Protein
DNA topoisomerase 2
Organism
African swine fever virus (isolate Pig/Kenya/KEN-50/1950)
Function
Type II topoisomerase. Processively relaxes supercoiled DNA. Displays DNA-supercoiling activity only when associated with the viral histone-like protein.
Similarity
Belongs to the type II topoisomerase family.
Sequence
METFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCPALLKIFDELIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPIVKHEQASLIAKRDVYVPEVASCYFLAGTNINKAKDCIKGGTNGVGLKLAMVHSQWAILTTADGAQKYVQHINQRLDNIEPPTITPSREMFTRIELMPVYQELGYAQPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCSTSSVMALAKMYTLVTAPNSTIYTTTIKADAKPYSLHPLQVAAVVSPKFKKFEHVSIINGVNCVKGEHVTFLKKAINEMVVKKFQQTVKDKNRKTTLRDSCSNIFVVIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTRSIVDILLQSISKKDNHKQIDVDKYTRARNAGGKKAQDCMLLAAEGDSALSLLRAGLTLGKSNPSGPSFDFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVLGLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQLIVHGFVKRLLTPLIRVYEKGNTVPVEFYYEQEFDAWAKKQTSLANHTVKYYKGLAAHDTHEVKSMFKHFDKMVYTFTLDDSAKELFHIYFGGESELRKRELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLDGMTRARRKILAGGLKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSIIKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKTMFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQLEDILALVRAYIDKNNPKHELLHYAIDHKITVLPLRPSNYNFKGHLKRFGQYYYSYGTYVVSEQRNMITITELPLRVPTVAYIESIKKSSNRMAFIEEIVDYSSSETIEILVKLKPNSLSRIIEEFKETEEQNSIENFLRLRNCLHSHLNFVKPKGGIIEFNSYYEILYAWLPYRRDLYQKRLMRERAVLKLRIIMETAIVRYINESADLNLSHYEDEKEAGRILSEHGFPPLNQSLITSPEFATIEELNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQESPFPGASVWLEEIDAVEKAIIKGRNTQWKFH