Protein
4-aminobutyrate aminotransferase
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2 (By similarity). May be involved in an alternative, arginase-independent arginine degradation pathway via GABA (Probable).
Similarity
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Sequence
MSVAAKYYPNEPTEPKVVTSEIPGPESKAKVASLGEVFDSRPAYFVADYAKSSGNYIVDVDGNKFLDVYAQISSIALGYNNPALIEAAKSDKMIRALVDRPALGNFPGADLEDILKQLLKFAPKGQNKIWSGLSGADANELAFKAAFMYYRQLQRGGHGIDFSEEENSSVMENTSPGSPQLAVLSFKKAFHGRLFASGSSTCSKPIHKLDFPAFNWPHGEYPVYKYPLSENEEENKKEDDRCLAIVEDLIKSWPTPVAALIIEPIQSEGGDNHASKYFLQSLRDLTSKYNVVYIIDEVQTGVGATGKFWCHEWADIQPPVDLVTFSKKFQSAGYWFHDDRFIPNKAYRQFNTWCGDPARMIIAGAIGQEIVDNNLVDQCARVGDYLFEKLEKLQAKYPTRLINLRGKNRGTFIAFDLETSAERDQLLKLLKSNGCNVGGCAEKSVRLRPSLTFEEKHADIFVDALEKSIGQL