KMO

Kynurenine 3-monooxygenase

486 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

55.81 kDa

MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR

Kmo

Kynurenine 3-monooxygenase

479 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

54.532 kDa

MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSYRGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLTAVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY

Kmo

Kynurenine 3-monooxygenase

478 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

54.353 kDa

MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH

kmo

Kynurenine 3-monooxygenase

474 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

54.247 kDa

METAFSHPPQSSSSKRKVIAVVGGGLVGSLNACFLAKRGFDVEVYESREDIRQAKVVKGRSINLALSHRGRQALKHVGMEDKIISKGIPMHARMIHNVNGKRSPIPYGKKGQYILSVDRANLNKELLTAAEAYPNTRLNFNHKLHDWSPKTGTMTFIGSDGQKTETQADLIVGCDGAFSAVRKQFLRQSRFNYSQTYIPHGYMELTMPPKDGDFAMEPNYLHIWPRNTFMMIALPNLDRTFTCTLFMPFEDFEKIRTGDELLRFFHKYFPDSVPLIGVEALKQDFFRLPAQAMVSVKCCPYHLFEKCVLMGDAAHAVVPFYGQGMNAGFEDCLVFDEIMDQFNENLVAVLQEYTRVRVPDDHAIADLAMYNYIEMRAHVNSKYFIFRKYLDNLLHFFMPKTIVPLYTMVTFTRTRYNDAVNRWHWQNKVITRGLWLCGFVSAAGGTYVLVKNSHKLPSISAEQLWTRILALKLF

kmo

Kynurenine 3-monooxygenase

473 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

54.261 kDa

MEIQGNRKKTVSVVGGGLVGSLNACFFAKKGFQVELYEAREDIRYARMVSGRSINLALSHRGLQALKAVGLDEKIAAMGIPMRARMIHSVKGRKSSIPYGKQHQYILSVDRANLNKELLSAAEKYSNVTMHFEHKLRDCNVDSGTMTFLNNMENIIEKKADLIVGCDGAFSVVRKQFMRKSRFNYSHVYIPHGYKELTIPPRKGEFAMEPNYLHIWPRNTFMMIALPNLDKSFTCTLFMPFEDFEKLTTGDQVLDFFKTYFPDSIELIGEKKLTEDFFLLPPQAMISVKCSSFCIDHKCVIMGDAAHAVVPFYGQGMNAGFEDCLVFSELMEQYQNNLRICLHEFSRLRVPDAHAISDLAMYNYKEMRAHVNSKWFIFRKQVDNILNAIMPTTFIPLYTMVTFSRIRYHEVILRWKWQKKIINVGLFTVGTTGSVGAAYLVIKYLPFNKYIEHVGNCLTHLKGNAYLSRLWAK

KMO

Kynurenine 3-monooxygenase

471 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

53.998 kDa

MDSSDIQRTSIAVIGGGLVGSLNACFLAKRNFQVDVYESREDIRMAEFARGRSINLALSYRGRQALKAIGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSISRENLNKDLLTAVEKYPNAKVHFGHQLLKCRPETGVITLLGPDKVPKDIACDLILGCDGAYSTVRTHLVKKPRFDYSQQYIPHGYMELTIPPQNGDFAMEPNYLHIWPRDTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSRDVLDFFQKYFPDSLHLIGKEALAQDFFRLPAQPMISVKCSSFHFNSHCVLMGDAAHALVPFFGQGMNAGFEDCLVFDELMDKFNNDFSMCLPEFSKFRIPDDHAISDLSMYNYIEMRSHVNSRWFIFQKNIERCLHTLMPSTFIPLYTMVTFSRIRYHEAMLRWQWQKKVINTALFFFGTLVALSTTYLLTGPTFRSSLGCLRRSWNSVTYFQNIGRISL

kmo

Kynurenine 3-monooxygenase

464 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.92 kDa

MSEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRGLHALRQVGLENEALKHAIPMRGRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTAAEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPGRVVFGTDGSASAIRQALEKRPDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFLPWQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQTLLLGDAAHAIVPFFGQGMNCGFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADMAVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYSLVSFSHVPYRLAYQMGALTDGIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG

kmo

Kynurenine 3-monooxygenase

461 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.712 kDa

MTATDNARQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLALAERGAHALRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEVIWSINRDRLNRILLDGAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERLEKRFHLLIGADGCNSAVRQAMASVVDLGEHLETQPHGYKELQITPEASAQFNLEPNALHIWPHGDYMCIALPNLDRSFTVTLFLHHQSPAAQPASPCFAQLVDGHAARRFFQRQFPDLSPMLDSLEQDFEHHPTGKLATLRLTTWHVGGQAVLLGDAAHPMVPFHGQGMNCALEDAVALAEHLQSAADNASALAAFTAQRQPDALAIQAMALENYVEMSSKVASPTYLLERELGQIMAQRQPTRFIPRYSMVTFSRLPYAQAMARGQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLPPLSHLC

