQPKATKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQISKLQNLKEVLQKACDNKDPLIAAWAIENEEFQRLVARADPTKCPEERLLQKLLMKTTKEIHKLRKTKVPKGCPDLVSFKEKMFFFTRKGMSVPELPNDFLLPDAQAIEEEEEDDDEDNVAETAIAINTALVASSNRNKNLSEHHHRSTGGAVSKLTATPTPAINPAPVATPVPATSNANEANGEQQRYDYVVDRNYGVEV