kmo

Kynurenine 3-monooxygenase

460 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

52.261 kDa

MDILLNKPITIVGGGLAGSALALLLGQKGFPIQVIEKRPKQSENIRARSINLALSDRGVKTLTKTGYVDDILKIAIPMKGRMIHSLDSVQTFQAYSSDSNKHLYSVSRQLLNDRLREHTEKLENVKFIFSDACKSIDLKQCTIQTQDSNQTIEASTIIGCDGAFSAVRGSMVKLDRQDYSQSYLKHGYKELCIPSGPNQTFQIDKNSLHIWPRGSFMMIALPNIDGSFTCTLFFPFDGPLSFSSLDTREKVDQFFKDYFPDAYKLMPDLLDDYFENPTSSLVTVKTEPYHYQGKVVLVGDAAHAIVPFYGQGMNAAFEDVLELFNCFEDKSLYPSSTDKPFDNDHFNNIYKKYQENRKANSDAIAEMAVENFFEMRDHVGDALFLFKKKVEHLLEVKFPSRYISRYELISFSTQPYAYAQKIGLANQQILNELVKGNDDYNIEKIDLVLADQLIKKYLNK

kmo

Kynurenine 3-monooxygenase

456 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.945 kDa

MSAAASPRSLTLIGAGLAGCLLAILLSRRGWQITLYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMMRGRMIHPVSGEPQLQRYGRDDSEVIWSIHRAALNVTLLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQALVGSDGAGSALRAAMQRKAPVGEHIAFLDHSYKELEIPPRADGGFRIERNALHIWPRGRYMCIALPNDGGTFTVTLFLPNEGMPSFATTRSGDEALALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTRERWHLDGRAVLLGDAAHAMVPFHGQGMNCAFEDCVALAEQLDAHSDLSEAFAAFEAARRDDAAAIQQMALENYLEMRDRVGDAQFLLQRALEQQLQARWPTRFVPHYTMVTFLRTRYAIALARSEIQREILLEATHGHTDLSRIDWVALETVVHARLEPLEGAH

kmo

Kynurenine 3-monooxygenase

456 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.991 kDa

MSAAASPRSLTLIGAGLAGCLLAILLSRRGWQITLYERRGDPRIKGYESGRSINLALAERGRHALRQACAEDAVMAKAVMMRGRMIHPVSGEPQLQRYGRDDSEVIWSIHRAALNVTLLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQALVGSDGAGSALRAAMQRKAPVGEHIAFLDHSYKELEIPPRADGGFRIERNALHIWPRGRYMCIALPNDGGTFTVTLFLPNEGMPSFATTRSGDEALALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTRERWHLDGRAVLLGDAAHAMVPFHGQGMNCAFEDCVALAEQLDAHSDLSEAFAAFEAARRDDAAAIQQMALENYLEMRDRVGDAQFLLQRALEQQLQARWPTRFVPHYTMVTFLRTRYAIALARSEIQREILLEATHGHTDLSRIDWVALETVVHARLEPLEGAH

kmo

Kynurenine 3-monooxygenase

456 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.945 kDa

MSAAASPRSLTLIGAGLAGCLLAILLSRRGWQITLYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMMRGRMIHPVSGEPQLQRYGRDDSEVIWSIHRAALNVTLLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQALVGSDGAGSALRAAMQRKAPVGEHIAFLDHSYKELEIPPRADGGFRIERNALHIWPRGRYMCIALPNDGGTFTVTLFLPNEGMPSFATTRSGDEALALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTRERWHLDGRAVLLGDAAHAMVPFHGQGMNCAFEDCVALAEQLDAHSDLSEAFAAFEAARRDDAAAIQQMALENYLEMRDRVGDAQFLLQRALEQQLQARWPTRFVPHYTMVTFLRTRYAIALARSEIQREILLEATHGHTDLSRIDWVALETVVHARLEPLEGAH

kmo

Kynurenine 3-monooxygenase

455 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

51.074 kDa

MIAHASRSLSIIGAGLAGSLLAILLSRQGWRITLYERRGDPRVADYESGRSINLALAERGRNALRQAGVEDEVMARAVMMRGRMVHPREGEPQLQRYGRDDSEVIWSIHRSDLNTTLLELAEQAGATVHFHRRLHTVDFDAGYARFIDDRDDSPHDIRFDTLIGADGAGSALRAAMNRRAPLGEDIAFLDHSYKELEIPPADDGSFRIERNALHIWPRGHYMCIALPNHEGTFTVTLFLPNQGDPSFATINTGAQAEALFAREFADTLPLIPNLRADWEQHPPGLLGTLTLDRWHQQGRAVLIGDAAHAMVPFHGQGMNCAFEDCVALARHLMEADDLEGAFAAFEAERKPNARAIQQMALENYLEMRDRVADPAFLLQRELEQELQRRWPTRFVPHYTMVTFLHTPYAEALRRTELQRDMLVAATTGHDSLDNIDWAALEAQIHAQLPVLEGAH

kmo

Kynurenine 3-monooxygenase

455 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.858 kDa

MSPVSQRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMMRGRMVHPLVGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHIWPRGRYMCIALPNDGGTFTVTLFLPNAGEPSFATTRTGDEAFALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQREILVQATRGHSDLSRIDWSALEAVVHARLEPLDGAH

kmo

Kynurenine 3-monooxygenase

455 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.83 kDa

MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMMRGRMVHPIIGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVGFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHLWPRGRYMCIALPNDGGTFTVTLFLPNAGEPSFATTRTGDEALALFARDFPDALPLIPQLREHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQKLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQRQILVEATRGHRDLSRIDWAALEAVVHARLEPLDGAH

kmo

Kynurenine 3-monooxygenase

455 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.983 kDa

MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERGRHALRQAGAEELVMAKAVMMRGRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLPNAGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMALENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQREILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH

kmo

Kynurenine 3-monooxygenase

455 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

51.014 kDa

MNPVSPRSLTMIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERGRHALRQAGAEEVVMAKAVMMRGRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLPNAGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMALENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQREILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH

kmo

Kynurenine 3-monooxygenase

455 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.996 kDa

MNPVSPRSLTLIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERGRHALRQAGAEEVVMAKAVMMRGRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLPNAGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMALENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQREILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH

kmo

Kynurenine 3-monooxygenase

454 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

49.556 kDa

MNRRRERVVVVGAGLAGSLAALYLARQGHEVDIFERRPDPRSALAGPEGRSINLGLSARGMRALDGVGLLADVLKHSVPMRDRVVHSPDGGVRAQPYGVREHEILHSVLREELISLVVSAAEAEPGVRFHFDSLLTSLDRETGTVRVAPTAGGEASTVTADLVVGADGVFSTVRQQMQHGLRANYAQDFLPWGYKELTIPVGTDGQPRVRLEALHVWPGHEALMVAHPNRDGSLTCTLFMAHEGPVSFAALDTPAAVRDFFRRRFPDAEELMPDLVREITEHPVGHLVTVRTAPWRYADRVVLIGDAAHAVYPFYGQGMNSAFEDCVVLDECLTAHPDRAAALAAYEAARKPHTDVLADLSTANFEDLRDRVHRLGYSASAAADRLLARLLPQRWVPLYAMVAHTTIPYADALARANRQDRILRRAGAGLTLAVGLAATAAALRVGRRRRAARR

kmo

Kynurenine 3-monooxygenase

453 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

49.803 kDa

MNRRRERVVVVGAGLAGSLVALYLARQGHEVDVFERRPDPRSALGRPEGRSINLGLSARGMRALDGVGLLADVLKHSVPMRDRVVHSPDGGIRTQPYGVREHEILHSVLREELISLVVTAAEAEPGVRFHFDSLLASLDRETGTVDVAPTAGGETRTVTADLIVGADGAFSTIRQQMQHGLRANYAQEFLPWGYKELTIPVDADGQPRVRLEALHVWPGHEAMMIAHPNRDGSLTCTLFMAHEGPVSFAALDTPTAVRDFFRQRFPDAEELMPDLVREVTEHPVGHLVTVRSDPWRYADRVVLIGDAAHAVYPFYGQGMNSAFEDCVVLDECLTAHPDRATALAAYEAARKPHTDVLADLSTANFEDLRDRVHRLGYSASAAADRLLARLLPQHWVPLYGMVAHTTIPYADALARAKRQDRILRQAGAGLALVTVLAATAALRAGRRRRANRR

kmo

Kynurenine 3-monooxygenase

449 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

51.309 kDa

MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAIHEANGEVHYQPFGRHIDEYINAISRSDLNALLLNKAELCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSFAELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVTPVFYEQRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSIYDKKLAKII

kmo

Kynurenine 3-monooxygenase

449 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

51.334 kDa

MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAIHEANGEIHYQPFGRHIDEYINAISRSDLNALLLNKAKLCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSFAELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVNSVFYEHRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSLYDKKLAKII

kmo

Kynurenine 3-monooxygenase

449 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

50.783 kDa

MKEQITICGAGLVGSLLAVYLIERGFSVRVFEKRKDPRKNEADAGRSINLAISHRGIHALKDAQTGLEKEALKLAVPMYGRAIHDLHGHVSFQAYGEASQHINSIGRGALNKLLITTAENLGVHFLFEHTCTDYHAAGEQWLFSDITGNTVATQSKEIVIGADGAFSIVRSFLSKQQQPQPQIETLEYGYKELEIASAHTETITNNQALHIWPRERFMLIALPNEDGSYTATLFLPLKGEISFEALQSDQDIQLFFKKYFPDTENLFPDLTEQFYRHPTSKLFTIHSSNWFNAHTLLIGDAAHALVPFYGQGMNAGFEDCRILAEIIDGKSKTNWSEIFAEFYNQRKENADAISDLALQNFIEMRDHVADASFLLRKKIEKHLHQELEDAFIPQYTMVSFTDISYKEAMETGLLHQKILDEIMAIPDIEAAWPTEELKNKVITVTKKYI

kmo

Kynurenine 3-monooxygenase

447 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

51.302 kDa

MQKSQKIAIVGSGLVGSLLAIYLKKEGHTVHVYDRSPDIRTIQFSGRSINLAMSNRGWNALDGAGVGDKVRHIAIAMEKRAIHIGNQLNFQHYGLQGECIYSISRGVLNRKMIDLAEEAGAEFFFEQKIWDVNLTDATLQMGETERGEWTNVSYDMVFGADGAFSRIRHRMQRQSMFNYSQDFLNTGYKELHIPANPDGSYKLDKHSLHIWPRGKYMLIALPNLDGSFTCTLFMPFEGENSFASLDNRQKVEAFFAENLPDTVDVIPDLAEDFFKNPTSTLVTMKCFPWTYSDKVALIGDAAHAIVPFYGQGMNAGFEDITILYQMMQEYGNDWKTIFSEYEKSRKPDADAIAELSYRNFMEMSTKTANEKFLLQKKIERWFASKYPEKWIPLYDRVTFSTRPYSEALAIGDFQETIMQEILKIENIETNWETEEIEHKIIQLLNSK

kmo

Kynurenine 3-monooxygenase

447 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

51.75 kDa

MQKEKDVAIVGSGLVGSLLAIFLRKQGHKVTVFDRRPDVRNVQFSGRSINLAMSNRGWKALREAGIEDEIRELALPLDKRAMHVEGQSVYFQKYGEEGEAIYSISRGILNRKMIDLAESAGATFRFEEKIWDVDMKEARLYTGESEKSVWKEYQFDLIFGADGAFSRVRHKMQRQSRFNYSQHFIDVGYKELTILANEDGSHKMDNSSFHIWPRGNFMLIAMPNLDGTFTCTLFMPFDGETSFESIKTEDEADIFFEKYFPDIKDEISNLKKDFFKNPTSAMVTIKCFPWSYFDKITLVGDSAHAIVPFYGQGMNAGFEDISVLNEKMNLYGDDWEKVFEDYQTERKPNADAIAELSYRNFVEMSKKTADPKFLLRKKIEQKFAENHPDLWTPLYSRVTFSDKAYSDALKIGDYQREIMDEVMKIPGIEEKWESSEVEEKIISLIKK

kmo

Kynurenine 3-monooxygenase

446 amino acids

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

51.241 kDa

MQTSLKIAVVGSGLVGSLLAIYLKKAGHTVHVYDRSPDIRKINFSGRSINLAMSNRGWKALDGVGVGDAVREIAIPMDKRAIHLVDKLNFQNYGQEGESIYSISRGTLNRKMIDLAENAGAEFYFEQKIWDVTLSDATLHIGESERGEWEERKYDMVFGADGAFSRIRHRMQRQSMFNYSQEFLNMGYKELNIPANADRTHKLDKNSFHIWPRGEYMLIALPNLDGSFTCTLFMPFEGENSFESLTDRKMVEDFFEKNFPDSIEVIPELANDFFKNPTSTLVTMKCFPWTYEDKIALIGDACHAIVPFYGQGMNAGFEDITVLNEMIEKFGDDWKKIFTEYQISRKPNADAIAELSYRNFMEMSTKTADEKFLLQKKIEKVFSDKHPDKWIPLYSRVTFSDRPYAEALAIGDFQNGIMEEVLKLDNIENIWNTPEVENKILELLQK